PMID- 31985784
OWN - NLM
STAT- MEDLINE
DCOM- 20210625
LR  - 20210625
IS  - 1532-2092 (Electronic)
IS  - 1099-5129 (Linking)
VI  - 22
IP  - 3
DP  - 2020 Mar 1
TI  - A novel multielectrode catheter for high-density ventricular mapping: electrogram 
      characterization and utility for scar mapping.
PG  - 440-449
LID - 10.1093/europace/euz364 [doi]
AB  - AIMS: Multielectrode mapping catheters can be advantageous for identifying 
      surviving myocardial bundles in scar. This study aimed to evaluate the utility of 
      a new multielectrode catheter with increased number of small and closely spaced 
      electrodes for mapping ventricles with healed infarction. METHODS AND RESULTS: In 
      12 swine (four healthy and eight with infarction), the left ventricle was mapped 
      with investigational (OctarayTM) and standard (PentarayTM) multielectrode mapping 
      catheters. The investigational catheter has more electrodes (48 vs. 20), each 
      with a smaller surface area (0.9 vs. 2.0 mm2) and spacing is fixed at 2 mm (vs. 
      2-6-2 mm). Electrogram (EGM) characteristics, mapping efficiency and scar 
      description were compared between the catheters and late gadolinium enhancement 
      (LGE). Electrogram acquisition rate was faster with the investigational catheter 
      (814 +/- 126 vs. 148 +/- 58 EGM/min, P = 0.02) resulting in higher density maps 
      (38 +/- 10.3 vs. 10.1 +/- 10.4 EGM/cm2, P = 0.02). Bipolar voltage amplitude was 
      similar between the catheters in normal and infarcted myocardium (P = 0.265 and 
      P = 0.44) and the infarct surface area was similar between the catheters 
      (P = 0.12) and corresponded to subendocardial LGE. The investigational catheter 
      identified a higher proportion of near-field local abnormal ventricular 
      activities within the low-voltage area (53 +/- 16% vs. 34 +/- 16%, P = 0.03) that 
      were considered far-field EGMs by the standard catheter. The investigational 
      catheter was also advantageous for mapping haemodymically non-tolerated 
      ventricular tachycardias due to its higher acquisition rate (P < 0.001). 
      CONCLUSION: A novel multielectrode mapping catheter with higher number of small, 
      and closely spaced electrodes increases the mapping speed, EGM density and the 
      ability to recognize low amplitude near-field EGMs in ventricles with healed 
      infarction.
CI  - Published on behalf of the European Society of Cardiology. All rights reserved. (c) 
      The Author(s) 2020. For permissions, please email: journals.permissions@oup.com.
FAU - Barkagan, Michael
AU  - Barkagan M
AD  - Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical 
      Center, Harvard Medical School, Harvard-Thorndike Electrophysiology Institute, 
      185 Pilgrim Road, Baker 4, Boston, MA 02215, USA.
FAU - Sroubek, Jakub
AU  - Sroubek J
AD  - Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical 
      Center, Harvard Medical School, Harvard-Thorndike Electrophysiology Institute, 
      185 Pilgrim Road, Baker 4, Boston, MA 02215, USA.
FAU - Shapira-Daniels, Ayelet
AU  - Shapira-Daniels A
AD  - Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical 
      Center, Harvard Medical School, Harvard-Thorndike Electrophysiology Institute, 
      185 Pilgrim Road, Baker 4, Boston, MA 02215, USA.
FAU - Yavin, Hagai
AU  - Yavin H
AD  - Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical 
      Center, Harvard Medical School, Harvard-Thorndike Electrophysiology Institute, 
      185 Pilgrim Road, Baker 4, Boston, MA 02215, USA.
FAU - Jang, Jihye
AU  - Jang J
AD  - Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical 
      Center, Harvard Medical School, Boston, MA, USA.
FAU - Nezafat, Reza
AU  - Nezafat R
AD  - Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical 
      Center, Harvard Medical School, Boston, MA, USA.
AD  - Department of Medicine, Cancer Research Institute, Beth Israel Deaconess Medical 
      Center, Harvard Medical School, Boston, MA, USA.
FAU - Anter, Elad
AU  - Anter E
AD  - Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical 
      Center, Harvard Medical School, Harvard-Thorndike Electrophysiology Institute, 
      185 Pilgrim Road, Baker 4, Boston, MA 02215, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Europace
JT  - Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal 
      of the working groups on cardiac pacing, arrhythmias, and cardiac cellular 
      electrophysiology of the European Society of Cardiology
JID - 100883649
RN  - 0 (Contrast Media)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Animals
MH  - *Catheter Ablation
MH  - Catheters
MH  - Cicatrix/pathology
MH  - Contrast Media
MH  - Gadolinium
MH  - Heart Ventricles/diagnostic imaging/pathology
MH  - Swine
MH  - *Tachycardia, Ventricular/diagnosis/pathology
OTO - NOTNLM
OT  - Scar
OT  - Catheters
OT  - Electrodes
OT  - High-density mapping
OT  - Mapping
OT  - Substrate mapping
OT  - Ventricular tachycardia
EDAT- 2020/01/28 06:00
MHDA- 2021/06/29 06:00
CRDT- 2020/01/28 06:00
PHST- 2019/11/12 00:00 [received]
PHST- 2019/12/02 00:00 [revised]
PHST- 2019/12/19 00:00 [accepted]
PHST- 2020/01/28 06:00 [pubmed]
PHST- 2021/06/29 06:00 [medline]
PHST- 2020/01/28 06:00 [entrez]
AID - 5716369 [pii]
AID - 10.1093/europace/euz364 [doi]
PST - ppublish
SO  - Europace. 2020 Mar 1;22(3):440-449. doi: 10.1093/europace/euz364.