PMID- 31974856
OWN - NLM
STAT- MEDLINE
DCOM- 20210802
LR  - 20210802
IS  - 1724-6059 (Electronic)
IS  - 1121-8428 (Linking)
VI  - 33
IP  - 4
DP  - 2020 Aug
TI  - Anti-beta-2-glycoprotein I domain 1 identifies antiphospholipid 
      antibodies-related injuries in patients with concomitant lupus nephritis.
PG  - 757-762
LID - 10.1007/s40620-019-00698-9 [doi]
AB  - BACKGROUND: In this study we aimed to evaluate the usefulness of domain profiling 
      of Beta-2-glycoprotein I(beta2GPI)-Domain-1 (D1) antibodies in relation to 
      antiphospholipid antibodies (aPL)-related nephropathy (aPL-N) in patients with 
      biopsy-proven lupus nephritis (LN). METHODS: Of 124 consecutive patients (96 
      women, mean age 45.5 +/- 12.3 years, mean disease duration 14.7 +/- 9.6 years) 
      fulfilling the 1982 criteria for systemic lupus erythematosus (SLE), we 
      identified 39 patients (mean age 39.84 +/- 8.6 years, mean disease duration 
      11.3 +/- 7.7 years) with the following characteristics: (a) biopsy-proven LN; (b) 
      no previous diagnosis of antiphospholipid syndrome (APS) according to the current 
      classification criteria. RESULTS: Patients with both LN and aPL-N had higher 
      median abeta2GPI-D1 antibody titres (220.1 CU, 25-75th IQ 29.1-334.2) as compared 
      those with LN alone (46.5 CU, 25-75th IQ 12.5-75.1) (p = 0.0087). Median 
      abeta2GPI-D1 antibody titres were higher in patients with acute thrombotic 
      microangiopathy (aTMA) (N = 7) (250.1 CU, 25-75th IQ 61.2-334.2) vs. with LN 
      alone (46.5 CU, 25-75th IQ 12.5-75.1 CU) (p = 0.0009). Having a Global 
      Antiphospholipid Syndrome Score > 10 confers an increased probability of having 
      acute features of aTMA (OR 6.25, 95%CI 1.2-31.8). As compared to other aPL, 
      abeta2GPI-D1 antibodies have the best diagnostic accuracy for aTMA as evaluated by 
      performances in Area Under the Curves in a ROC analysis. CONCLUSIONS: abeta2GPI-D1 
      antibodies detection might provide a second-line assay to be performed in abeta2GPI 
      positive patients with LN, allowing more accurate stratification of the renal 
      vascular involvement risk, thus potentially leading to a more tailored 
      management.
FAU - Sciascia, Savino
AU  - Sciascia S
AUID- ORCID: 0000-0003-1266-9441
AD  - Department of Clinical and Biological Sciences, Center of Research of 
      Immunopathology and Rare Diseases, Coordinating Center of Piemonte and Valle 
      d'Aosta Network for Rare Diseases, SCDU Nephrology and Dialysis, S. Giovanni 
      Bosco Hospital, Piazza del Donatore di Sangue 3, 10154, Turin, Italy. 
      savino.sciascia@unito.it.
FAU - Radin, Massimo
AU  - Radin M
AD  - Department of Clinical and Biological Sciences, Center of Research of 
      Immunopathology and Rare Diseases, Coordinating Center of Piemonte and Valle 
      d'Aosta Network for Rare Diseases, SCDU Nephrology and Dialysis, S. Giovanni 
      Bosco Hospital, Piazza del Donatore di Sangue 3, 10154, Turin, Italy.
AD  - Department of Clinical and Biological Sciences, School of Specialization of 
      Clinical Pathology, University of Turin, Turin, Italy.
FAU - Cecchi, Irene
AU  - Cecchi I
AD  - Department of Clinical and Biological Sciences, Center of Research of 
      Immunopathology and Rare Diseases, Coordinating Center of Piemonte and Valle 
      d'Aosta Network for Rare Diseases, SCDU Nephrology and Dialysis, S. Giovanni 
      Bosco Hospital, Piazza del Donatore di Sangue 3, 10154, Turin, Italy.
AD  - Department of Clinical and Biological Sciences, School of Specialization of 
      Clinical Pathology, University of Turin, Turin, Italy.
