PMID- 31983436
OWN - NLM
STAT- MEDLINE
DCOM- 20200923
LR  - 20211204
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 524
IP  - 1
DP  - 2020 Mar 26
TI  - Transcriptional coactivator with PDZ-binding motif stimulates epidermal 
      regeneration via induction of amphiregulin expression after ultraviolet damage.
PG  - 242-248
LID - S0006-291X(20)30148-0 [pii]
LID - 10.1016/j.bbrc.2020.01.079 [doi]
AB  - Ultraviolet (UV) irradiation induces the proliferation and differentiation of 
      keratinocytes in the basal layer of the epidermis, which increases epidermal 
      thickness in skin regeneration. However, the mechanism underlying this phenomenon 
      is not yet known in detail. In this study, we aimed to demonstrate that the 
      transcriptional coactivator with PDZ-binding motif (TAZ) stimulates epidermal 
      regeneration by increasing keratinocyte proliferation. During epidermal 
      regeneration, TAZ is localized in the nucleus of keratinocytes of the basal layer 
      and stimulates epidermal growth factor receptor (EGFR) signaling. TAZ depletion 
      in keratinocytes decreased EGFR signaling activation, which delays epidermal 
      regeneration. Interestingly, TAZ stimulated the transcription of amphiregulin 
      (AREG), a ligand of EGFR, through TEAD-mediated transcriptional activation. 
      Together, these results show that TAZ stimulates EGFR signaling through AREG 
      induction, suggesting that it plays an important role in epidermal regeneration.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Kim, Kyung Min
AU  - Kim KM
AD  - Division of Life Sciences, School of Life Sciences and Biotechnology, Korea 
      University, Seoul, 02841, South Korea.
FAU - Oh, Ho Taek
AU  - Oh HT
AD  - Division of Life Sciences, School of Life Sciences and Biotechnology, Korea 
      University, Seoul, 02841, South Korea.
FAU - Yoo, Gi Don
AU  - Yoo GD
AD  - Division of Life Sciences, School of Life Sciences and Biotechnology, Korea 
      University, Seoul, 02841, South Korea.
FAU - Hwang, Jun-Ha
AU  - Hwang JH
AD  - Division of Life Sciences, School of Life Sciences and Biotechnology, Korea 
      University, Seoul, 02841, South Korea.
FAU - Oh, Areum
AU  - Oh A
AD  - College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans 
      University, Seoul, 03760, South Korea.
FAU - Hwang, Eun Sook
AU  - Hwang ES
AD  - College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans 
      University, Seoul, 03760, South Korea; Ewha Education & Research Center for 
      Infection, Ewha Womans University, Seoul, 03760, South Korea. Electronic address: 
      eshwang@ewha.ac.kr.
FAU - Hong, Jeong-Ho
AU  - Hong JH
AD  - Division of Life Sciences, School of Life Sciences and Biotechnology, Korea 
      University, Seoul, 02841, South Korea. Electronic address: jh_hong@korea.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200123
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Amphiregulin)
RN  - 0 (Ligands)
RN  - 0 (Trans-Activators)
RN  - 0 (Wwtr1 protein, mouse)
RN  - EC 2.7.10.1 (ErbB Receptors)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing
MH  - Amphiregulin/*genetics/metabolism
MH  - Animals
MH  - Cell Proliferation/radiation effects
MH  - Epidermis/*physiology/radiation effects
MH  - ErbB Receptors/metabolism
MH  - Gene Deletion
MH  - Humans
MH  - Keratinocytes/metabolism/radiation effects
MH  - Ligands
MH  - Male
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - *Regeneration/radiation effects
MH  - Signal Transduction/radiation effects
MH  - Trans-Activators/*metabolism
MH  - *Transcription, Genetic/radiation effects
MH  - *Ultraviolet Rays
OTO - NOTNLM
OT  - AREG
OT  - EGFR signal
OT  - Skin regeneration
OT  - UV damage
COIS- Declaration of competing interest The authors declare that they have no conflicts 
      of interest.
EDAT- 2020/01/28 06:00
MHDA- 2020/09/24 06:00
CRDT- 2020/01/28 06:00
PHST- 2019/12/24 00:00 [received]
PHST- 2020/01/15 00:00 [accepted]
PHST- 2020/01/28 06:00 [pubmed]
PHST- 2020/09/24 06:00 [medline]
PHST- 2020/01/28 06:00 [entrez]
AID - S0006-291X(20)30148-0 [pii]
AID - 10.1016/j.bbrc.2020.01.079 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2020 Mar 26;524(1):242-248. doi: 
      10.1016/j.bbrc.2020.01.079. Epub 2020 Jan 23.