PMID- 31970748
OWN - NLM
STAT- MEDLINE
DCOM- 20201013
LR  - 20201013
IS  - 1365-2249 (Electronic)
IS  - 0009-9104 (Print)
IS  - 0009-9104 (Linking)
VI  - 201
IP  - 1
DP  - 2020 Jul
TI  - Novel insights into dendritic cells in the pathogenesis of systemic sclerosis.
PG  - 25-33
LID - 10.1111/cei.13417 [doi]
AB  - Systemic sclerosis (SSc) is a severe autoimmune fibrotic disease characterized by 
      fibrosis, vasculopathy, and immune dysregulation. Dendritic cells (DCs) are the 
      most potent antigen-presenting cells, specialized in pathogen sensing, with high 
      capacity to shape the immune responses. The most recent technological advances 
      have allowed the discovery of new DC subsets with potential implications in 
      inflammatory conditions. Alterations of DC distribution in circulation and 
      affected tissue as well as impaired DC function have been described in SSc 
      patients, pointing towards a crucial role of these cells in SSc pathogenesis. In 
      particular, recent studies have shown the importance of plasmacytoid DCs either 
      by their high capacity to produce type I interferon or other inflammatory 
      mediators implicated in SSc pathology, such as chemokine C-X-C motif ligand 4 
      (CXCL4). In-vivo models of SSc have been vital to clarify the implications of DCs 
      in this disease, especially DCs depletion and specific gene knock-down studies. 
      This review provides these new insights into the contribution of the different 
      DCs subsets in the pathogenesis of SSc, as well as to the novel developments on 
      DCs in in-vivo models of SSc and the potential use of DCs and their mediators as 
      therapeutic targets.
CI  - (c) 2020 The Authors. Clinical & Experimental Immunology published by John Wiley & 
      Sons Ltd on behalf of British Society for Immunology.
FAU - Carvalheiro, T
AU  - Carvalheiro T
AUID- ORCID: 0000-0002-3187-2288
AD  - Center for Translational Immunology, University Medical Center Utrecht, Utrecht 
      University, Utrecht, the Netherlands.
AD  - Department of Rheumatology and Clinical Immunology, University Medical Center 
      Utrecht, Utrecht University, Utrecht, the Netherlands.
FAU - Zimmermann, M
AU  - Zimmermann M
AD  - Center for Translational Immunology, University Medical Center Utrecht, Utrecht 
      University, Utrecht, the Netherlands.
AD  - Department of Rheumatology and Clinical Immunology, University Medical Center 
      Utrecht, Utrecht University, Utrecht, the Netherlands.
FAU - Radstake, T R D J
AU  - Radstake TRDJ
AD  - Center for Translational Immunology, University Medical Center Utrecht, Utrecht 
      University, Utrecht, the Netherlands.
AD  - Department of Rheumatology and Clinical Immunology, University Medical Center 
      Utrecht, Utrecht University, Utrecht, the Netherlands.
FAU - Marut, W
AU  - Marut W
AUID- ORCID: 0000-0001-9039-2658
AD  - Center for Translational Immunology, University Medical Center Utrecht, Utrecht 
      University, Utrecht, the Netherlands.
AD  - Department of Rheumatology and Clinical Immunology, University Medical Center 
      Utrecht, Utrecht University, Utrecht, the Netherlands.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20200213
PL  - England
TA  - Clin Exp Immunol
JT  - Clinical and experimental immunology
JID - 0057202
RN  - 0 (PF4 protein, human)
RN  - 37270-94-3 (Platelet Factor 4)
SB  - IM
MH  - Animals
MH  - Dendritic Cells/*immunology/pathology
MH  - Disease Models, Animal
MH  - Humans
MH  - Platelet Factor 4/genetics/immunology
MH  - Scleroderma, Systemic/genetics/*immunology/pathology
PMC - PMC7290079
OTO - NOTNLM
OT  - conventional dendritic cells
OT  - dendritic cells
OT  - fibrosis
OT  - inflammation
OT  - plasmacytoid dendritic cells
OT  - systemic sclerosis
COIS- All authors have no conflicts of interest to declare.
EDAT- 2020/01/24 06:00
MHDA- 2020/10/21 06:00
PMCR- 2020/02/13
CRDT- 2020/01/24 06:00
PHST- 2020/01/16 00:00 [accepted]
PHST- 2020/01/24 06:00 [pubmed]
PHST- 2020/10/21 06:00 [medline]
PHST- 2020/01/24 06:00 [entrez]
PHST- 2020/02/13 00:00 [pmc-release]
AID - CEI13417 [pii]
AID - 10.1111/cei.13417 [doi]
PST - ppublish
SO  - Clin Exp Immunol. 2020 Jul;201(1):25-33. doi: 10.1111/cei.13417. Epub 2020 Feb 
      13.