PMID- 31983918
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220412
IS  - 1658-3639 (Print)
IS  - 1658-7774 (Electronic)
IS  - 1658-3639 (Linking)
VI  - 14
IP  - 1
DP  - 2020 Jan-Feb
TI  - Effect of bacillus bacterial extracts on the expression of major 
      histocompatibility complex Class I and Class II receptors on MDA-MB 231 breast 
      cancer cells.
PG  - 24-34
AB  - OBJECTIVE: The expression of human leukocyte antigen (HLA)-ABC and HLA-DR is 
      linked to the development of breast cancer. This study was aimed to determine the 
      effect of bacillus bacterial extracts on the expression of the major 
      histocompatibility complexes (MHC) Class I and Class II receptors on breast 
      cancer cells. METHODS: The expression of HLA-ABC and HLA-DR was assessed by flow 
      cytometry and confocal microscope on the human breast tumor cell lines 
      MDA-MB-231, which used a readily accessible model system. It is postulated that 
      the HLA-ABC and HLA-DR receptors might be regulated by bacillus bacterial 
      extracts designated (RA10, RA4, RA7, and RA16). RESULTS: It was observed that the 
      treatment of cell line MDA-MB-231 with the RA10 resulted in an upregulation of 
      the cell surface expression of the HLA-A, B, C receptors. It was observed that 
      RA10 has the capacity to reduce the expression of HLA-A, B, C, it also shows a 
      detectable degree of cytotoxicity when used at high concentrations. The data show 
      that the cell surface expression of HLA-ABC is higher than HLA-DR. No significant 
      changes of HLA-DR expression were observed on MDA-MB-231 cell lines. CONCLUSIONS: 
      Improved understanding of the connection between HLA-ABC, HLA-DR, and bacterial 
      extracts such as RA10 may lead to the development of drug design and therapies 
      related to breast cancer condition in which these receptors are involved.
CI  - Copyright: (c) International Journal of Health Sciences.
FAU - Alabdulmonem, Waleed
AU  - Alabdulmonem W
AD  - Department of Pathology, College of Medicine, Qassim University, Buraidah, 
      Kingdom of Saudi Arabia.
LA  - eng
PT  - Journal Article
PL  - Saudi Arabia
TA  - Int J Health Sci (Qassim)
JT  - International journal of health sciences
JID - 101528042
PMC - PMC6968881
OTO - NOTNLM
OT  - Bacillus bacterial extracts
OT  - breast cancer cells
OT  - major histocompatibility complexes Class I receptor
OT  - major histocompatibility complexes Class II receptor
EDAT- 2020/01/28 06:00
MHDA- 2020/01/28 06:01
PMCR- 2020/01/01
CRDT- 2020/01/28 06:00
PHST- 2020/01/28 06:00 [entrez]
PHST- 2020/01/28 06:00 [pubmed]
PHST- 2020/01/28 06:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - IJHS-14-24 [pii]
PST - ppublish
SO  - Int J Health Sci (Qassim). 2020 Jan-Feb;14(1):24-34.