PMID- 31977890
OWN - NLM
STAT- MEDLINE
DCOM- 20200131
LR  - 20221005
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 99
IP  - 4
DP  - 2020 Jan
TI  - Intraocular infiltration of Philadelphia chromosome-positive acute lymphoblastic 
      leukemia diagnosed by polymerase chain reaction from the aqueous humor: A case 
      report.
PG  - e18872
LID - 10.1097/MD.0000000000018872 [doi]
LID - e18872
AB  - RATIONALE: Intraocular manifestation of hematopoietic tumors is rare and often 
      difficult to distinguish from inflammation. We report a patient with acute 
      lymphoblastic leukemia (ALL) who developed intraocular infiltration during the 
      remission period. PATIENT CONCERNS: A 40-year-old man presented with hypopyon in 
      his right eye. Three months later, extensive subretinal infiltration and the 
      elevation of intraocular pressure were observed. Fourteen months prior to this, 
      he had been diagnosed with Philadelphia chromosome-positive ALL, and had received 
      chemotherapy and bone marrow transplantation that resulted in complete remission. 
      DIAGNOSIS: The breakpoint cluster region-Ableson (BCR/ABL) chimera was detected 
      by polymerase chain reaction (PCR) analysis in the patient's aqueous humor. 
      Additionally, a high expression of WT1 (Wilms tumor gene) mRNA in the aqueous 
      humor was discovered. A bone marrow examination yielded a high expression of 
      BCR/ABL fusion gene, and it was determined the patient had experienced a relapse 
      of ALL. INTERVENTIONS: The dasatinib was administered orally to the patient. 
      OUTCOMES: The intraocular infiltration disappeared, and intraocular pressure was 
      normalized. LESSONS: Intraocular infiltration in leukemia patients may be an 
      indication of relapse regardless of systemic conditions. Analyzing mRNA 
      expression of BCR/ABL and WT1 of ocular fluid in patients with hypopyon is 
      beneficial in diagnosing topical relapses in leukemia.
FAU - Hiraoka, Miki
AU  - Hiraoka M
AD  - Department of Ophthalmology.
FAU - Ohguro, Hiroshi
AU  - Ohguro H
AD  - Department of Ophthalmology.
FAU - Ikeda, Hiroshi
AU  - Ikeda H
AD  - Department of Oncology and Hematology.
FAU - Furuya, Daisuke
AU  - Furuya D
AD  - Department of Clinical Engineering, Faculty of Health Sciences, Hokkaido 
      University of Science.
FAU - Takahashi, Satoshi
AU  - Takahashi S
AD  - Department of Infection Control and Laboratory Medicine, Sapporo Medical 
      University School of Medicine, Sapporo, Hokkaido, Japan.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Adult
MH  - Aqueous Humor/diagnostic imaging/*metabolism
MH  - Genes, Wilms Tumor
MH  - Humans
MH  - Intraocular Pressure
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*diagnosis/genetics
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - MicroRNAs/metabolism
MH  - Polymerase Chain Reaction
MH  - Recurrence
MH  - Uveitis
PMC - PMC7004763
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2020/01/25 06:00
MHDA- 2020/02/01 06:00
PMCR- 2020/01/24
CRDT- 2020/01/25 06:00
PHST- 2020/01/25 06:00 [entrez]
PHST- 2020/01/25 06:00 [pubmed]
PHST- 2020/02/01 06:00 [medline]
PHST- 2020/01/24 00:00 [pmc-release]
AID - 00005792-202001240-00049 [pii]
AID - MD-D-19-04220 [pii]
AID - 10.1097/MD.0000000000018872 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2020 Jan;99(4):e18872. doi: 10.1097/MD.0000000000018872.