PMID- 31971890
OWN - NLM
STAT- MEDLINE
DCOM- 20210909
LR  - 20210909
IS  - 1557-8585 (Electronic)
IS  - 1539-6851 (Linking)
VI  - 18
IP  - 4
DP  - 2020 Aug
TI  - Responsiveness of the Lymphedema Functioning, Disability, and Health 
      Questionnaire for Upper Limb Lymphedema in Patients with Breast Cancer-Related 
      Lymphedema.
PG  - 365-373
LID - 10.1089/lrb.2019.0073 [doi]
AB  - Background: The Lymphedema Functioning, Disability, and Health questionnaire for 
      Upper Limb Lymphedema (Lymph-ICF-UL) is a health-related quality-of-life 
      questionnaire for patients with breast cancer-related lymphedema. Previous 
      testing of this questionnaire showed very good psychometric properties; however, 
      responsiveness has not yet been established. The aim of this study was to 
      determine its internal and external responsiveness. Methods and Results: 
      Ninety-five patients treated with decongestive lymphatic therapy in a 
      longitudinal trial were recruited. Patients completed the Lymph-ICF-UL twice 
      within a time interval of 7 weeks ("intensive group" receiving intensive 
      treatment; n = 73) or 3 months ("stable group" receiving maintenance treatment; 
      n = 22), and once the Global Perceived Effect (GPE) questionnaire at the second 
      time point. The significance of change in scores and standardized response mean 
      (SRM) were determined for the total and domain scores. Correlations between 
      Lymph-ICF-UL and GPE were ascertained. In addition, the minimal clinical 
      important difference (MCID) was determined. The Lymph-ICF-UL total score changed 
      significantly in the intensive group (p < 0.001) and nonsignificantly for those 
      in the stable group (p = 0.25). The SRM represented moderate responsiveness 
      (0.65). Patients who reported a clinical improvement ( = responders) after 
      intensive treatment showed a significant decrease in total score (p < 0.001), 
      this was also the case for nonresponders (p < 0.001). Lymph-ICF-UL total and 
      domain scores showed nonsignificant weak correlations with the GPE (p > 0.05). 
      There was a significant difference in mean total score changes between responders 
      and nonresponders (p < 0.001). MCID for the total score was 9%. Conclusion: The 
      Lymph-ICF-UL is responsive to change after decongestive lymphatic therapy. No 
      correlations were found between Lymph-ICF-UL change scores and GPE. Future 
      studies should be conducted in a clinical setting, with more variability between 
      participants and their treatment responses.
FAU - De Vrieze, Tessa
AU  - De Vrieze T
AD  - Department of Rehabilitation Sciences, KU Leuven-University of Leuven, Leuven, 
      Belgium.
AD  - Department of Rehabilitation Sciences and Physiotherapy, MOVANT, University of 
      Antwerp, Antwerp, Belgium.
FAU - Gebruers, Nick
AU  - Gebruers N
AD  - Department of Rehabilitation Sciences and Physiotherapy, MOVANT, University of 
      Antwerp, Antwerp, Belgium.
AD  - Multidisciplinary Oedema Clinic, University of Antwerp and Antwerp University 
      Hospital, Antwerp, Belgium.
FAU - Nevelsteen, Ines
AU  - Nevelsteen I
AD  - Multidisciplinary Breast Centre, UZ Leuven-University Hospitals Leuven, Leuven, 
      Belgium.
FAU - Tjalma, Wiebren A A
AU  - Tjalma WAA
AD  - Multidisciplinary Oedema Clinic, University of Antwerp and Antwerp University 
      Hospital, Antwerp, Belgium.
AD  - Department of Molecular Imaging, Pathology, Radiotherapy, Oncology (MIPRO), 
      Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
AD  - Multidisciplinary Breast Clinic, Antwerp University Hospital, Antwerp, Belgium.
FAU - Thomis, Sarah
AU  - Thomis S
AD  - Department of Vascular Surgery and Centre for Lymphedema, UZ Leuven-University 
      Hospitals Leuven, Leuven, Belgium.
AD  - Department of Physical Medicine and Rehabilitation, Centre for Lymphedema, UZ 
      Leuven-University Hospitals Leuven, Leuven, Belgium.
FAU - De Groef, An
AU  - De Groef A
AD  - Department of Rehabilitation Sciences, KU Leuven-University of Leuven, Leuven, 
      Belgium.
FAU - Dams, Lore
AU  - Dams L
AD  - Department of Rehabilitation Sciences, KU Leuven-University of Leuven, Leuven, 
      Belgium.
AD  - Department of Rehabilitation Sciences and Physiotherapy, MOVANT, University of 
      Antwerp, Antwerp, Belgium.
FAU - Devoogdt, Nele
AU  - Devoogdt N
AD  - Department of Rehabilitation Sciences, KU Leuven-University of Leuven, Leuven, 
      Belgium.
AD  - Department of Vascular Surgery and Centre for Lymphedema, UZ Leuven-University 
      Hospitals Leuven, Leuven, Belgium.
AD  - Department of Physical Medicine and Rehabilitation, Centre for Lymphedema, UZ 
      Leuven-University Hospitals Leuven, Leuven, Belgium.
LA  - eng
SI  - ClinicalTrials.gov/NCT02609724
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200122
PL  - United States
TA  - Lymphat Res Biol
JT  - Lymphatic research and biology
JID - 101163587
SB  - IM
MH  - *Breast Cancer Lymphedema/diagnosis
MH  - *Breast Neoplasms/complications
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Quality of Life
MH  - Surveys and Questionnaires
MH  - Upper Extremity
OTO - NOTNLM
OT  - Lymph-ICF-UL questionnaire
OT  - breast neoplasms
OT  - lymphedema
OT  - psychometric properties
OT  - responsiveness
EDAT- 2020/01/24 06:00
MHDA- 2021/09/10 06:00
CRDT- 2020/01/24 06:00
PHST- 2020/01/24 06:00 [pubmed]
PHST- 2021/09/10 06:00 [medline]
PHST- 2020/01/24 06:00 [entrez]
AID - 10.1089/lrb.2019.0073 [doi]
PST - ppublish
SO  - Lymphat Res Biol. 2020 Aug;18(4):365-373. doi: 10.1089/lrb.2019.0073. Epub 2020 
      Jan 22.