PMID- 31983089
OWN - NLM
STAT- MEDLINE
DCOM- 20200630
LR  - 20200630
IS  - 2241-6293 (Electronic)
IS  - 1107-0625 (Linking)
VI  - 24
IP  - 6
DP  - 2019 Nov-Dec
TI  - Mechanisms of C-myc oncogenic activity in head and neck squamous cell carcinoma.
PG  - 2242-2244
AB  - Laryngeal squamous cell carcinoma (LSCC) demonstrates increased rates due to 
      pathogenetic factors including tobacco, chronic alcohol consumption and also 
      viral-mediated deregulation. During carcinogenetic process, laryngeal epithelia 
      accumulate gross chromosome and specific gene aberrations. Oncogenes' 
      overactivation is a crucial genetic event in malignant and pre-malignant 
      neoplastic epithelia. Among oncogenes, C-myc (gene locus: 8q24.12-q24.13) acts as 
      a strong transcription factor, implicated in the control of cell differentiation 
      and apoptosis. Upregulation of the gene - due to increased copy numbers 
      (amplification) - seems to be correlated with aggressive biological behaviour in 
      LSCCs. In the current special molecular article we explored the role of C-myc 
      deregulation in LSCC.
FAU - Mastronikolis, Nicholas
AU  - Mastronikolis N
AD  - Department of Pathology, Anticancer Oncologic Hospital "Saint Savvas", Athens, 
      Greece.
FAU - Ragos, Vasileios
AU  - Ragos V
FAU - Kyrodimos, Efthymios
AU  - Kyrodimos E
FAU - Chrysovergis, Aristeidis
AU  - Chrysovergis A
FAU - Papanikolaou, Vasileios
AU  - Papanikolaou V
FAU - Mastronikolis, Stylianos
AU  - Mastronikolis S
FAU - Stamatelopoulos, Athanasios
AU  - Stamatelopoulos A
FAU - Tsiambas, Evangelos
AU  - Tsiambas E
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Cyprus
TA  - J BUON
JT  - Journal of B.U.ON. : official journal of the Balkan Union of Oncology
JID - 100883428
SB  - IM
MH  - Carcinoma, Squamous Cell/*genetics/pathology
MH  - Cell Line, Tumor
MH  - Genes, myc/*genetics
MH  - Head and Neck Neoplasms/*genetics/pathology
MH  - Humans
MH  - Oncogenes/*genetics
EDAT- 2020/01/27 06:00
MHDA- 2020/07/01 06:00
CRDT- 2020/01/27 06:00
PHST- 2020/01/27 06:00 [entrez]
PHST- 2020/01/27 06:00 [pubmed]
PHST- 2020/07/01 06:00 [medline]
PST - ppublish
SO  - J BUON. 2019 Nov-Dec;24(6):2242-2244.