PMID- 31985601
OWN - NLM
STAT- MEDLINE
DCOM- 20210322
LR  - 20210322
IS  - 1536-0210 (Electronic)
IS  - 0020-9996 (Linking)
VI  - 55
IP  - 5
DP  - 2020 May
TI  - HLA-DRB1*15: 02 Is Associated With Iodinated Contrast Media-Related Anaphylaxis.
PG  - 304-309
LID - 10.1097/RLI.0000000000000644 [doi]
AB  - BACKGROUND: The incidence of severe reaction induced by iodinated contrast media 
      (ICM) has increased over the years with an increasing use of imaging modalities. 
      Although ICM anaphylaxis is rare, it can be life-threatening, but currently, 
      there is no biomarker that can identify individuals at risk of ICM anaphylaxis. 
      OBJECTIVE: The aim of this study is to investigate the genetic susceptibility of 
      ICM anaphylaxis. METHODS: Patients who had ICM anaphylaxis were enrolled in the 
      study, and their blood samples were collected for genotyping of human leukocyte 
      antigen (HLA)-A, -B, -C, and -DR. The results were compared with those of healthy 
      Korean general population. MRGPRX2 gene in ICM anaphylaxis group was also 
      sequenced and compared with the Korean standard database of genetic polymorphism. 
      RESULTS: The frequencies of 3 HLA alleles (B*52:01, C*12:02, and DRB1*15:02) were 
      significantly higher in 47 patients with ICM anaphylaxis. In particular, 
      HLA-DRB1*15:02 was 5 times more frequent in the ICM anaphylaxis group than the 
      Korean general population (34.0% vs 6.6%; odds ratio, 7.306; 95% confidence 
      interval, 3.622-14.740), and this difference was most pronounced in subjects with 
      iohexol-induced anaphylaxis (odds ratio, 16.516; 95% CI, 5.241-52.047; P < 
      0.0001). Eight single nucleotide polymorphisms were identified in MRGPRX2 gene, 
      but their frequencies were not different in those with ICM anaphylaxis compared 
      with the general Korean population. CONCLUSIONS: HLA-DRB1*15:02 is associated 
      with ICM anaphylaxis in the Korean population.
FAU - Chung, Soo Jie
AU  - Chung SJ
FAU - Kang, Dong Yoon
AU  - Kang DY
FAU - Lee, Whal
AU  - Lee W
AD  - Radiology.
FAU - Lee, Seung Bok
AU  - Lee SB
AD  - Pediatrics, Seoul National University College of Medicine, Seoul.
FAU - Kim, Sujeong
AU  - Kim S
AD  - Department of Internal Medicine, School of Medicine, Kyungpook National 
      University, Daegu.
FAU - Lee, Seung-Eun
AU  - Lee SE
AD  - Department of Internal Medicine, Pusan National University Yangsan Hospital, 
      Yangsan.
FAU - Sim, Da Woon
AU  - Sim DW
AD  - Division of Allergy, Asthma and Clinical Immunology, Department of Internal 
      Medicine, Chonnam National University Medical School, Gwangju.
FAU - Kang, Min-Gyu
AU  - Kang MG
AD  - Department of Internal Medicine, Chung-Buk National University Hospital, Chungju.
FAU - Park, Kyung Hee
AU  - Park KH
AD  - Department of Internal Medicine, Yonsei University College of Medicine.
FAU - Jung, Jae-Woo
AU  - Jung JW
AD  - Department of Internal Medicine, Chung-Ang University Hospital, Seoul, South 
      Korea.
FAU - Yun, James
AU  - Yun J
FAU - Kang, Hye-Ryun
AU  - Kang HR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Invest Radiol
JT  - Investigative radiology
JID - 0045377
RN  - 0 (Contrast Media)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Receptors, G-Protein-Coupled)
RN  - 0 (Receptors, Neuropeptide)
RN  - 4419T9MX03 (Iohexol)
SB  - IM
MH  - Anaphylaxis/*chemically induced/genetics/metabolism
MH  - Case-Control Studies
MH  - Contrast Media/adverse effects
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - HLA-DRB1 Chains/*genetics/metabolism
MH  - Humans
MH  - Iohexol/*adverse effects
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Receptors, G-Protein-Coupled/genetics
MH  - Receptors, Neuropeptide/genetics
EDAT- 2020/01/28 06:00
MHDA- 2021/03/23 06:00
CRDT- 2020/01/28 06:00
PHST- 2020/01/28 06:00 [pubmed]
PHST- 2021/03/23 06:00 [medline]
PHST- 2020/01/28 06:00 [entrez]
AID - 00004424-202005000-00007 [pii]
AID - 10.1097/RLI.0000000000000644 [doi]
PST - ppublish
SO  - Invest Radiol. 2020 May;55(5):304-309. doi: 10.1097/RLI.0000000000000644.