PMID- 31974797
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210514
IS  - 1590-3478 (Electronic)
IS  - 1590-1874 (Linking)
VI  - 41
IP  - 7
DP  - 2020 Jul
TI  - Spectral domain OCT can differentiate the retinal morphological changes of 
      patients with Parkinson's disease in clinical middle stages.
PG  - 1909-1912
LID - 10.1007/s10072-020-04266-z [doi]
AB  - BACKGROUND: The retinal morphological change has been detected in Parkinson's 
      disease. However, the previous studies had a controversial conclusion. The aim of 
      this study was to observe the changes of retinal morphology in patients with 
      Parkinson's disease with different clinical stages based on Hoehn-Yahr stage by 
      spectral domain optical coherence tomography (SD-OCT). METHOD: Fifty-three PD 
      patients and forty-one healthy controls (HC) were enrolled. Subjects were 
      assessed for the retinal structure using SD-OCT and general ophthalmic 
      examinations. The PD group was divided into three subgroups by the Hoehn and Yahr 
      scale: H-Y I stage group, H-Y II stage group, and H-Y III stage group. RESULTS: 
      The mean deviation of visual field had a significant difference among the four 
      groups. The macular retinal thickness (MRT) and macular volume (MV) were 
      obviously decreased in PD patients. And the further statistical analysis showed 
      that the difference appeared between the H-Y III stage group and HC group. The 
      other subgroups had no differences compared with the HC group. CONCLUSION: SD-OCT 
      examination can detect the changes in retinal morphology in PD patients, and it 
      may not be found the difference until the patients are in the H-Y III stage (the 
      middle stage of PD).
FAU - Huang, Jiang
AU  - Huang J
AD  - Department of Ophthalmology, Second Affiliated Hospital of Soochow University, 
      Suzhou, Jiangsu, China.
FAU - Wang, Qingping
AU  - Wang Q
AD  - Department of Ophthalmology, Huashan Hospital North, Fudan University, Shanghai, 
      China.
FAU - Li, Kai
AU  - Li K
AD  - Department of Neurology, Second Affiliated Hospital of Soochow University, 
      Suzhou, Jiangsu, China.
FAU - Zhang, Qin
AU  - Zhang Q
AD  - Department of Neurology, Changsha Central Hospital, Changsha, China.
FAU - Xu, Guoxu
AU  - Xu G
AD  - Department of Ophthalmology, Second Affiliated Hospital of Soochow University, 
      Suzhou, Jiangsu, China.
FAU - Liu, Jing
AU  - Liu J
AD  - Department of Neurology, Second Affiliated Hospital of Soochow University, 
      Suzhou, Jiangsu, China.
FAU - Zhang, Ji
AU  - Zhang J
AD  - Department of Ophthalmology, Second Affiliated Hospital of Soochow University, 
      Suzhou, Jiangsu, China.
FAU - Niu, Tongtong
AU  - Niu T
AD  - Department of Ophthalmology, Second Affiliated Hospital of Soochow University, 
      Suzhou, Jiangsu, China.
FAU - Zhang, Qilin
AU  - Zhang Q
AD  - Department of Neurology, Second Affiliated Hospital of Soochow University, 
      Suzhou, Jiangsu, China.
FAU - Luo, Weifeng
AU  - Luo W
AUID- ORCID: 0000-0003-2626-1359
AD  - Department of Neurology, Second Affiliated Hospital of Soochow University, 
      Suzhou, Jiangsu, China. luoweifengsz@sohu.com.
LA  - eng
GR  - SYSD2016091/Suzhou Science and Technology Development Project/
GR  - No. 81671270/National Natural Science Foundation of China/
GR  - XKQ2015002/Project of Clinical Advantage Scientific Group of the Second 
      Affiliated Hospital of Soochow University/
GR  - BK20161220/Nature Science Foundation of Jiangsu Province/
PT  - Journal Article
DEP - 20200123
PL  - Italy
TA  - Neurol Sci
JT  - Neurological sciences : official journal of the Italian Neurological Society and 
      of the Italian Society of Clinical Neurophysiology
JID - 100959175
SB  - IM
MH  - Humans
MH  - *Nerve Fibers
MH  - *Parkinson Disease/diagnostic imaging
MH  - Retina/diagnostic imaging
MH  - Tomography, Optical Coherence
MH  - Visual Fields
OTO - NOTNLM
OT  - Hoehn and Yahr scale
OT  - Optical coherence tomography
OT  - Parkinson's disease
OT  - Retinal morphological changes
EDAT- 2020/01/25 06:00
MHDA- 2021/05/15 06:00
CRDT- 2020/01/25 06:00
PHST- 2019/09/19 00:00 [received]
PHST- 2020/01/18 00:00 [accepted]
PHST- 2020/01/25 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2020/01/25 06:00 [entrez]
AID - 10.1007/s10072-020-04266-z [pii]
AID - 10.1007/s10072-020-04266-z [doi]
PST - ppublish
SO  - Neurol Sci. 2020 Jul;41(7):1909-1912. doi: 10.1007/s10072-020-04266-z. Epub 2020 
      Jan 23.