PMID- 31979198
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 1999-4923 (Print)
IS  - 1999-4923 (Electronic)
IS  - 1999-4923 (Linking)
VI  - 12
IP  - 2
DP  - 2020 Jan 22
TI  - Treating Intracranial Abscesses in Rats with Stereotactic Injection of 
      Biodegradable Vancomycin-Embedded Microparticles.
LID - 10.3390/pharmaceutics12020091 [doi]
LID - 91
AB  - Brain abscesses are emergent and life-threating despite advances in modern 
      neurosurgical techniques and antibiotics. The present study explores the efficacy 
      of vancomycin embedded to 50:50 poly(lactic-co-glycolide acid) (PLGA) 
      microparticles in the treatment of brain abscess. The vancomycin embedded 
      microparticles (VMPs) were stereotactically introduced into the cerebral 
      parenchyma in Staphylococcus aureus bacteria- induced brain abscess-bearing rats. 
      Experimental rats were divided into three groups: group A (n = 13; no treatment), 
      group B (n = 14; daily vancomycin injection (5 mg intraperitoneally), and group C 
      (n = 12; stereotactic introduction of VMPs into the abscess cavity). Group C 
      exhibited no inflammatory response and significantly increased survival and 
      reduced mean abscess volumes (p <0.001) at the eighth week, compared with other 
      groups. Vancomycin delivery via a biodegradable PLGA vehicle can easily attain 
      Area Under the Curve (AUC)/minimum inhibitory concentration (MIC) ratios of >/=400, 
      and strengthens the therapeutic efficacy of antibiotics without provoking any 
      potential toxicity. Biodegradable VMPs are a safe and sustainable drug delivery 
      vehicle for the treatment of brain abscess.
FAU - Tseng, Yuan-Yun
AU  - Tseng YY
AD  - Division of Neurosurgery, Department of Surgery, Shuang Ho Hospital, Taipei 
      Medical University, Taipei 11031, Taiwan.
AD  - Department of Surgery, School of Medicine, College of Medicine, Taipei Medical 
      University, Taipei 11031, Taiwan.
FAU - Kao, Ching-Wei
AU  - Kao CW
AD  - Department of Anesthesiology, Chiayi Chang Gung Memorial Hospital, Chiayi 61363, 
      Taiwan.
AD  - Department of Mechanical Engineering, Chang Gung University, Tao-Yuan 33302, 
      Taiwan.
FAU - Liu, Kuo-Sheng
AU  - Liu KS
AD  - Department of Thoracic and Cardiovascular Surgery, Linkou Chang Gung Memorial. 
      Hospital, Taoyuan 33302, Taiwan.
FAU - Tang, Ya-Ling
AU  - Tang YL
AD  - Department of Mechanical Engineering, Chang Gung University, Tao-Yuan 33302, 
      Taiwan.
FAU - Liu, Yen-Wei
AU  - Liu YW
AD  - Department of Thoracic and Cardiovascular Surgery, Linkou Chang Gung Memorial. 
      Hospital, Taoyuan 33302, Taiwan.
FAU - Liu, Shih-Jung
AU  - Liu SJ
AD  - Department of Mechanical Engineering, Chang Gung University, Tao-Yuan 33302, 
      Taiwan.
AD  - Department of Orthopedic Surgery, Chang Gung Memorial Hospital-Linkuo, Tao-Yuan 
      33305, Taiwan.
LA  - eng
GR  - 106-2314-B-038-045-MY2/National Science Council/
GR  - CMRPD2G0251/Chang Gung Memorial Hospital/
PT  - Journal Article
DEP - 20200122
PL  - Switzerland
TA  - Pharmaceutics
JT  - Pharmaceutics
JID - 101534003
PMC - PMC7076644
OTO - NOTNLM
OT  - brain abscess
OT  - drug delivery
OT  - electrospraying
OT  - poly(lactide-co-glycolide acid)
OT  - stereotactic
OT  - vancomycin
COIS- The authors declare no competing financial interest.
EDAT- 2020/01/26 06:00
MHDA- 2020/01/26 06:01
PMCR- 2020/02/01
CRDT- 2020/01/26 06:00
PHST- 2019/12/13 00:00 [received]
PHST- 2020/01/16 00:00 [revised]
PHST- 2020/01/21 00:00 [accepted]
PHST- 2020/01/26 06:00 [entrez]
PHST- 2020/01/26 06:00 [pubmed]
PHST- 2020/01/26 06:01 [medline]
PHST- 2020/02/01 00:00 [pmc-release]
AID - pharmaceutics12020091 [pii]
AID - pharmaceutics-12-00091 [pii]
AID - 10.3390/pharmaceutics12020091 [doi]
PST - epublish
SO  - Pharmaceutics. 2020 Jan 22;12(2):91. doi: 10.3390/pharmaceutics12020091.