PMID- 31975639
OWN - NLM
STAT- MEDLINE
DCOM- 20210624
LR  - 20210624
IS  - 1532-2491 (Electronic)
IS  - 1082-6084 (Print)
IS  - 1082-6084 (Linking)
VI  - 55
IP  - 6
DP  - 2020
TI  - Sources of Misused Prescription Opioids and Their Association with Prescription 
      Opioid Use Disorder in the United States: Sex and Age Differences.
PG  - 928-936
LID - 10.1080/10826084.2020.1713818 [doi]
AB  - Background: Prescription opioid (PO) misuse and prescription opioid use disorder 
      (POUD) are a national crisis in the USA. To inform strategies for reducing the PO 
      epidemic, research is needed on the sources of misused POs and their association 
      with POUD. Methods: Past-year PO misusers aged >/=12 (N = 6033) from the 2015 to 
      2016 National Surveys on Drug Use and Health were analyzed. The most recent 
      source of misused POs was assessed. Logistic regression analyses were used to 
      determine the association between the sources of misused POs and past-year POUD. 
      All analyses were stratified by age groups for each sex. Results: Overall, the 
      most common sources of misused POs were obtaining from friends/relatives for free 
      (40.27%) and physicians (36.59%). Males had a higher prevalence of buying POs 
      from friends/relatives or drug dealers/strangers than females. Significant age 
      differences also emerged. Buying POs from drug dealers/strangers (vs. obtaining 
      POs free from friends/relatives) was strong predictor of past-year POUD in both 
      sexes. In the sex- and age-stratified analyses, significant associations of 
      past-year POUD with (1) buying from drug dealers/strangers emerged among males 
      aged 18+ and females aged 26+; (2) buying from friends/relatives emerged among 
      males aged 12+ and females aged 18-25; (3) obtaining from physicians emerged 
      among males aged 18+ and females aged 26+. Conclusions: Our findings indicate 
      different risk profiles for POUD across sex and age groups with different 
      diversion sources. Prevention and treatment programs for POUD should be tailored 
      to consider sex and developmental age differences in sources of opioids.
FAU - Park, Ji-Yeun
AU  - Park JY
AD  - Department of Psychiatry and Behavioral Sciences, Duke University School of 
      Medicine, Durham, North Carolina, USA.
FAU - Wu, Li-Tzy
AU  - Wu LT
AD  - Department of Psychiatry and Behavioral Sciences, Duke University School of 
      Medicine, Durham, North Carolina, USA.
AD  - Division of General Internal Medicine, Department of Medicine, Duke University 
      School of Medicine, Durham, North Carolina, USA.
AD  - Duke Clinical Research Institute, Duke University School of Medicine, Durham, 
      North Carolina, USA.
AD  - Center for Child and Family Policy, Sanford School of Public Policy, Duke 
      University, Durham, North Carolina, USA.
LA  - eng
GR  - R01 MD007658/MD/NIMHD NIH HHS/United States
GR  - UG1 DA040317/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20200124
PL  - England
TA  - Subst Use Misuse
JT  - Substance use & misuse
JID - 9602153
RN  - 0 (Analgesics, Opioid)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Analgesics, Opioid/therapeutic use
MH  - Female
MH  - Friends
MH  - Humans
MH  - Male
MH  - *Opioid-Related Disorders/drug therapy/epidemiology
MH  - *Prescription Drug Misuse
MH  - Prescriptions
MH  - Prevalence
MH  - United States/epidemiology
MH  - Young Adult
PMC - PMC7166157
MID - NIHMS1555759
OTO - NOTNLM
OT  - Diversion
OT  - age differences
OT  - prescription opioid misuse
OT  - prescription opioid use disorder
OT  - sex differences
EDAT- 2020/01/25 06:00
MHDA- 2021/06/25 06:00
PMCR- 2021/01/24
CRDT- 2020/01/25 06:00
PHST- 2020/01/25 06:00 [pubmed]
PHST- 2021/06/25 06:00 [medline]
PHST- 2020/01/25 06:00 [entrez]
PHST- 2021/01/24 00:00 [pmc-release]
AID - 10.1080/10826084.2020.1713818 [doi]
PST - ppublish
SO  - Subst Use Misuse. 2020;55(6):928-936. doi: 10.1080/10826084.2020.1713818. Epub 
      2020 Jan 24.