PMID- 31983010
OWN - NLM
STAT- MEDLINE
DCOM- 20201211
LR  - 20201214
IS  - 1573-6903 (Electronic)
IS  - 0364-3190 (Linking)
VI  - 45
IP  - 4
DP  - 2020 Apr
TI  - Oligodendrocytes Death Induced Sensorimotor and Cognitive Deficit in 
      N-nitro-L-arginine methyl Rat Model of Pre-eclampsia.
PG  - 902-914
LID - 10.1007/s11064-020-02969-5 [doi]
AB  - Pre-eclampsia (PE) is a pregnancy complicated syndrome that affects multiple 
      organs including the brain that continue post- delivery in both mother and the 
      offspring. We evaluated the expression of oligodendrocytes in the brain of PE rat 
      model through development as well as the cognitive changes and other behavioural 
      modifications that may occur later in the life of offspring of PE-like rat model. 
      Pregnant rats divided into early-onset and late-onset groups were administered 
      with N-nitro- L-arginine methyl (L-NAME) through drinking water at gestational 
      days (GD) 8-17. Rats were allowed free access to water throughout the pregnancy. 
      At GD 19, post-natal day (PND) 1 and 60, rats were sacrificed and brain excised 
      for further analysis. The offspring were subjected to behavioural studies for 
      cognitive and sensorimotor impairments before sacrificed at PND 60. Results 
      showed significant down-regulation in the expression of OLIG2 in PE at GD 19 
      brain which persists till PND 60. Likewise, there was a significant increase in 
      the latency to locate the platform in Morris water maze, time to traverse the 
      balance beam and reduced hanging time on the wire test between the control and 
      the PE treated. PE could lead to impaired neuronal signalling through 
      demyelination which may contributes significantly to long-term sensorimotor and 
      cognitive deficit.
FAU - Ijomone, Olayemi K
AU  - Ijomone OK
AUID- ORCID: 0000-0003-4430-6530
AD  - Optics and Imaging Centre, Doris Duke Medical Research Institute, College of 
      Health Sciences, University of KwaZulu-Natal, Durban, South Africa. 
      215082646@stu.ukzn.ac.za.
FAU - Shallie, Philemon Dauda
AU  - Shallie PD
AD  - Optics and Imaging Centre, Doris Duke Medical Research Institute, College of 
      Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
FAU - Naicker, Thajasvarie
AU  - Naicker T
AD  - Optics and Imaging Centre, Doris Duke Medical Research Institute, College of 
      Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
LA  - eng
PT  - Journal Article
DEP - 20200125
PL  - United States
TA  - Neurochem Res
JT  - Neurochemical research
JID - 7613461
RN  - 0 (Olig2 protein, rat)
RN  - 0 (Oligodendrocyte Transcription Factor 2)
RN  - V55S2QJN2X (NG-Nitroarginine Methyl Ester)
SB  - IM
MH  - Animals
MH  - Apoptosis/*physiology
MH  - Cerebellum/metabolism/pathology
MH  - Cerebral Cortex/metabolism/pathology
MH  - Cognitive Dysfunction/etiology/*physiopathology
MH  - Down-Regulation
MH  - Female
MH  - Male
MH  - Memory/physiology
MH  - Morris Water Maze Test/physiology
MH  - NG-Nitroarginine Methyl Ester
MH  - Oligodendrocyte Transcription Factor 2/metabolism
MH  - Oligodendroglia/*metabolism
MH  - Pre-Eclampsia/chemically induced/*physiopathology
MH  - Pregnancy
MH  - Pregnancy Complications/etiology/*physiopathology
MH  - Rats, Sprague-Dawley
OTO - NOTNLM
OT  - Demyelination
OT  - Long-term cognitive deficit
OT  - Oligodendrocytes
OT  - Pregnancy complication
EDAT- 2020/01/27 06:00
MHDA- 2020/12/15 06:00
CRDT- 2020/01/27 06:00
PHST- 2019/07/04 00:00 [received]
PHST- 2020/01/20 00:00 [accepted]
PHST- 2019/12/17 00:00 [revised]
PHST- 2020/01/27 06:00 [pubmed]
PHST- 2020/12/15 06:00 [medline]
PHST- 2020/01/27 06:00 [entrez]
AID - 10.1007/s11064-020-02969-5 [pii]
AID - 10.1007/s11064-020-02969-5 [doi]
PST - ppublish
SO  - Neurochem Res. 2020 Apr;45(4):902-914. doi: 10.1007/s11064-020-02969-5. Epub 2020 
      Jan 25.