PMID- 31988850
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2228-5652 (Print)
IS  - 2228-5660 (Electronic)
IS  - 2228-5652 (Linking)
VI  - 10
IP  - 1
DP  - 2020
TI  - Therapeutic impacts of enzyme-responsive smart nanobiosystems.
PG  - 1-4
LID - 10.15171/bi.2020.01 [doi]
AB  - An important arena of the sophisticated nanosystems (NSs) is the combination of 
      the responsive features of NSs with the biocatalytic properties of enzymes. The 
      development of such smart drug delivery systems (DDSs) has seminal effectiveness 
      in targeting, imaging, and monitoring of cancer. These NSs can exhibit 
      site-specific delivery of the toxic cargo in response to the endogenous/exogenous 
      stimuli. Enzyme responsive/targeted DDSs display enhanced accumulation of cargo 
      molecules in the tumor microenvironment (TME) with a spatiotemporal 
      controlled-release behavior. Based on the unique features of enzyme 
      responsive/targeted DDSs, they offer incredible promise in overcoming some 
      limitations of the currently used conventional DDSs. Taken all, targeting TME 
      with the enzyme-responsive targeted DDSs may lead to versatile clinical outcomes 
      in various malignancies.
CI  - (c) 2020 The Author(s).
FAU - Fathi, Marziyeh
AU  - Fathi M
AUID- ORCID: 0000-0001-5710-6365
AD  - Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz 
      University of Medical Sciences, Tabriz, Iran.
FAU - Safary, Azam
AU  - Safary A
AUID- ORCID: 0000-0002-8997-2003
AD  - Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz 
      University of Medical Sciences, Tabriz, Iran.
AD  - Connective Tissue Diseases Research Center, Tabriz University of Medical 
      Sciences, Tabriz, Iran.
FAU - Barar, Jaleh
AU  - Barar J
AUID- ORCID: 0000-0002-0105-919X
AD  - Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz 
      University of Medical Sciences, Tabriz, Iran.
AD  - Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical 
      Sciences, Tabriz, Iran.
LA  - eng
PT  - Editorial
DEP - 20191125
PL  - Iran
TA  - Bioimpacts
JT  - BioImpacts : BI
JID - 101558125
PMC - PMC6977590
OTO - NOTNLM
OT  - Enzyme-responsive
OT  - Nanomaterial
OT  - Smart drug delivery system
OT  - Stimuli-responsive
OT  - Tumor targeting
EDAT- 2020/01/29 06:00
MHDA- 2020/01/29 06:01
PMCR- 2020/01/01
CRDT- 2020/01/29 06:00
PHST- 2019/09/11 00:00 [received]
PHST- 2019/10/21 00:00 [revised]
PHST- 2019/11/11 00:00 [accepted]
PHST- 2020/01/29 06:00 [entrez]
PHST- 2020/01/29 06:00 [pubmed]
PHST- 2020/01/29 06:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.15171/bi.2020.01 [doi]
PST - ppublish
SO  - Bioimpacts. 2020;10(1):1-4. doi: 10.15171/bi.2020.01. Epub 2019 Nov 25.