PMID- 31971157
OWN - NLM
STAT- MEDLINE
DCOM- 20200512
LR  - 20210302
IS  - 1476-1645 (Electronic)
IS  - 0002-9637 (Print)
IS  - 0002-9637 (Linking)
VI  - 102
IP  - 3
DP  - 2020 Mar
TI  - Case Report: Subacute Sclerosing Panencephalitis in Pregnancy Mimicking Posterior 
      Reversible Encephalopathy Syndrome.
PG  - 634-636
LID - 10.4269/ajtmh.19-0901 [doi]
AB  - In posterior reversible encephalopathy syndrome, brain magnetic resonance imaging 
      (MRI) reveals bilateral occipital, parietal, and subcortical white matter 
      hyperintensities on T2/fluid-attenuated inversion recovery (FLAIR) sequences. 
      After treatment, imaging abnormalities are usually reversible. Eclampsia is the 
      most frequent cause of posterior reversible encephalopathy syndrome in pregnancy. 
      We report a 24-year-old woman, who presented to our clinic 4 weeks after normal 
      vaginal delivery with bilateral vision loss. Loss of vision was first noticed in 
      the 20th week of pregnancy. Even after delivery, her vision did not improve. In 
      the postpartum period, she started having periodic myoclonic jerks. 
      Electroencephalography demonstrated periodic generalized discharges. A brain MRI 
      performed in the 20th week of the antepartum period showed bilateral 
      parieto-occipital cortical white matter T2/FLAIR hyperintensities. A follow-up 
      brain MRI, 5 months later, revealed marked reversal of white matter signal 
      changes. Cerebrospinal fluid examination revealed raised anti-measles antibody 
      titer, confirming the diagnosis of subacute sclerosing panencephalitis. In 
      conclusion, in a patient with subacute sclerosing panencephalitis (SSPE) during 
      the postpartum period, cortical vision loss and parieto-occipital white matter 
      T2/FLAIR hyperintensities can simulate eclampsia. Inadvertent treatment with 
      magnesium sulfate is likely if the diagnosis is missed.
FAU - Sharma, Praveen Kumar
AU  - Sharma PK
AD  - Department of Neurology, King George Medical University (KGMU), Lucknow, India.
FAU - Garg, Ravindra Kumar
AU  - Garg RK
FAU - Singla, Shinu
AU  - Singla S
AD  - Department of Neurology, King George Medical University (KGMU), Lucknow, India.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Am J Trop Med Hyg
JT  - The American journal of tropical medicine and hygiene
JID - 0370507
RN  - 0 (Antibodies, Viral)
RN  - 0 (Interferon-alpha)
SB  - IM
MH  - Antibodies, Viral/blood
MH  - Blindness/*etiology/pathology
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Interferon-alpha/administration & dosage/therapeutic use
MH  - Measles virus/immunology
MH  - Posterior Leukoencephalopathy Syndrome/diagnosis
MH  - Postpartum Period
MH  - Pregnancy
MH  - Pregnancy Complications, Infectious/*pathology
MH  - Subacute Sclerosing Panencephalitis/diagnosis/drug therapy/*pathology
MH  - Treatment Failure
MH  - Young Adult
PMC - PMC7056428
COIS- Disclosure: R. K. G. receives regular honorarium for writing clinical summaries 
      for Med Link Neurology, Med Link Corporation San Diego USA.
EDAT- 2020/01/24 06:00
MHDA- 2020/05/19 06:00
PMCR- 2021/03/01
CRDT- 2020/01/24 06:00
PHST- 2020/01/24 06:00 [pubmed]
PHST- 2020/05/19 06:00 [medline]
PHST- 2020/01/24 06:00 [entrez]
PHST- 2021/03/01 00:00 [pmc-release]
AID - tpmd190901 [pii]
AID - 10.4269/ajtmh.19-0901 [doi]
PST - ppublish
SO  - Am J Trop Med Hyg. 2020 Mar;102(3):634-636. doi: 10.4269/ajtmh.19-0901.