PMID- 31970322
OWN - NLM
STAT- MEDLINE
DCOM- 20200512
LR  - 20220412
IS  - 2532-1900 (Electronic)
IS  - 1128-2460 (Print)
IS  - 1128-2460 (Linking)
VI  - 38
IP  - 4
DP  - 2019 Dec
TI  - Fatigue in myotonic dystrophy type 1: a seven-year prospective study.
PG  - 239-244
AB  - OBJECTIVES: Cross-sectional studies reported fatigue in 50-90% of patients with 
      myotonic dystrophy type 1 (DM1). The aim of this research was to assess frequency 
      of fatigue in DM1 patients during a seven-year period. MATERIALS AND METHODS: 
      Study included 64 DM1 patients at baseline (50% males, age 42 +/- 12 years), and 38 
      after seven years. Following scales were used: Muscular Impairment Rating Scale 
      (MIRS), Fatigue Severity Scale (FSS, score equal to or greater than 36 indicates 
      significant fatigue), and Daytime Sleepiness Scale (DSS, score of more than six 
      is considered significant). RESULTS: At baseline, 54% of DM1 patients had fatigue 
      and 46% had excessive daytime sleepiness (EDS). Ten (32%) patients with fatigue 
      had no EDS. At the baseline, patients with fatigue were older, were more likely 
      to had adult-onset DM1, worse MIRS and DSS compared to the patients without 
      fatigue. After seven years, FSS score increased (34 +/- 15 vs 48 14, p < 0.01), 
      fatigue was found in 82% of patients, and EDS in 60%. Still eight (26%) patients 
      with fatigue had no EDS. Fatigue progression did not parallel MIRS increase. 
      CONCLUSIONS: Fatigue is a common symptom of DM1 and its progression during time 
      did not correlate with the progression of muscle weakness.
CI  - (c)2019 Gaetano Conte Academy - Mediterranean Society of Myology, Naples, Italy.
FAU - Peric, Stojan
AU  - Peric S
AD  - Neurology Clinic, Clinical Centre of Serbia, School of Medicine, University of 
      Belgrade, Belgrade, Serbia.
FAU - Bjelica, Bogdan
AU  - Bjelica B
AD  - Neurology Clinic, Clinical Centre of Serbia, School of Medicine, University of 
      Belgrade, Belgrade, Serbia.
FAU - Bozovic, Ivo
AU  - Bozovic I
AD  - Neurology Clinic, Clinical Centre of Serbia, School of Medicine, University of 
      Belgrade, Belgrade, Serbia.
FAU - Pesovic, Jovan
AU  - Pesovic J
AD  - Faculty of Biology, Centre for Human Molecular Genetics, University of Belgrade, 
      Belgrade, Serbia.
FAU - Paunic, Teodora
AU  - Paunic T
AD  - Neurology Clinic, Clinical Centre of Serbia, School of Medicine, University of 
      Belgrade, Belgrade, Serbia.
FAU - Banovic, Marija
AU  - Banovic M
AD  - Neurology Clinic, Clinical Centre of Serbia, School of Medicine, University of 
      Belgrade, Belgrade, Serbia.
FAU - Brkusanin, Milos
AU  - Brkusanin M
AD  - Faculty of Biology, Centre for Human Molecular Genetics, University of Belgrade, 
      Belgrade, Serbia.
FAU - Aleksic, Ksenija
AU  - Aleksic K
AD  - Neurology Clinic, Clinical Centre of Serbia, School of Medicine, University of 
      Belgrade, Belgrade, Serbia.
FAU - Basta, Ivana
AU  - Basta I
AD  - Neurology Clinic, Clinical Centre of Serbia, School of Medicine, University of 
      Belgrade, Belgrade, Serbia.
FAU - Pavicevic, Dusanka Savic
AU  - Pavicevic DS
AD  - Faculty of Biology, Centre for Human Molecular Genetics, University of Belgrade, 
      Belgrade, Serbia.
FAU - Stojanovic, Vidosava Rakocevic
AU  - Stojanovic VR
AD  - Neurology Clinic, Clinical Centre of Serbia, School of Medicine, University of 
      Belgrade, Belgrade, Serbia.
LA  - eng
PT  - Journal Article
DEP - 20191201
PL  - Italy
TA  - Acta Myol
JT  - Acta myologica : myopathies and cardiomyopathies : official journal of the 
      Mediterranean Society of Myology
JID - 9811169
SB  - IM
MH  - Adult
MH  - Disorders of Excessive Somnolence/*etiology
MH  - Fatigue/*etiology
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Myotonic Dystrophy/*complications
MH  - Prospective Studies
MH  - Severity of Illness Index
MH  - Sleepiness
PMC - PMC6955629
OTO - NOTNLM
OT  - fatigue
OT  - follow-up
OT  - myotonic dystrophy type 1
OT  - sleepiness
OT  - weakness
EDAT- 2020/01/24 06:00
MHDA- 2020/05/13 06:00
PMCR- 2019/12/01
CRDT- 2020/01/24 06:00
PHST- 2020/01/24 06:00 [entrez]
PHST- 2020/01/24 06:00 [pubmed]
PHST- 2020/05/13 06:00 [medline]
PHST- 2019/12/01 00:00 [pmc-release]
AID - am-2019-04-239 [pii]
PST - epublish
SO  - Acta Myol. 2019 Dec 1;38(4):239-244. eCollection 2019 Dec.