PMID- 3198336
OWN - NLM
STAT- MEDLINE
DCOM- 19890124
LR  - 20190820
IS  - 0020-9996 (Print)
IS  - 0020-9996 (Linking)
VI  - 23 Suppl 1
DP  - 1988 Sep
TI  - Vasodilatation and vasoconstriction in the rabbit isolated aorta. Effects of 
      ioxilan, iohexol, and diatrizoate.
PG  - S150-2
AB  - The vasomotor effects of contrast media (CM), ioxilan, iohexol, and diatrizoate, 
      and their isoosmotic sucrose solutions as controls, were studied in vitro in 
      rings of thoracic aortas of rabbits. When the osmotic pressure of CM or controls 
      reached the region of 380 mOsm/kg, vasoconstriction developed, reaching a maximum 
      in about 1 hour; it was reversible. It could not be blocked by phentolamine, and 
      therefore did not involve alpha-adrenoceptors. When added to aortic rings 
      precontracted with noradrenaline, all of the CM produced vasodilatation, while 
      reactions to sucrose varied. When endothelium was removed, CM still produced 
      vasodilatation, suggesting a direct chemotoxic effect on smooth muscle. The 
      dilatation effect does not involve the muscarinic receptors, beta-adrenoceptors, 
      or stimulation of prostacyclin synthesis, since the vasodilator response was not 
      blocked by atropine, propranolol, or indomethacin. Blockage of calcium channels 
      did not appear to be a contributing factor. Since the dilator response to all CM 
      was augmented in the presence of the phosphodiesterase inhibitor, 
      iso-butylmethylxanthine (IBMX), it is likely that CM produce vasodilatation 
      chemotoxically by activating the production of a cyclic nucleotide.
FAU - Schneider, K M
AU  - Schneider KM
AD  - Department of Pharmacology, University of Melbourne, Victoria, Australia.
FAU - Rand, M J
AU  - Rand MJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Invest Radiol
JT  - Investigative radiology
JID - 0045377
RN  - 0 (Contrast Media)
RN  - 117-96-4 (Diatrizoate)
RN  - 4419T9MX03 (Iohexol)
RN  - A4YJ7J11TG (ioxilan)
SB  - IM
MH  - Animals
MH  - Aorta, Thoracic
MH  - Contrast Media/*pharmacology
MH  - Diatrizoate/*pharmacology
MH  - Iohexol/*analogs & derivatives/*pharmacology
MH  - Osmolar Concentration
MH  - Rabbits
MH  - Vasoconstriction/*drug effects
MH  - Vasodilation/*drug effects
EDAT- 1988/09/01 00:00
MHDA- 1988/09/01 00:01
CRDT- 1988/09/01 00:00
PHST- 1988/09/01 00:00 [pubmed]
PHST- 1988/09/01 00:01 [medline]
PHST- 1988/09/01 00:00 [entrez]
AID - 10.1097/00004424-198809001-00023 [doi]
PST - ppublish
SO  - Invest Radiol. 1988 Sep;23 Suppl 1:S150-2. doi: 10.1097/00004424-198809001-00023.