PMID- 31979987
OWN - NLM
STAT- MEDLINE
DCOM- 20220530
LR  - 20220601
IS  - 1744-4160 (Electronic)
IS  - 1381-3455 (Linking)
VI  - 128
IP  - 3
DP  - 2022 Jun
TI  - Can gallic acid potentiate the antihyperglycemic effect of acarbose and 
      metformin? Evidence from streptozotocin-induced diabetic rat model.
PG  - 619-627
LID - 10.1080/13813455.2020.1716014 [doi]
AB  - This study investigated the influence of dietary phenolic acid- Gallic acid (GA) 
      on the antihyperglycemic properties of acarbose (ACA) and metformin (MET). 
      Streptozotocin-induced diabetic rats were treated (p.o) with ACA, MET, GA and 
      their combinations for 14 days. The effects of the treatments on blood glucose 
      and insulin levels, pancreas alpha-amylase and intestinal alpha-glucosidase activities, 
      as well as thiobarbituric acid reactive species (TBARS), thiol and reactive 
      oxygen species (ROS) levels, including antioxidant enzyme activities were 
      investigated. A significant increase in blood glucose, insulin, ROS and TBARS 
      levels, and impaired antioxidant status, as well as elevation in the activities 
      of alpha-amylase and alpha-glucosidase observed in diabetic rats were ameliorated in the 
      treatment groups. Hpwever, GA had varying effects on the antidiabetic properties 
      of the drugs. Nevertheless, GA showed more potentiating effects on the 
      antidiabetic effect of MET and these effects were better observed at the lower 
      dose of GA.
FAU - Oboh, Ganiyu
AU  - Oboh G
AUID- ORCID: 0000-0001-5167-9779
AD  - Functional Foods and Nutraceuticals Unit, Department of Biochemistry, Federal 
      University of Technology, Akure, Nigeria.
FAU - Ogunbadejo, Mariam Damilola
AU  - Ogunbadejo MD
AD  - Functional Foods and Nutraceuticals Unit, Department of Biochemistry, Federal 
      University of Technology, Akure, Nigeria.
FAU - Ogunsuyi, Opeyemi Babatunde
AU  - Ogunsuyi OB
AUID- ORCID: 0000-0003-3075-1086
AD  - Functional Foods and Nutraceuticals Unit, Department of Biochemistry, Federal 
      University of Technology, Akure, Nigeria.
AD  - Biomedical Technology Department, Federal University of Technology, Akure, 
      Nigeria.
FAU - Oyeleye, Sunday Idowu
AU  - Oyeleye SI
AUID- ORCID: 0000-0003-3935-2313
AD  - Functional Foods and Nutraceuticals Unit, Department of Biochemistry, Federal 
      University of Technology, Akure, Nigeria.
AD  - Biomedical Technology Department, Federal University of Technology, Akure, 
      Nigeria.
LA  - eng
PT  - Journal Article
DEP - 20200124
PL  - England
TA  - Arch Physiol Biochem
JT  - Archives of physiology and biochemistry
JID - 9510153
RN  - 0 (Antioxidants)
RN  - 0 (Blood Glucose)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
RN  - 0 (Reactive Oxygen Species)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - 5W494URQ81 (Streptozocin)
RN  - 632XD903SP (Gallic Acid)
RN  - 9100L32L2N (Metformin)
RN  - EC 3.2.1.1 (alpha-Amylases)
RN  - EC 3.2.1.20 (alpha-Glucosidases)
RN  - T58MSI464G (Acarbose)
SB  - IM
MH  - Acarbose/pharmacology/therapeutic use
MH  - Animals
MH  - Antioxidants/metabolism
MH  - Blood Glucose
MH  - *Diabetes Mellitus, Experimental/drug therapy
MH  - Gallic Acid/pharmacology/therapeutic use
MH  - Hypoglycemic Agents/pharmacology/therapeutic use
MH  - Insulin
MH  - *Metformin/pharmacology/therapeutic use
MH  - Rats
MH  - Reactive Oxygen Species
MH  - Streptozocin
MH  - Thiobarbituric Acid Reactive Substances
MH  - alpha-Amylases/metabolism
MH  - alpha-Glucosidases/metabolism
OTO - NOTNLM
OT  - Antihyperglycemic
OT  - acarbose
OT  - food-drug interaction
OT  - gallic acid
OT  - metformin
EDAT- 2020/01/26 06:00
MHDA- 2022/05/31 06:00
CRDT- 2020/01/26 06:00
PHST- 2020/01/26 06:00 [pubmed]
PHST- 2022/05/31 06:00 [medline]
PHST- 2020/01/26 06:00 [entrez]
AID - 10.1080/13813455.2020.1716014 [doi]
PST - ppublish
SO  - Arch Physiol Biochem. 2022 Jun;128(3):619-627. doi: 
      10.1080/13813455.2020.1716014. Epub 2020 Jan 24.