PMID- 31976038
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220412
IS  - 1989-5488 (Print)
IS  - 1989-5488 (Electronic)
IS  - 1989-5488 (Linking)
VI  - 12
IP  - 1
DP  - 2020 Jan
TI  - Salivary levels of IgE and ECP in patients with recurrent aphthous stomatitis.
PG  - e9-e12
LID - 10.4317/medoral.56254 [doi]
AB  - BACKGROUND: Recurrent aphthous stomatitis is a common oral mucosa disease, with 
      no specific etiology. Atopy has been implicated in the development of this 
      disease. In this study, the salivary levels of immunoglobulin E (IgE) and 
      eosinophil cationic protein (ECP) were measured as allergy-related biomarkers in 
      patients with aphthous stomatitis. MATERIAL AND METHODS: In this case-control 
      study, non-stimulated saliva was collected from 85 participants and IgE and ECP 
      were measured. Data were analyzed in SPSS 20 through the Mann-Whitney test, and 
      p<0.05 was considered significant. RESULTS: The salivary levels of IgE and ECP 
      were 1.11+/-0.65 Iu/ml and 26.93+/-6.95 ng/ml in the case group and 0.73+/-0/39 Iu/ml 
      and 21.97+/-6.72 ng/ml in the control group. There was a significant difference 
      between the two groups in terms of salivary levels of IgE and ECP (p=0.001). 
      CONCLUSIONS: The results showed that patients with oral aphthous had higher 
      levels of salivary IgE and ECP than controls. Therefore, measurement of these 
      biomarkers may be useful in the initial evaluation of patients with aphthous 
      stomatitis. Key words:Recurrent aphthous stomatitis, saliva, immunoglobulin E, 
      eosinophil cationic protein.
CI  - Copyright: (c) 2020 Medicina Oral S.L.
FAU - Farhad-Mollashahi, Leila
AU  - Farhad-Mollashahi L
AD  - Oral and Maxillofacial Diseases Research Center, Mashhad University of Medical 
      Sciences, Mashhad, Iran.
FAU - Honarmand, Marieh
AU  - Honarmand M
AD  - Oral and Dental Disease Research Center, Department of Oral Medicine, School of 
      Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran.
FAU - Nakhaee, Alireza
AU  - Nakhaee A
AD  - Department of Biochemistry, School of Medicine, Zahedan University of Medical 
      Sciences, Zahedan, Iran.
FAU - Kamalzadeh, Shahram
AU  - Kamalzadeh S
AD  - Dentist, Zahedan University of Medical Sciences, Zahedan, Iran.
FAU - Amini, Sanaz
AU  - Amini S
AD  - Dentist, Zahedan University of Medical Sciences, Zahedan, Iran.
LA  - eng
PT  - Journal Article
DEP - 20200101
PL  - Spain
TA  - J Clin Exp Dent
JT  - Journal of clinical and experimental dentistry
JID - 101603132
PMC - PMC6969959
COIS- Conflicts of interest There was not conflict of interest of financial benefit to 
      any parties involved in this study.
EDAT- 2020/01/25 06:00
MHDA- 2020/01/25 06:01
PMCR- 2020/01/01
CRDT- 2020/01/25 06:00
PHST- 2019/09/01 00:00 [received]
PHST- 2019/11/04 00:00 [accepted]
PHST- 2020/01/25 06:00 [entrez]
PHST- 2020/01/25 06:00 [pubmed]
PHST- 2020/01/25 06:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 56254 [pii]
AID - 10.4317/medoral.56254 [doi]
PST - epublish
SO  - J Clin Exp Dent. 2020 Jan 1;12(1):e9-e12. doi: 10.4317/medoral.56254. eCollection 
      2020 Jan.