PMID- 31988860
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220412
IS  - 2231-5047 (Print)
IS  - 2231-5128 (Electronic)
IS  - 2231-5047 (Linking)
VI  - 9
IP  - 1
DP  - 2019 Jan-Jun
TI  - Nonalcoholic Fatty Liver Diseases among Recently Diagnosed Patients with Diabetes 
      Mellitus and Risk Factors.
PG  - 9-13
LID - 10.5005/jp-journals-10018-1288 [doi]
AB  - AIM: Prevalence of obesity and type 2 diabetes mellitus (T2DM), both of which 
      represent are related to nonalcoholic fatty liver disease (NAFLD), is an 
      increasing trend among Asian people. The study aimed to assess the prevalence of 
      NAFLD in T2DM with their risk factors in the Southern part of Pakistan. MATERIALS 
      AND METHODS: A cross-sectional study was accomplished during 2008-2013 at The Aga 
      Khan University Hospital, Karachi, Pakistan. Adult patients diagnosed with T2DM 
      during last 6 months were enrolled in this study. NAFLD was identified using 
      ultrasound of the liver. Clinical and biochemical relevant measurements were 
      accomplished. RESULTS: Out of a total of 203 patients with T2DM, NAFLD was 
      detected in 146 patients (71.9%). Multivariate analysis revealed that NAFLD was 
      significantly associated with dyslipidemia (OR 2.38, 95% CI 1.06-5.34, p = 
      0.035), higher LDL (OR 1.02, 95%CI 1.01-1.03, p = 0.003), H bA1c (OR1.27, 95% CI 
      0.97-1.68, p = 0.045) and diastolic blood pressure (OR 1.05, 95% CI 1.01-1.10, p 
      = 0.009). The highest odds of 10.8 for NAFLD (95% CI 4.9-24, p = 0.001) was found 
      for the combination of hypertension, dyslipidemia, body mass index (BMI), waist 
      circumference, lack of physical inactivity, triglycerides, lower HDL, LDL, HbA1c, 
      and ALT (multiplicative analysis). CONCLUSION: High incidence of NAFLD with the 
      association of different lifestyle-related factors has been analyzed. It unmasks 
      the need for screening for NAFLD in newly diagnosed DM patients in Pakistan with 
      the assessment of parameters of risk factors. HOW TO CITE THIS ARTICLE: Butt AS, 
      Hamid S, et al. Nonalcoholic fatty Liver Diseases Among Recently Diagnosed 
      Patients With Diabetes Mellitus and Risk Factors. Euroasian J Hepatogastroenterol 
      2019;9(1):9-13.
CI  - Copyright (c) 2019; Jaypee Brothers Medical Publishers (P) Ltd.
FAU - Butt, Amna S
AU  - Butt AS
AD  - Section of Gastroenterology, Department of Medicine, Aga Khan University 
      Hospital, Karachi, Pakistan.
FAU - Hamid, Saeed
AU  - Hamid S
AD  - Section of Gastroenterology, Department of Medicine, Aga Khan University 
      Hospital, Karachi, Pakistan.
FAU - Haider, Zishan
AU  - Haider Z
AD  - Department of Radiology, Aga Khan University Hospital, Karachi, Pakistan.
FAU - Sharif, Fatima
AU  - Sharif F
AD  - Aga Khan University, Karachi, Pakistan.
FAU - Salih, Mohammad
AU  - Salih M
AD  - Section of Gastroenterology, Department of Medicine, Aga Khan University 
      Hospital, Karachi, Pakistan.
FAU - Awan, Safia
AU  - Awan S
AD  - Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan.
FAU - Khan, Aatif A
AU  - Khan AA
AD  - Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan.
FAU - Akhter, Jaweed
AU  - Akhter J
AD  - Section of Endocrinology, Department of Medicine, Aga Khan University Hospital, 
      Karachi, Pakistan.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Euroasian J Hepatogastroenterol
JT  - Euroasian journal of hepato-gastroenterology
JID - 101577625
PMC - PMC6969327
OTO - NOTNLM
OT  - Diabetes mellitus
OT  - Nonalcoholic fatty liver disease
OT  - Prevalence
OT  - Risk factors
COIS- Source of support: Supported by University Research Council, Aga Khan University, 
      Karachi, Pakistan Conflict of interest: None
EDAT- 2020/01/29 06:00
MHDA- 2020/01/29 06:01
PMCR- 2019/01/01
CRDT- 2020/01/29 06:00
PHST- 2020/01/29 06:00 [entrez]
PHST- 2020/01/29 06:00 [pubmed]
PHST- 2020/01/29 06:01 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - 10.5005/jp-journals-10018-1288 [doi]
PST - ppublish
SO  - Euroasian J Hepatogastroenterol. 2019 Jan-Jun;9(1):9-13. doi: 
      10.5005/jp-journals-10018-1288.