PMID- 31970676
OWN - NLM
STAT- MEDLINE
DCOM- 20210119
LR  - 20210119
IS  - 1993-0402 (Electronic)
IS  - 1672-0415 (Linking)
VI  - 26
IP  - 7
DP  - 2020 Jul
TI  - Baicalin Reduces Early Brain Injury after Subarachnoid Hemorrhage in Rats.
PG  - 510-518
LID - 10.1007/s11655-020-3183-7 [doi]
AB  - OBJECTIVE: To evaluate the effect of baicalin on subarachnoid hemorrhage (SAH) in 
      rats and explore the potential mechanisms. METHODS: Sprague-Dawley rats underwent 
      experimental SAH and received treatment with baicalin at 10 or 50 mg/kg after 2 
      and 12 h of SAH. Neurological scores, brain water content, Evans-blue 
      extravasation, and levels of glutathione peroxidase (GSH-Px), superoxide 
      dismutase (SOD), myeloperoxidase (MPO), and malondialdehyde (MDA) were measured 
      24 h after SAH. Expression of nuclear factor erythroid-related factor 2 (Nrf2), 
      NAD(P)H: quinone oxidoreductase 1 (NQO1), matrix metalloproteinase-9 (MMP-9), 
      aquaporin 4 (AQP4), occludin, and zonulaoccludens-1 (ZO-1) were detected in the 
      brain by Western blot. Heme oxygenase-1 (HO-1) was detected by quantitative 
      polymerase chain reaction, and tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta 
      (IL-1beta) were assessed by enzyme-linked immunosorbent assay. RESULTS: Baicalin 
      attenuated EBI 24 h after SAH in rats (P<0.05). Baicalin elevated neurological 
      scores, GSH-Px, SOD, and increased the expression of Nrf2, NQO1, HO-1, occludin, 
      and ZO-1 in SAH rats (P<0.05 or P<0.01). Baicalin reduced MPO, MDA, and the 
      expression of MMP-9, AQP4, TNF-alpha, and IL-1beta (P<0.05 or P<0.01). CONCLUSION: 
      Baicalin reduced SAH-induced EBI, partially via activation of the Nrf2/HO-1 
      pathway and inhibition of MMP-9 and AQP4.
FAU - Zhang, Hua-Bin
AU  - Zhang HB
AD  - Department of Neurosurgery, Fujian Medical University Union Hospital, 
      Neurosurgery Research Institute of Fujian Province, Fuzhou, 350001, China.
FAU - Tu, Xian-Kun
AU  - Tu XK
AD  - Department of Neurosurgery, Fujian Medical University Union Hospital, 
      Neurosurgery Research Institute of Fujian Province, Fuzhou, 350001, China. 
      unionnstu@hotmail.com.
FAU - Song, Shi-Wei
AU  - Song SW
AD  - Department of Neurosurgery, Fujian Medical University Union Hospital, 
      Neurosurgery Research Institute of Fujian Province, Fuzhou, 350001, China.
FAU - Liang, Ri-Sheng
AU  - Liang RS
AD  - Department of Neurosurgery, Fujian Medical University Union Hospital, 
      Neurosurgery Research Institute of Fujian Province, Fuzhou, 350001, China.
FAU - Shi, Song-Sheng
AU  - Shi SS
AD  - Department of Neurosurgery, Fujian Medical University Union Hospital, 
      Neurosurgery Research Institute of Fujian Province, Fuzhou, 350001, China.
LA  - eng
PT  - Journal Article
DEP - 20200123
PL  - China
TA  - Chin J Integr Med
JT  - Chinese journal of integrative medicine
JID - 101181180
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Flavonoids)
RN  - 347Q89U4M5 (baicalin)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents, Non-Steroidal/pharmacology
MH  - Brain Injuries/*drug therapy
MH  - Disease Models, Animal
MH  - Flavonoids/*pharmacology
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Subarachnoid Hemorrhage/*drug therapy
OTO - NOTNLM
OT  - Chinese medicine
OT  - aquaporin 4
OT  - baicalin
OT  - early brain injury
OT  - matrix metalloproteinase-9
OT  - subarachnoid hemorrhage
EDAT- 2020/01/24 06:00
MHDA- 2021/01/20 06:00
CRDT- 2020/01/24 06:00
PHST- 2018/10/31 00:00 [accepted]
PHST- 2020/01/24 06:00 [pubmed]
PHST- 2021/01/20 06:00 [medline]
PHST- 2020/01/24 06:00 [entrez]
AID - 10.1007/s11655-020-3183-7 [pii]
AID - 10.1007/s11655-020-3183-7 [doi]
PST - ppublish
SO  - Chin J Integr Med. 2020 Jul;26(7):510-518. doi: 10.1007/s11655-020-3183-7. Epub 
      2020 Jan 23.