FAU - Fenoglio, Roberta
AU  - Fenoglio R
AD  - Department of Clinical and Biological Sciences, Center of Research of 
      Immunopathology and Rare Diseases, Coordinating Center of Piemonte and Valle 
      d'Aosta Network for Rare Diseases, SCDU Nephrology and Dialysis, S. Giovanni 
      Bosco Hospital, Piazza del Donatore di Sangue 3, 10154, Turin, Italy.
FAU - De Marchi, Andrea
AU  - De Marchi A
AD  - Pathology Division, Giovanni Bosco Hospital, Turin, Italy.
FAU - Besso, Luca
AU  - Besso L
AD  - Nephrology and Dialysis, Santa Croce Hospital, Cuneo, Italy.
FAU - Baldovino, Simone
AU  - Baldovino S
AD  - Department of Clinical and Biological Sciences, Center of Research of 
      Immunopathology and Rare Diseases, Coordinating Center of Piemonte and Valle 
      d'Aosta Network for Rare Diseases, SCDU Nephrology and Dialysis, S. Giovanni 
      Bosco Hospital, Piazza del Donatore di Sangue 3, 10154, Turin, Italy.
FAU - Rossi, Daniela
AU  - Rossi D
AD  - Department of Clinical and Biological Sciences, Center of Research of 
      Immunopathology and Rare Diseases, Coordinating Center of Piemonte and Valle 
      d'Aosta Network for Rare Diseases, SCDU Nephrology and Dialysis, S. Giovanni 
      Bosco Hospital, Piazza del Donatore di Sangue 3, 10154, Turin, Italy.
FAU - Miraglia, Paolo
AU  - Miraglia P
AD  - Department of Clinical and Biological Sciences, Center of Research of 
      Immunopathology and Rare Diseases, Coordinating Center of Piemonte and Valle 
      d'Aosta Network for Rare Diseases, SCDU Nephrology and Dialysis, S. Giovanni 
      Bosco Hospital, Piazza del Donatore di Sangue 3, 10154, Turin, Italy.
FAU - Rubini, Elena
AU  - Rubini E
AD  - Department of Clinical and Biological Sciences, Center of Research of 
      Immunopathology and Rare Diseases, Coordinating Center of Piemonte and Valle 
      d'Aosta Network for Rare Diseases, SCDU Nephrology and Dialysis, S. Giovanni 
      Bosco Hospital, Piazza del Donatore di Sangue 3, 10154, Turin, Italy.
AD  - Department of Clinical and Biological Sciences, School of Specialization of 
      Clinical Pathology, University of Turin, Turin, Italy.
FAU - Roccatello, Dario
AU  - Roccatello D
AD  - Department of Clinical and Biological Sciences, Center of Research of 
      Immunopathology and Rare Diseases, Coordinating Center of Piemonte and Valle 
      d'Aosta Network for Rare Diseases, SCDU Nephrology and Dialysis, S. Giovanni 
      Bosco Hospital, Piazza del Donatore di Sangue 3, 10154, Turin, Italy.
LA  - eng
PT  - Journal Article
DEP - 20200123
PL  - Italy
TA  - J Nephrol
JT  - Journal of nephrology
JID - 9012268
RN  - 0 (Antibodies, Antiphospholipid)
RN  - 0 (beta 2-Glycoprotein I)
SB  - IM
MH  - Adult
MH  - *Antibodies, Antiphospholipid/immunology
MH  - *Antiphospholipid Syndrome/immunology
MH  - Female
MH  - Humans
MH  - *Lupus Erythematosus, Systemic/immunology
MH  - *Lupus Nephritis/immunology
MH  - Male
MH  - *beta 2-Glycoprotein I/immunology
OTO - NOTNLM
OT  - APS
OT  - Antiphosphospholipid antibodies
OT  - Antiphosphospholipid syndrome
OT  - Lupus nephritis
OT  - SLE
OT  - Systemic lupus erythematosus
OT  - aPL
EDAT- 2020/01/25 06:00
MHDA- 2021/08/03 06:00
CRDT- 2020/01/25 06:00
PHST- 2019/10/03 00:00 [received]
PHST- 2019/12/30 00:00 [accepted]
PHST- 2020/01/25 06:00 [pubmed]
PHST- 2021/08/03 06:00 [medline]
PHST- 2020/01/25 06:00 [entrez]
AID - 10.1007/s40620-019-00698-9 [pii]
AID - 10.1007/s40620-019-00698-9 [doi]
PST - ppublish
SO  - J Nephrol. 2020 Aug;33(4):757-762. doi: 10.1007/s40620-019-00698-9. Epub 2020 Jan 
      23.