PMID- 31982367
OWN - NLM
STAT- MEDLINE
DCOM- 20210524
LR  - 20240423
IS  - 2405-4720 (Electronic)
IS  - 2405-4712 (Print)
IS  - 2405-4712 (Linking)
VI  - 10
IP  - 2
DP  - 2020 Feb 26
TI  - Molecular and Functional Networks Linked to Sarcopenia Prevention by Caloric 
      Restriction in Rhesus Monkeys.
PG  - 156-168.e5
LID - S2405-4712(19)30463-6 [pii]
LID - 10.1016/j.cels.2019.12.002 [doi]
AB  - Caloric restriction (CR) improves survival in nonhuman primates and delays the 
      onset of age-related morbidities including sarcopenia, which is characterized by 
      the age-related loss of muscle mass and function. A shift in metabolism 
      anticipates the onset of muscle-aging phenotypes in nonhuman primates, suggesting 
      a potential role for metabolism in the protective effects of CR. Here, we show 
      that CR induced profound changes in muscle composition and the cellular metabolic 
      environment. Bioinformatic analysis linked these adaptations to proteostasis, RNA 
      processing, and lipid synthetic pathways. At the tissue level, CR maintained 
      contractile content and attenuated age-related metabolic shifts among individual 
      fiber types with higher mitochondrial activity, altered redox metabolism, and 
      smaller lipid droplet size. Biometric and metabolic rate data confirm preserved 
      metabolic efficiency in CR animals that correlated with the attenuation of 
      age-related muscle mass and physical activity. These data suggest that CR-induced 
      reprogramming of metabolism plays a role in delayed aging of skeletal muscle in 
      rhesus monkeys.
CI  - Copyright (c) 2019 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Rhoads, Timothy W
AU  - Rhoads TW
AD  - Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA.
FAU - Clark, Josef P
AU  - Clark JP
AD  - Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA.
FAU - Gustafson, Grace E
AU  - Gustafson GE
AD  - Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA.
FAU - Miller, Karl N
AU  - Miller KN
AD  - Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA.
FAU - Conklin, Matthew W
AU  - Conklin MW
AD  - Department of Cell and Regenerative Biology, University of Wisconsin-Madison, 
      Madison, WI 53706, USA.
FAU - DeMuth, Tyler M
AU  - DeMuth TM
AD  - Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA.
FAU - Berres, Mark E
AU  - Berres ME
AD  - Biotechnolgoy Center, University of Wisconsin-Madison, Madison, WI 53705, USA.
FAU - Eliceiri, Kevin W
AU  - Eliceiri KW
AD  - Laboratory for Optical and Computational Instrumentation, University of 
      Wisconsin-Madison, Madison, WI 53706, USA.
FAU - Vaughan, Laura K
AU  - Vaughan LK
AD  - Department of Biostatistics, University of Alabama-Birmingham, Birmingham, AL 
      35294, USA.
FAU - Lary, Christine W
AU  - Lary CW
AD  - Department of Biostatistics, University of Alabama-Birmingham, Birmingham, AL 
      35294, USA.
FAU - Beasley, T Mark
AU  - Beasley TM
AD  - Department of Biostatistics, University of Alabama-Birmingham, Birmingham, AL 
      35294, USA; Geriatric Research Education and Clinical Center, Birmingham/Atlanta 
      Veterans Administration Hospital, Birmingham, AL 35297, USA.
FAU - Colman, Ricki J
AU  - Colman RJ
AD  - Department of Cell and Regenerative Biology, University of Wisconsin-Madison, 
      Madison, WI 53706, USA; Wisconsin National Primate Research Center, University of 
      Wisconsin-Madison, Madison, WI 53715, USA.
FAU - Anderson, Rozalyn M
AU  - Anderson RM
AD  - Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA; 
      Geriatric Research Education and Clinical Center, William S. Middleton Memorial 
      Veterans Hospital, Madison, WI 53705, USA. Electronic address: 
      rozalyn.anderson@wisc.edu.
LA  - eng
GR  - R01 AG037000/AG/NIA NIH HHS/United States
GR  - R01 AG040178/AG/NIA NIH HHS/United States
GR  - T32 AG000213/AG/NIA NIH HHS/United States
GR  - R56 AG047358/AG/NIA NIH HHS/United States
GR  - P01 AG011915/AG/NIA NIH HHS/United States
GR  - I01 BX003846/BX/BLRD VA/United States
GR  - T32 DK007665/DK/NIDDK NIH HHS/United States
GR  - P51 OD011106/OD/NIH HHS/United States
GR  - C06 RR020141/RR/NCRR NIH HHS/United States
GR  - C06 RR015459/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20200122
PL  - United States
TA  - Cell Syst
JT  - Cell systems
JID - 101656080
SB  - IM
MH  - Adult
MH  - Animals
MH  - Caloric Restriction
MH  - Humans
MH  - Macaca mulatta
MH  - Male
MH  - Molecular Medicine
MH  - Sarcopenia/*prevention & control
PMC - PMC7047532
MID - NIHMS1068808
OTO - NOTNLM
OT  - caloric restriction
OT  - metabolic networks
OT  - rhesus monkeys
OT  - sarcopenia
OT  - skeletal muscle aging
COIS- Declaration of Interests The authors declare no competing interests.
EDAT- 2020/01/27 06:00
MHDA- 2021/05/25 06:00
PMCR- 2020/02/28
CRDT- 2020/01/27 06:00
PHST- 2019/04/08 00:00 [received]
PHST- 2019/08/03 00:00 [revised]
PHST- 2019/12/11 00:00 [accepted]
PHST- 2020/01/27 06:00 [pubmed]
PHST- 2021/05/25 06:00 [medline]
PHST- 2020/01/27 06:00 [entrez]
PHST- 2020/02/28 00:00 [pmc-release]
AID - S2405-4712(19)30463-6 [pii]
AID - 10.1016/j.cels.2019.12.002 [doi]
PST - ppublish
SO  - Cell Syst. 2020 Feb 26;10(2):156-168.e5. doi: 10.1016/j.cels.2019.12.002. Epub 
      2020 Jan 22.