PMID- 31980002
OWN - NLM
STAT- MEDLINE
DCOM- 20200806
LR  - 20221207
IS  - 1502-3850 (Electronic)
IS  - 0001-6357 (Linking)
VI  - 78
IP  - 5
DP  - 2020 Jul
TI  - Salivary human beta-defensins and cathelicidin levels in relation to 
      periodontitis and type 2 diabetes mellitus.
PG  - 327-331
LID - 10.1080/00016357.2020.1715471 [doi]
AB  - Objective: Type 2 diabetes mellitus (T2DM) is a well-defined risk factor of 
      periodontitis and it can affect expression of human beta-defensins (hBDs) and 
      cathelicidin (LL-37) as well. The aim of the present study was to evaluate the 
      impact of periodontitis and T2DM on salivary concentrations of these 
      antimicrobial peptides.Material and methods: Unstimulated saliva samples, 
      together with full-mouth periodontal recordings were collected from 92 
      individuals with periodontitis (63 with T2DM and 21 smokers) and 86 periodontally 
      healthy controls (58 with T2DM and 21 smokers). Salivary hBD-1, -2, -3, LL-37, 
      and advanced glycalization end products (AGE) concentrations were measured by 
      enzyme-linked immunosorbent assay.Results: Among the periodontitis patients, T2DM 
      group demonstrated lower levels of hBD-1 (p = .006), hBD-2 (p < .001) and hBD-3 
      (p < .001), and higher levels of LL-37 (p < .001) compared to systemically 
      healthy controls. When only periodontally healthy controls were included into the 
      analysis, higher hBD-1 (p = .002) and LL-37 (p < .001) levels were found in T2DM 
      patients in comparison to systemically healthy controls. Salivary LL-37 levels 
      were associated with HbA1c and periodontitis, while hBD-2, hBD-3 and levels 
      associated only with HbA1c.Conclusion: In the limits of this study, 
      hyperglycaemia can be proposed as a regulator of salivary hBD and cathelicidin 
      levels. Periodontitis, on the other hand, affects only salivary LL-37 levels.
FAU - Yilmaz, Dogukan
AU  - Yilmaz D
AD  - Department of Periodontology, Faculty of Dentistry, Sakarya University, Sakarya, 
      Turkey.
FAU - Topcu, Ali Orkun
AU  - Topcu AO
AD  - Private Practice, Ankara, Turkey.
FAU - Akcay, Emine Ulku
AU  - Akcay EU
AD  - Department of Internal Medicine, Faculty of Medicine, Sakarya University, 
      Sakarya, Turkey.
FAU - Altindis, Mustafa
AU  - Altindis M
AD  - Department of Infectious Disease and Microbiology, Faculty of Medicine, Sakarya 
      University, Sakarya, Turkey.
FAU - Gursoy, Ulvi Kahraman
AU  - Gursoy UK
AD  - Department of Periodontology, Institute of Dentistry, University of Turku, Turku, 
      Finland.
LA  - eng
PT  - Journal Article
DEP - 20200124
PL  - Sweden
TA  - Acta Odontol Scand
JT  - Acta odontologica Scandinavica
JID - 0370344
RN  - 0 (Antimicrobial Cationic Peptides)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (beta-Defensins)
RN  - 0 (hemoglobin A1c protein, human)
RN  - 0 (Cathelicidins)
SB  - IM
MH  - Adult
MH  - Antimicrobial Cationic Peptides/blood/*metabolism
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*blood/complications
MH  - Glycated Hemoglobin
MH  - Humans
MH  - Middle Aged
MH  - Periodontitis/*blood/microbiology/therapy
MH  - Saliva/*chemistry/metabolism
MH  - beta-Defensins/*blood/metabolism
MH  - Cathelicidins
OTO - NOTNLM
OT  - Antimicrobial peptides
OT  - diabetes mellitus
OT  - periodontitis
OT  - saliva
EDAT- 2020/01/26 06:00
MHDA- 2020/08/07 06:00
CRDT- 2020/01/26 06:00
PHST- 2020/01/26 06:00 [pubmed]
PHST- 2020/08/07 06:00 [medline]
PHST- 2020/01/26 06:00 [entrez]
AID - 10.1080/00016357.2020.1715471 [doi]
PST - ppublish
SO  - Acta Odontol Scand. 2020 Jul;78(5):327-331. doi: 10.1080/00016357.2020.1715471. 
      Epub 2020 Jan 24.