PMID- 31982106
OWN - NLM
STAT- MEDLINE
DCOM- 20200908
LR  - 20200908
IS  - 2213-3941 (Electronic)
IS  - 0003-4266 (Linking)
VI  - 81
IP  - 1
DP  - 2020 Feb
TI  - Comparison of 68Ga-Dotatate PET/CT and 18F-FDOPA PET/CT for the diagnosis of 
      pancreatic neuroendocrine tumors in a MEN1 patient.
PG  - 39-43
LID - S0003-4266(19)30235-5 [pii]
LID - 10.1016/j.ando.2019.11.001 [doi]
AB  - CONTEXT: Pancreatic neuroendocrine tumors (PNETs) occur in more than 80% of 
      patients with multiple endocrine neoplasia type 1 (MEN1) syndrome, with 
      predominance of small (<1cm) non-functioning tumors, followed by gastrinomas and 
      insulinomas. Due to their small size, the diagnostic performance of conventional 
      MRI and CT imaging is highly variable, with a real risk of false-negatives. 
      Functional imaging on 111In-DTPA-Octreotide SPECT somatostatin receptor 
      scintigraphy (Octreoscan(R)) is the modality of choice, but shows only 80% 
      sensitivity. Alternatively, 18F-fluorodihydroxyphenylalanine (FDOPA) and, more 
      recently, 68Ga-Dotatate PET/CT imaging are valuable options in case of negative 
      Octreoscan(R). CASE REPORT: A 55 old-year woman diagnosed with MEN1 syndrome, 
      presented with multiple asymptomatic but progressive PNETs revealed on ultrasound 
      endoscopy. Octreoscan(R) was negative, as was 18F-FDOPA PET/CT, whereas 
      68Ga-Dotatate PET/CT detected all PNETs found on endoscopy. CONCLUSION: We here 
      report the first case of a MEN1 patient who successfully underwent a 
      68Ga-Dotatate PET/CT for detection and follow-up of PNETs, while both Octreoscan(R) 
      and 18F-FDOPA PET/CT were negative.
CI  - Copyright (c) 2019 Elsevier Masson SAS. All rights reserved.
FAU - Jullien, Marine
AU  - Jullien M
AD  - Inserm U1251, service d'endocrinologie, Marseille Medical Genetics, Hopital de la 
      Conception, Aix-Marseille Universite, AP-HM, Marseille, France.
FAU - Reichert, Thibault
AU  - Reichert T
AD  - Service de medecine nucleaire, hopital de la Timone, Aix-Marseille Universite, 
      AP-HM, Marseille, France.
FAU - D'Anella, Pascal
AU  - D'Anella P
AD  - Service d'endocrinologie, centre hospitalier d'Avignon, Avignon, France.
FAU - Castinetti, Frederic
AU  - Castinetti F
AD  - Inserm U1251, service d'endocrinologie, Marseille Medical Genetics, Hopital de la 
      Conception, Aix-Marseille Universite, AP-HM, Marseille, France.
FAU - Barlier, Anne
AU  - Barlier A
AD  - Inserm U1251, laboratoire de biologie moleculaire, Marseille Medical Genetics, 
      Hopital de la Conception, Aix-Marseille Universite, AP-HM, Marseille, France.
FAU - Brue, Thierry
AU  - Brue T
AD  - Inserm U1251, service d'endocrinologie, Marseille Medical Genetics, Hopital de la 
      Conception, Aix-Marseille Universite, AP-HM, Marseille, France.
FAU - Taieb, David
AU  - Taieb D
AD  - Service de medecine nucleaire, hopital de la Timone, Aix-Marseille Universite, 
      AP-HM, Marseille, France.
FAU - Cuny, Thomas
AU  - Cuny T
AD  - Inserm U1251, service d'endocrinologie, Marseille Medical Genetics, Hopital de la 
      Conception, Aix-Marseille Universite, AP-HM, Marseille, France. Electronic 
      address: thomas.cuny@ap-hm.fr.
LA  - eng
PT  - Case Reports
PT  - Comparative Study
PT  - Journal Article
DEP - 20191216
PL  - France
TA  - Ann Endocrinol (Paris)
JT  - Annales d'endocrinologie
JID - 0116744
RN  - 0 (Organometallic Compounds)
RN  - 2C598205QX (fluorodopa F 18)
RN  - 63-84-3 (Dihydroxyphenylalanine)
RN  - 9L17Y0H71P (gallium Ga 68 dotatate)
SB  - IM
MH  - Dihydroxyphenylalanine/*analogs & derivatives
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/complications/*diagnosis/pathology
MH  - Neuroendocrine Tumors/complications/*diagnosis/pathology
MH  - *Organometallic Compounds
MH  - Pancreatic Neoplasms/complications/*diagnosis/pathology
MH  - Positron Emission Tomography Computed Tomography/*methods
OTO - NOTNLM
OT  - (18)F-FDOPA TEP/TDM
OT  - 18F-FDOPA PET/CT
OT  - 68(Ga)-DOTATATE TEP/TDM
OT  - 68Ga-Dotatate PET/CT
OT  - MEN1
OT  - NEM1
OT  - Neuroendocrine
OT  - Pancreas
OT  - Pancreas
EDAT- 2020/01/27 06:00
MHDA- 2020/09/09 06:00
CRDT- 2020/01/27 06:00
PHST- 2019/06/21 00:00 [received]
PHST- 2019/11/01 00:00 [revised]
PHST- 2019/11/16 00:00 [accepted]
PHST- 2020/01/27 06:00 [pubmed]
PHST- 2020/09/09 06:00 [medline]
PHST- 2020/01/27 06:00 [entrez]
AID - S0003-4266(19)30235-5 [pii]
AID - 10.1016/j.ando.2019.11.001 [doi]
PST - ppublish
SO  - Ann Endocrinol (Paris). 2020 Feb;81(1):39-43. doi: 10.1016/j.ando.2019.11.001. 
      Epub 2019 Dec 16.