PMID- 31975534
OWN - NLM
STAT- MEDLINE
DCOM- 20210510
LR  - 20210510
IS  - 1522-2586 (Electronic)
IS  - 1053-1807 (Linking)
VI  - 52
IP  - 1
DP  - 2020 Jul
TI  - Right and left ventricular interactions, strain, and remodeling in repaired 
      pulmonary stenosis patients with preserved right ventricular ejection fraction: A 
      cardiac magnetic resonance study.
PG  - 129-138
LID - 10.1002/jmri.27034 [doi]
AB  - BACKGROUND: Right ventricular dilation and dysfunction is a common long-term 
      complication in patients with repaired pulmonary stenosis (rPS). Additionally, 
      abnormal right and left ventricular interactions have been reported in 
      right-sided heart defect after intervention, including in pulmonary stenosis. 
      PURPOSE: To analyze ventricular strain, remodeling, and left and right 
      ventricular interactions in rPS patients with preserved right ventricular 
      ejection fraction (RVEF) compared with healthy children using cardiac magnetic 
      resonance. STUDY TYPE: A cross-sectional study. POPULATION: In all, 34 rPS 
      patients and 10 healthy children volunteers (controls). FIELD STRENGTH/SEQUENCE: 
      3.0T/2D balanced steady-state free precession (2D b-SSFP) cine, late gadolinium 
      enhancement (LGE), and 2D phase contrast (2D-PC). ASSESSMENT: Pulmonary 
      regurgitation (PR) fractions of the main pulmonary artery, biventricular volumes, 
      masses, function, and cardiac strain. STATISTICAL TESTS: Mann-Whitney U-test, 
      t-test, Pearson correlation coefficients, Spearman's correlation coefficients, 
      and intraclass correlation coefficients analysis were performed. RESULTS: For 
      group analysis, the right ventricular (RV) global circumferential strain and 
      radial strain were significantly increased in patients when compared with 
      controls (-13.57 +/- 2.69 vs. -5.91 +/- 3.16, P < 0.001; 25.31 +/- 8.12 vs. 
      9.87 +/- 5.32, P < 0.001, respectively). The fraction of PR displayed moderate 
      correlation with right ventricular end-diastolic volume index (RVEDVi) (r = 
      0.452, P = 0.022). RVEDVi and mass index were larger in patients vs. control 
      (104.92 +/- 27.46 vs. 85.15 +/- 11.98, P = 0.016; 18.28 +/- 4.95g/m(2) vs. 11.67 +/- 2.14 
      g/m(2) , P < 0.001, respectively). Patients presented with preserved left 
      ventricular ejection function, but was lower than healthy controls 
      (60.89% +/- 4.89% vs. 65.95% +/- 4.56%, P = 0.006). Regional circumferential strain 
      of segment 3 of left ventricle (LV) were significantly decreased in patients 
      (-7.79 +/- 6.52 vs. -13.56 +/- 3.22, P = 0.003). DATA CONCLUSION: Compensated 
      increased RV strain, myocardial remodeling of RV, and adverse right and left 
      ventricular interactions occur in rPS patients with preserved RVEF. The decreased 
      interventricular septum strain may lead to impaired LV function due to RV 
      dilation as a result of PR. LEVEL OF EVIDENCE: 3 Technical Efficacy Stage: 3 J. 
      Magn. Reson. Imaging 2020;52:129-138.
CI  - (c) 2020 International Society for Magnetic Resonance in Medicine.
FAU - Wang, Shi-Yu
AU  - Wang SY
AD  - Department of Radiology, West China Hospital, West China Medical School, Sichuan 
      University, Chengdu, China.
FAU - OuYang, Rong-Zhen
AU  - OuYang RZ
AD  - Diagnostic Imaging Center, Shanghai Children's Medical Center Affiliated with 
      Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
FAU - Hu, Li-Wei
AU  - Hu LW
AD  - Diagnostic Imaging Center, Shanghai Children's Medical Center Affiliated with 
      Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
FAU - Xie, Wei-Hui
AU  - Xie WH
AD  - Diagnostic Imaging Center, Shanghai Children's Medical Center Affiliated with 
      Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
FAU - Peng, Ya-Feng
AU  - Peng YF
AD  - Diagnostic Imaging Center, Shanghai Children's Medical Center Affiliated with 
      Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
FAU - Wang, Lei
AU  - Wang L
AD  - Department of Radiology, West China Hospital, West China Medical School, Sichuan 
      University, Chengdu, China.
FAU - Gao, Fa-Bao
AU  - Gao FB
AD  - Department of Radiology, West China Hospital, West China Medical School, Sichuan 
      University, Chengdu, China.
FAU - Zhong, Yu-Min
AU  - Zhong YM
AUID- ORCID: 0000-0002-0164-8752
AD  - Diagnostic Imaging Center, Shanghai Children's Medical Center Affiliated with 
      Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200124
PL  - United States
TA  - J Magn Reson Imaging
JT  - Journal of magnetic resonance imaging : JMRI
JID - 9105850
RN  - 0 (Contrast Media)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Child
MH  - Contrast Media
MH  - Cross-Sectional Studies
MH  - Gadolinium
MH  - *Heart Ventricles/diagnostic imaging
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Magnetic Resonance Spectroscopy
MH  - *Pulmonary Valve Stenosis/diagnostic imaging/surgery
MH  - Stroke Volume
MH  - *Tetralogy of Fallot
MH  - *Ventricular Dysfunction, Right/diagnostic imaging
MH  - Ventricular Function, Right
OTO - NOTNLM
OT  - preserved right ventricular ejection fraction
OT  - repaired pulmonary stenosis
OT  - ventricular interactions
OT  - ventricular remodeling
OT  - ventricular strain
EDAT- 2020/01/25 06:00
MHDA- 2021/05/11 06:00
CRDT- 2020/01/25 06:00
PHST- 2019/10/15 00:00 [received]
PHST- 2019/12/10 00:00 [revised]
PHST- 2019/12/11 00:00 [accepted]
PHST- 2020/01/25 06:00 [pubmed]
PHST- 2021/05/11 06:00 [medline]
PHST- 2020/01/25 06:00 [entrez]
AID - 10.1002/jmri.27034 [doi]
PST - ppublish
SO  - J Magn Reson Imaging. 2020 Jul;52(1):129-138. doi: 10.1002/jmri.27034. Epub 2020 
      Jan 24.