PMID- 31988901
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2296-6870 (Electronic)
IS  - 2296-6870 (Linking)
VI  - 2
IP  - 1
DP  - 2017 Jan-Apr
TI  - Rapid Regression of Obstructive Cardiac Rhabdomyoma in a Preterm Neonate after 
      Sirolimus Therapy.
PG  - 1-6
LID - 10.1159/000460813 [doi]
AB  - Cardiac rhabdomyoma can be subclinical or fatal depending on the onset age, 
      involving site, and the size and degree of invasion. Although most rhabdomyomas 
      become smaller with time, emergency intervention is indicated when severe 
      obstruction induces hemodynamic instability. Mammalian target of rapamycin (mTOR) 
      inhibitors have been used to treat neonates and children with hemodynamically 
      obstructive cardiac rhabdomyoma. Herein, we report a premature neonate at the 
      gestational age of 30 + 4 weeks with severe left ventricular outflow tract 
      obstructive cardiac rhabdomyoma who was successfully treated with the mTOR 
      inhibitor sirolimus. To the best of our knowledge, this is the first recorded 
      case of a premature neonate with obstructive cardiac rhabdomyoma who was 
      successfully treated with an mTOR inhibitor. Therefore, sirolimus could be 
      considered as an alternative medical option for managing premature neonates with 
      obstructive cardiac rhabdomyoma.
CI  - Copyright (c) 2017 by S. Karger AG, Basel.
FAU - Lee, Seung Jae
AU  - Lee SJ
AD  - Department of Pediatrics, Chonnam National University Hospital, Chonnam National 
      University Medical School, Gwangju, South Korea.
FAU - Song, Eun Song
AU  - Song ES
AD  - Department of Pediatrics, Chonnam National University Hospital, Chonnam National 
      University Medical School, Gwangju, South Korea.
FAU - Cho, Hwa Jin
AU  - Cho HJ
AD  - Department of Pediatrics, Chonnam National University Hospital, Chonnam National 
      University Medical School, Gwangju, South Korea.
FAU - Choi, Young Youn
AU  - Choi YY
AD  - Department of Pediatrics, Chonnam National University Hospital, Chonnam National 
      University Medical School, Gwangju, South Korea.
FAU - Ma, Jae Sook
AU  - Ma JS
AD  - Department of Pediatrics, KS Hospital, Gwangju, South Korea.
FAU - Cho, Young Kuk
AU  - Cho YK
AD  - Department of Pediatrics, Chonnam National University Hospital, Chonnam National 
      University Medical School, Gwangju, South Korea.
LA  - eng
PT  - Case Reports
DEP - 20170321
PL  - Switzerland
TA  - Biomed Hub
JT  - Biomedicine hub
JID - 101692630
PMC - PMC6945939
OTO - NOTNLM
OT  - Cardiac rhabdomyoma
OT  - Left ventricle inlet obstruction
OT  - Tuberous sclerosis
EDAT- 2017/03/21 00:00
MHDA- 2017/03/21 00:01
PMCR- 2017/03/21
CRDT- 2020/01/29 06:00
PHST- 2017/01/25 00:00 [received]
PHST- 2017/02/08 00:00 [accepted]
PHST- 2020/01/29 06:00 [entrez]
PHST- 2017/03/21 00:00 [pubmed]
PHST- 2017/03/21 00:01 [medline]
PHST- 2017/03/21 00:00 [pmc-release]
AID - bmh-0002-0001 [pii]
AID - 10.1159/000460813 [doi]
PST - epublish
SO  - Biomed Hub. 2017 Mar 21;2(1):1-6. doi: 10.1159/000460813. eCollection 2017 
      Jan-Apr.