PMID- 31982877
OWN - NLM
STAT- MEDLINE
DCOM- 20201221
LR  - 20201221
IS  - 1662-8063 (Electronic)
IS  - 1662-4246 (Linking)
VI  - 23
IP  - 1-2
DP  - 2020
TI  - ABCA1 Variants rs1800977 (C69T) and rs9282541 (R230C) Are Associated with 
      Susceptibility to Type 2 Diabetes.
PG  - 20-25
LID - 10.1159/000505344 [doi]
AB  - OBJECTIVE: Accumulated evidence suggests that ATP-binding cassette A1 transporter 
      (ABCA1) contributes to secreting insulin in pancreatic beta-cells and amyloid beta 
      formation. This study aimed to investigate the association between three single 
      nucleotide polymorphisms (SNPs) of ABCA1 and susceptibility to type 2 diabetes 
      mellitus (T2DM) in a Han Chinese population. METHODS: A total of 996 T2DM 
      patients and 1,002 controls were included in the study. Three SNPs in the ABCA1 
      gene, i.e., rs2230806 (R219K), rs1800977 (C69T), and rs9282541 (R230C), were 
      genotyped by SNaPshot. A genotype model, an allele model, a dominant model, and a 
      recessive model were used to assess susceptibility to T2DM. RESULTS: There were 
      significant associations between rs1800977 and T2DM in different genetic models 
      (TT vs. CC, OR = 0.591 [0.446-0.793], p < 0.001; T vs. C, OR = 0.835 
      [0.735-0.949], p = 0.006; recessive model, OR = 0.583 [0.449-0.756], p < 0.001). 
      There were also significant associations between rs9282541 and T2DM in different 
      genetic models (CT vs. CC, OR = 1.690 [0.807-1.005], p = 0.048; T vs. C, OR = 
      1.756 [0.694-1.060], p = 0.029; dominant model, OR = 1.735 [0.715-1.034], p = 
      0.037). CONCLUSION: Our case-control study showed that the two SNPs rs1800977 and 
      rs9282541 in the ABCA1 gene are significantly associated with susceptibility to 
      T2DM in our Han Chinese population. Study of further mechanisms should be 
      performed before application to clinical therapy.
CI  - (c) 2020 S. Karger AG, Basel.
FAU - Du, Weiping
AU  - Du W
AD  - Department of Clinical Laboratory, Affiliated Hospital of Yan'an University, 
      Yan'an, China.
FAU - Hu, Zhixi
AU  - Hu Z
AD  - Department of Clinical Laboratory, Affiliated Hospital of Yan'an University, 
      Yan'an, China.
FAU - Wang, Li
AU  - Wang L
AD  - Department of Clinical Laboratory, Affiliated Hospital of Yan'an University, 
      Yan'an, China.
FAU - Li, Miaomiao
AU  - Li M
AD  - Department of Clinical Laboratory, Affiliated Hospital of Yan'an University, 
      Yan'an, China.
FAU - Zhao, Dong
AU  - Zhao D
AD  - Department of Clinical Laboratory, Affiliated Hospital of Yan'an University, 
      Yan'an, China.
FAU - Li, Hui
AU  - Li H
AD  - Department of Clinical Laboratory, Affiliated Hospital of Yan'an University, 
      Yan'an, China.
FAU - Wei, Junsheng
AU  - Wei J
AD  - Department of Clinical Laboratory, Affiliated Hospital of Yan'an University, 
      Yan'an, China.
FAU - Zhang, Rui
AU  - Zhang R
AD  - Department of Clinical Laboratory, Affiliated Hospital of Yan'an University, 
      Yan'an, China, zr2019049@163.com.
LA  - eng
PT  - Journal Article
DEP - 20200124
PL  - Switzerland
TA  - Public Health Genomics
JT  - Public health genomics
JID - 101474167
RN  - 0 (ABCA1 protein, human)
RN  - 0 (ATP Binding Cassette Transporter 1)
SB  - IM
MH  - ATP Binding Cassette Transporter 1/*genetics
MH  - Case-Control Studies
MH  - China/epidemiology
MH  - *Diabetes Mellitus, Type 2/epidemiology/genetics
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genetic Testing/methods
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
OTO - NOTNLM
OT  - ABCA1
OT  - Single nucleotide polymorphism
OT  - Type 2 diabetes mellitus
EDAT- 2020/01/27 06:00
MHDA- 2020/12/22 06:00
CRDT- 2020/01/27 06:00
PHST- 2019/09/17 00:00 [received]
PHST- 2019/11/22 00:00 [accepted]
PHST- 2020/01/27 06:00 [pubmed]
PHST- 2020/12/22 06:00 [medline]
PHST- 2020/01/27 06:00 [entrez]
AID - 000505344 [pii]
AID - 10.1159/000505344 [doi]
PST - ppublish
SO  - Public Health Genomics. 2020;23(1-2):20-25. doi: 10.1159/000505344. Epub 2020 Jan 
      24.