PMID- 31972500
OWN - NLM
STAT- MEDLINE
DCOM- 20200928
LR  - 20200928
IS  - 1878-1667 (Electronic)
IS  - 0147-9571 (Linking)
VI  - 69
DP  - 2020 Apr
TI  - A comparison of commercial modified-live PRRSV-1 and PRRSV-2 vaccines against a 
      dual heterologous PRRSV-1 and PRRSV-2 challenge in late term pregnancy gilts.
PG  - 101423
LID - S0147-9571(20)30011-4 [pii]
LID - 10.1016/j.cimid.2020.101423 [doi]
AB  - This study compared the efficacy, in terms of reproductive performance, of a 
      porcine reproductive and respiratory syndrome virus (PRRSV)-1 or PRRSV-2 
      modified-live virus (MLV) vaccine against a dual heterologous PRRSV-1 and PRRSV-2 
      challenge. Gilts were administered either the PRRSV-1 or PRRSV-2 MLV vaccine at 
      21 days prior to breeding and were challenged intranasally with both PRRSV 
      species at day 93 of gestation. Vaccination of gilts with PRRSV-2 MLV vaccine 
      resulted in improved reproductive performance in sows (e.g. duration of 
      pregnancy) and piglet health and overall viability (e.g. increase of the number 
      of live-born and weaned pigs, and decrease of stillborn). Vaccination of gilts 
      with PRRSV-1 MLV vaccine was able to reduce only PRRSV-1 viremia in contrast, 
      PRRSV-2 MLV vaccine was able to reduce both PRRSV-1 and PRRSV-2 viremia. 
      Vaccination of gilts with PRRSV-2 MLV induced higher numbers of PRRSV-2 specific 
      interferon-gamma secreting cells (IFN-gamma-SC) compared to the PRRSV-1 MLV while there 
      was no difference in the number of PRRSV-1 specific IFN-gamma-SC between the two 
      vaccines. Taken together, the results presented here suggest that vaccination of 
      gilts with the PRRSV-2 MLV vaccine is more efficacious against dual heterologous 
      PRRSV-1 and PRRSV-2 challenge compared to the PRRSV-1 MLV vaccine.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Yang, Siyeon
AU  - Yang S
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea.
FAU - Oh, Taehwan
AU  - Oh T
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea.
FAU - Cho, Hyejean
AU  - Cho H
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea.
FAU - Chae, Chanhee
AU  - Chae C
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea. 
      Electronic address: swine@snu.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20200117
PL  - England
TA  - Comp Immunol Microbiol Infect Dis
JT  - Comparative immunology, microbiology and infectious diseases
JID - 7808924
RN  - 0 (Antibodies, Neutralizing)
RN  - 0 (Antibodies, Viral)
RN  - 0 (Antigens, Viral)
RN  - 0 (Vaccines, Attenuated)
RN  - 0 (Viral Proteins)
RN  - 0 (Viral Vaccines)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - Antibodies, Neutralizing/immunology
MH  - Antibodies, Viral/immunology
MH  - Antigens, Viral/immunology
MH  - Female
MH  - Interferon-gamma/biosynthesis
MH  - Open Reading Frames/immunology
MH  - Porcine Reproductive and Respiratory Syndrome/*prevention & control
MH  - Porcine respiratory and reproductive syndrome virus/classification/*immunology
MH  - Pregnancy
MH  - Pregnancy Complications, Infectious/*prevention & control
MH  - Seroconversion
MH  - Stillbirth
MH  - Swine
MH  - Vaccination/veterinary
MH  - Vaccines, Attenuated/administration & dosage/*immunology
MH  - Viral Proteins/immunology
MH  - Viral Vaccines/administration & dosage/*immunology
OTO - NOTNLM
OT  - Porcine reproductive and respiratory syndrome virus
OT  - Reproductive failure
OT  - Sow
OT  - Vaccine
COIS- Declaration of Competing Interest The authors declare no conflict of interest.
EDAT- 2020/01/24 06:00
MHDA- 2020/09/29 06:00
CRDT- 2020/01/24 06:00
PHST- 2019/11/25 00:00 [received]
PHST- 2020/01/08 00:00 [revised]
PHST- 2020/01/10 00:00 [accepted]
PHST- 2020/01/24 06:00 [pubmed]
PHST- 2020/09/29 06:00 [medline]
PHST- 2020/01/24 06:00 [entrez]
AID - S0147-9571(20)30011-4 [pii]
AID - 10.1016/j.cimid.2020.101423 [doi]
PST - ppublish
SO  - Comp Immunol Microbiol Infect Dis. 2020 Apr;69:101423. doi: 
      10.1016/j.cimid.2020.101423. Epub 2020 Jan 17.