PMID- 31982890
OWN - NLM
STAT- MEDLINE
DCOM- 20201103
LR  - 20201103
IS  - 1643-3750 (Electronic)
IS  - 1234-1010 (Print)
IS  - 1234-1010 (Linking)
VI  - 26
DP  - 2020 Jan 26
TI  - Echocardiographic Changes in Newly Diagnosed Type 2 Diabetes Mellitus Patients 
      with and without Hypertension.
PG  - e918972
LID - 10.12659/MSM.918972 [doi]
AB  - BACKGROUND Whether type 2 diabetes mellitus (T2DM) is independently associated 
      with structural heart abnormalities is controversial because of confounders 
      associated with T2DM. This study aimed to investigate echocardiographic features 
      in patients with newly diagnosed T2DM, exploring changes in cardiac structure and 
      function. MATERIAL AND METHODS This was a retrospective study of new T2DM cases 
      treated at the Second People's Hospital Affiliated to Nanjing Medical University 
      (Changzhou) in 2014-2016. In all, 128 T2DM cases were included (62 hypertensive 
      and 66 non-hypertensive individuals). Controls were selected among individuals 
      who underwent examination at the same department/period. Interventricular septal 
      thickness (IVST), left ventricular end-diastolic diameter (LVEDD), posterior left 
      ventricular wall thickness (PWTD), left ventricle mass (LVM), end-diastolic 
      thickness of left ventricular posterior wall (Dd), aortic root diameter, left 
      atrial diameter (LAd), left atrial diameter fraction-shortening values, and left 
      ventricular ejection fraction (LVEF) were determined routinely. RESULTS IVST, 
      LVEDD, PWTD, Dd, LAd, and left atrial diameter fraction-shortening values were 
      larger in patients with T2DM (all P<0.05 vs. controls). LVM was higher in T2DM 
      patients (median, 57.12 vs. 54.77 g, P=0.001). There were no differences in 
      aortic root diameter and EF (both P>0.05). Multivariable analysis showed that 
      IVST (OR=1.33, 95% CI: 1.01-1.76, P=0.04), LAd (OR=1.16, 95% CI: 1.07-1.25, 
      P<0.001), TGs (OR=1.34, 95% CI: 1.09-1.63, P=0.005), and HDL (OR=1.46, 95% CI: 
      1.02-2.08, P=0.04) were independently associated with hypertension in patients 
      with T2DM. CONCLUSIONS Patients with newly diagnosed T2DM already display 
      structural heart abnormalities. LAd and IVST are independently associated with 
      hypertension in these patients, probably contributing to increased cardiovascular 
      risk.
FAU - Zhao, Zhen
AU  - Zhao Z
AD  - Department of Endocrinology, The Affiliated Changzhou No. 2 People's Hospital of 
      Nanjing Medical University, Changzhou, Jiangsu, China (mainland).
FAU - Hou, Can
AU  - Hou C
AD  - Department of Cardiology, The Affiliated Changzhou No. 2 People's Hospital of 
      Nanjing Medical University, Changzhou, Jiangsu, China (mainland).
FAU - Ye, Xinhua
AU  - Ye X
AD  - Department of Endocrinology, The Affiliated Changzhou No. 2 People's Hospital of 
      Nanjing Medical University, Changzhou, Jiangsu, China (mainland).
FAU - Cheng, Jinluo
AU  - Cheng J
AD  - Department of Endocrinology, The Affiliated Changzhou No. 2 People's Hospital of 
      Nanjing Medical University, Changzhou, Jiangsu, China (mainland).
LA  - eng
PT  - Journal Article
DEP - 20200126
PL  - United States
TA  - Med Sci Monit
JT  - Medical science monitor : international medical journal of experimental and 
      clinical research
JID - 9609063
SB  - IM
MH  - Diabetes Mellitus, Type 2/*complications/diagnosis/*diagnostic imaging
MH  - *Echocardiography
MH  - Female
MH  - Humans
MH  - Hypertension/*complications/diagnosis/*diagnostic imaging
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
PMC - PMC7001517
COIS- Conflict of interests None.
EDAT- 2020/01/27 06:00
MHDA- 2020/11/04 06:00
PMCR- 2020/01/26
CRDT- 2020/01/27 06:00
PHST- 2020/01/27 06:00 [entrez]
PHST- 2020/01/27 06:00 [pubmed]
PHST- 2020/11/04 06:00 [medline]
PHST- 2020/01/26 00:00 [pmc-release]
AID - 918972 [pii]
AID - 10.12659/MSM.918972 [doi]
PST - epublish
SO  - Med Sci Monit. 2020 Jan 26;26:e918972. doi: 10.12659/MSM.918972.