PMID- 31977503
OWN - NLM
STAT- MEDLINE
DCOM- 20201231
LR  - 20210206
IS  - 1524-4725 (Electronic)
IS  - 1076-0512 (Linking)
VI  - 46
IP  - 7
DP  - 2020 Jul
TI  - Adverse Events of Injectable Deoxycholic Acid.
PG  - 942-949
LID - 10.1097/DSS.0000000000002318 [doi]
AB  - BACKGROUND: Injectable deoxycholic acid (DCA) may be used to remove excess 
      submental fat and off-label for local adipose reduction. Despite DCA's widespread 
      use, rare incidences of severe, systemic, long-term adverse events (AEs) have 
      been reported. OBJECTIVE: To evaluate the potential side effects associated with 
      injectable DCA. METHODS AND MATERIALS: A systematic review was conducted using 
      PubMed, Cochrane, CINAHL, and Web of Science using PRISMA guidelines to gather 
      the literature relating to DCA or deoxycholate-associated AEs and their 
      management. RESULTS: Twenty-eight manuscripts were included after full article 
      review. Most commonly, patients experienced mild localized AEs, whereas a small 
      number of patients experienced severe pain, alopecia, nasopharyngitis, dysphagia, 
      dizziness/lightheadedness, and gastrointestinal upset. Severe, long-term AEs were 
      reported as rare in the evaluated literature. Deoxycholic acid injections in 
      large volumes were more likely to cause severe adverse effects. CONCLUSION: 
      Self-resolving, mild side effects and severe but rare adverse effects have been 
      reported with DCA use making it a safe treatment for local adipose reduction. 
      Further studies are necessary to determine its safety profile, especially when 
      using DCA in off-label areas.
FAU - Pham, Christine T
AU  - Pham CT
AD  - University of California, Irvine, School of Medicine, Irvine, California.
AD  - Department of Dermatology, University of California, Irvine, Irvine, California.
FAU - Lee, Alfred
AU  - Lee A
AD  - University of California, Riverside, School of Medicine, Riverside, California.
FAU - Sung, Calvin T
AU  - Sung CT
AD  - Department of Dermatology, University of California, Irvine, Irvine, California.
FAU - Choi, Franchesca
AU  - Choi F
AD  - Department of Dermatology, University of California, Irvine, Irvine, California.
FAU - Juhasz, Margit
AU  - Juhasz M
AD  - Department of Dermatology, University of California, Irvine, Irvine, California.
FAU - Mesinkovska, Natasha A
AU  - Mesinkovska NA
AD  - Department of Dermatology, University of California, Irvine, Irvine, California.
LA  - eng
PT  - Journal Article
PT  - Systematic Review
PL  - United States
TA  - Dermatol Surg
JT  - Dermatologic surgery : official publication for American Society for Dermatologic 
      Surgery [et al.]
JID - 9504371
RN  - 005990WHZZ (Deoxycholic Acid)
SB  - IM
MH  - *Cosmetic Techniques
MH  - Deoxycholic Acid/administration & dosage/*adverse effects/therapeutic use
MH  - Humans
MH  - Injections
EDAT- 2020/01/25 06:00
MHDA- 2021/01/01 06:00
CRDT- 2020/01/25 06:00
PHST- 2020/01/25 06:00 [pubmed]
PHST- 2021/01/01 06:00 [medline]
PHST- 2020/01/25 06:00 [entrez]
AID - 00042728-202007000-00017 [pii]
AID - 10.1097/DSS.0000000000002318 [doi]
PST - ppublish
SO  - Dermatol Surg. 2020 Jul;46(7):942-949. doi: 10.1097/DSS.0000000000002318.