PMID- 31985829
OWN - NLM
STAT- MEDLINE
DCOM- 20201006
LR  - 20211204
IS  - 1749-6632 (Electronic)
IS  - 0077-8923 (Linking)
VI  - 1467
IP  - 1
DP  - 2020 May
TI  - Molecular regulation of autophagy machinery by mTOR-dependent and -independent 
      pathways.
PG  - 3-20
LID - 10.1111/nyas.14305 [doi]
AB  - Macroautophagy is a lysosomal degradative pathway or recycling process that 
      maintains cellular homeostasis. This autophagy involves a series of sequential 
      processing events, such as initiation; elongation and nucleation of the isolation 
      membrane; cargo recruitment and maturation of the autophagosome (AP); transport 
      of the AP; docking and fusion of the AP with a late endosome or lysosome; and 
      regeneration of the lysosome by the autophagic lysosomal reformation cycle. These 
      events are critically coordinated by the action of a set of several key 
      components, including autophagy-related proteins (Atg), and regulated by 
      intricate networks, such as mechanistic target of rapamycin (mTOR), a master 
      regulator of autophagy, as well as mTOR-independent signaling pathways. Among 
      mTOR-independent pathways, the transient receptor potential (TRP) calcium ion 
      channel TRPML (mucolipin) subfamily is emerging as an important signaling channel 
      to modulate lysosomal biogenesis and autophagy. This review discusses the recent 
      advances in elucidating the molecular mechanisms and regulation of the autophagy 
      process. Understanding these mechanisms may ultimately allow scientists and 
      clinicians to control this process in order to improve human health.
CI  - (c) 2020 New York Academy of Sciences.
FAU - Al-Bari, Md Abdul Alim
AU  - Al-Bari MAA
AUID- ORCID: 0000-0002-1777-3662
AD  - Department of Pharmacy, University of Rajshahi, Rajshahi, Bangladesh.
FAU - Xu, Pingyong
AU  - Xu P
AD  - Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of 
      Sciences, Beijing, China.
AD  - Beijing Key Laboratory of Noncoding RNA, Institute of Biophysics, Chinese Academy 
      of Sciences, Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200127
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 0 (Amino Acids)
RN  - 0 (Transient Receptor Potential Channels)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Amino Acids/metabolism
MH  - Animals
MH  - Autophagy/*physiology
MH  - Calcium/metabolism
MH  - Humans
MH  - Signal Transduction/*physiology
MH  - TOR Serine-Threonine Kinases/*metabolism
MH  - Transient Receptor Potential Channels/metabolism
OTO - NOTNLM
OT  - TRPML
OT  - amino acid sensing
OT  - autophagy regulation
OT  - calcium channel
OT  - mTOR signaling
OT  - macroautophagy
OT  - miRNA
EDAT- 2020/01/28 06:00
MHDA- 2020/10/07 06:00
CRDT- 2020/01/28 06:00
PHST- 2019/08/11 00:00 [received]
PHST- 2019/11/23 00:00 [revised]
PHST- 2020/01/07 00:00 [accepted]
PHST- 2020/01/28 06:00 [pubmed]
PHST- 2020/10/07 06:00 [medline]
PHST- 2020/01/28 06:00 [entrez]
AID - 10.1111/nyas.14305 [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2020 May;1467(1):3-20. doi: 10.1111/nyas.14305. Epub 2020 Jan 
      27.