PMID- 31989422
OWN - NLM
STAT- MEDLINE
DCOM- 20210322
LR  - 20230426
IS  - 1931-7565 (Electronic)
IS  - 1931-7557 (Linking)
VI  - 14
IP  - 6
DP  - 2020 Dec
TI  - Patterns of intrinsic brain activity in essential tremor with resting tremor and 
      tremor-dominant Parkinson's disease.
PG  - 2606-2617
LID - 10.1007/s11682-019-00214-4 [doi]
AB  - The clinical pictures of essential tremor (ET) with resting tremor (rET) and 
      tremor-dominant Parkinson's disease (tPD) are often quite mimic at the early 
      stage, current approaches to the diagnosis and treatment therefore remain 
      challenging. The regional homogeneity (ReHo) method under resting-state 
      functional magnetic resonance imaging (rs-fMRI) would help exhibit the patterns 
      in neural activity, which further contribute to differentiate these disorders and 
      explore the relationship between symptoms and regional functional abnormalities. 
      Sixty-eight Chinese participants were recruited, including 19 rET patients, 24 
      tPD patients and 25 age- and gender-matched healthy controls (HCs). All 
      participants underwent clinical assessment and rs-fMRI with a ReHo method to 
      investigate the alterations of neural activity, and the correlation between them. 
      Differences were compared by two-sample t-test (corrected with AlphaSim, 
      p < 0.05). Compared with HCs, patients' groups both displayed decreased ReHo in 
      the default mode network (DMN), bilateral putamen and bilateral cerebellum. While 
      tPD patients specifically exihibited decreased ReHo in the bilateral 
      supplementary motor area (SMA) and precentral gyrus (M1). The correlation 
      analysis revealed that ReHo in the bilateral putamen, right SMA and left 
      cerebellum_crus I were negatively correlated with the UPDRS-III score, 
      respectively, in tPD group. Our results indicated the rET patients may share part 
      of the pathophysiological mechanism of tPD patients. In addition, we found 
      disorder-specific involvement of the SMA and M1 in tPD. Such a distinction may 
      lend itself to use as a potential biomarker for differentiating between these two 
      diseases.
FAU - Li, Jun-Ying
AU  - Li JY
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan Province, 610041, People's Republic of China.
FAU - Lu, Zhong-Jiao
AU  - Lu ZJ
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan Province, 610041, People's Republic of China.
FAU - Suo, Xue-Ling
AU  - Suo XL
AD  - Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, 
      Sichuan University, Chengdu, People's Republic of China.
FAU - Li, Nan-Nan
AU  - Li NN
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan Province, 610041, People's Republic of China.
FAU - Lei, Du
AU  - Lei D
AD  - Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, 
      Sichuan University, Chengdu, People's Republic of China.
FAU - Wang, Ling
AU  - Wang L
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan Province, 610041, People's Republic of China.
FAU - Peng, Jia-Xin
AU  - Peng JX
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan Province, 610041, People's Republic of China.
FAU - Duan, Li-Ren
AU  - Duan LR
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan Province, 610041, People's Republic of China.
FAU - Xi, Jing
AU  - Xi J
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan Province, 610041, People's Republic of China.
FAU - Jiang, Yi
AU  - Jiang Y
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan Province, 610041, People's Republic of China.
FAU - Gong, Qi-Yong
AU  - Gong QY
AD  - Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, 
      Sichuan University, Chengdu, People's Republic of China.
FAU - Peng, Rong
AU  - Peng R
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan Province, 610041, People's Republic of China. qrongpeng@126.com.
LA  - eng
GR  - 2018HH0077/Sichuan Science and Technology Program/
GR  - 2018FZ0029/Sichuan Science and Technology Program/
GR  - 2018SCU12029/The Fundamental Research Funds for the Central Universities/
GR  - 81801272/National Natural Science Foundation of China/
GR  - 2017M610605/China Postdoctoral Science Foundation/
GR  - 2018HXBH085/Post-Doctor Research Project, West China Hospital, Sichuan 
      University/
PT  - Journal Article
PL  - United States
TA  - Brain Imaging Behav
JT  - Brain imaging and behavior
JID - 101300405
SB  - IM
MH  - Brain/diagnostic imaging
MH  - *Essential Tremor/diagnostic imaging
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - *Parkinson Disease/diagnostic imaging
MH  - Tremor/diagnostic imaging
OTO - NOTNLM
OT  - Essential tremor
OT  - Parkinson's disease
OT  - Regional homogeneity
OT  - Rest tremor
OT  - rs-fMRI
EDAT- 2020/01/29 06:00
MHDA- 2021/03/23 06:00
CRDT- 2020/01/29 06:00
PHST- 2020/01/29 06:00 [pubmed]
PHST- 2021/03/23 06:00 [medline]
PHST- 2020/01/29 06:00 [entrez]
AID - 10.1007/s11682-019-00214-4 [pii]
AID - 10.1007/s11682-019-00214-4 [doi]
PST - ppublish
SO  - Brain Imaging Behav. 2020 Dec;14(6):2606-2617. doi: 10.1007/s11682-019-00214-4.