PMID- 31989271
OWN - NLM
STAT- MEDLINE
DCOM- 20210209
LR  - 20210209
IS  - 1434-4726 (Electronic)
IS  - 0937-4477 (Print)
IS  - 0937-4477 (Linking)
VI  - 277
IP  - 4
DP  - 2020 Apr
TI  - Establishing the minimal clinically important difference (MCID) of the Zurich 
      Chronic Middle Ear Inventory (ZCMEI-21) in patients treated for chronic middle 
      ear disease.
PG  - 1039-1044
LID - 10.1007/s00405-020-05819-w [doi]
AB  - AIM: To determine the minimal clinically important difference (MCID) of the 
      Zurich Chronic Middle Ear Inventory (ZCMEI-21), a questionnaire assessing 
      health-related quality of life (HRQoL) in chronic otitis media (COM). METHODS: In 
      this longitudinal study, 103 patients completed the ZCMEI-21 before and after 
      surgery for chronic otitis media. An anchor-based method including a global 
      rating of change (GRC) was used to assess the MCID of the ZCMEI-21. RESULTS: A 
      total of 103 patients were included. The mean preoperative and postoperative 
      ZCMEI-21 scores were 28.6 (SD 13.6), and 21.8 (SD 12.8), respectively. The mean 
      change was 6.8 (SD 0.8; p < 0.0001). A significant correlation between the 
      ZCMEI-21 scores and the GRC was found (r =  - 0.5; p < 0.001). Using the 
      anchor-based method, the MCID of the ZCMEI-21 was estimated at 5.3 (SD 12.0). 
      CONCLUSIONS: Knowledge of values indicating a clinically relevant change in 
      patient-reported outcome measures is important when interpreting effects of 
      different treatment modalities. This is the first study assessing the MCID of a 
      questionnaire measuring HRQoL in COM, i.e. the ZCMEI-21. We recommend a MCID of 5 
      in COM patients undergoing surgical treatment. This information substantially 
      increases the usefulness of the ZCMEI-21 as an outcome measure in COM as changes 
      can be assessed with regard to their clinical meaningfulness.
FAU - Bachinger, David
AU  - Bachinger D
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital 
      Zurich, Zurich, Switzerland.
AD  - University of Zurich, Zurich, Switzerland.
FAU - Mlynski, Robert
AU  - Mlynski R
AD  - Department of Otorhinolaryngology, Head and Neck Surgery "Otto Korner", 
      University Medical Center, Doberaner Strasse 137-139, 18057, Rostock, Germany.
FAU - Weiss, Nora M
AU  - Weiss NM
AUID- ORCID: 0000-0002-0645-3591
AD  - Department of Otorhinolaryngology, Head and Neck Surgery "Otto Korner", 
      University Medical Center, Doberaner Strasse 137-139, 18057, Rostock, Germany. 
      nora-magdalena.weiss@med.uni-rostock.de.
LA  - eng
PT  - Journal Article
DEP - 20200127
PL  - Germany
TA  - Eur Arch Otorhinolaryngol
JT  - European archives of oto-rhino-laryngology : official journal of the European 
      Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the 
      German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
JID - 9002937
SB  - IM
MH  - Adult
MH  - Aged
MH  - Chronic Disease
MH  - Ear, Middle/*surgery
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - *Minimal Clinically Important Difference
MH  - *Otitis Media/surgery
MH  - Otologic Surgical Procedures
MH  - Patient Reported Outcome Measures
MH  - Prospective Studies
MH  - *Quality of Life
MH  - Treatment Outcome
PMC - PMC7072039
OTO - NOTNLM
OT  - COM
OT  - Chronic otitis media
OT  - HRQoL
OT  - MCID
OT  - Quality of life
COIS- The authors declare no conflict of interest.
EDAT- 2020/01/29 06:00
MHDA- 2021/02/10 06:00
PMCR- 2020/01/27
CRDT- 2020/01/29 06:00
PHST- 2019/12/10 00:00 [received]
PHST- 2020/01/20 00:00 [accepted]
PHST- 2020/01/29 06:00 [pubmed]
PHST- 2021/02/10 06:00 [medline]
PHST- 2020/01/29 06:00 [entrez]
PHST- 2020/01/27 00:00 [pmc-release]
AID - 10.1007/s00405-020-05819-w [pii]
AID - 5819 [pii]
AID - 10.1007/s00405-020-05819-w [doi]
PST - ppublish
SO  - Eur Arch Otorhinolaryngol. 2020 Apr;277(4):1039-1044. doi: 
      10.1007/s00405-020-05819-w. Epub 2020 Jan 27.