PMID- 31989486 OWN - NLM STAT- MEDLINE DCOM- 20201015 LR - 20210401 IS - 1865-8652 (Electronic) IS - 0741-238X (Print) IS - 0741-238X (Linking) VI - 37 IP - 3 DP - 2020 Mar TI - Sulodexide for the Symptoms and Signs of Chronic Venous Disease: A Systematic Review and Meta-analysis. PG - 1013-1033 LID - 10.1007/s12325-020-01232-1 [doi] AB - INTRODUCTION: Chronic venous disease (CVD) is a common condition associated with valvular dysfunction, venous hypertension and endothelial inflammation. Sulodexide facilitates the healing of venous ulcers and is frequently used in patients with CVD without ulcer. This review assessed the efficacy and safety of sulodexide for treatment of signs and symptoms of lower extremity CVD. METHODS: We searched MEDLINE, EMBASE, CINAHL and AMED as well as the Cochrane Central Register of Controlled Trials and the World Health Organisation (WHO) International Clinical Trials Registry Platform Search Portal. We also manually searched potentially relevant journals, conference proceedings and journal supplements. Any study monitoring any effect of sulodexide in patients with CVD at any stage of the disease, classified or non-classified, was considered. Treatment effects were estimated using standardised mean differences (SMDs), mean differences (MDs) and risk ratios (RRs), as appropriate. We calculated 95% confidence intervals (CIs) and heterogeneity (Q, tau and I(2)). RESULTS: The search found 64 studies, but only 23 provided data on 7153 participants (mean age 55 years; 68% female). The 13 studies providing extractable quantitative information included 1901 participants (mean age 55.2 years; 65% female). Sulodexide decreased the intensity of pain, cramps, heaviness, oedema and total symptom score and reduced inflammatory mediators in patients with CVD. The risk of adverse events (AEs) was not different between sulodexide and placebo or heparan sulphate (RR 1.31, 95% CI 0.74-2.32; I(2) = 0%; 270 participants). The overall risk of AEs with sulodexide was low: 3% (95% CI 1-4%) estimated from 3656 participants. CONCLUSION: Sulodexide was found to have a beneficial venoactive effect on the major signs and symptoms of CVD such as pain, cramps, heaviness and oedema without increasing the risk of AEs. It is also likely to exert a systemic effect on the course of CVD by interfering with inflammatory chemokines. FAU - Bignamini, Angelo A AU - Bignamini AA AD - Department of Pharmaceutical Sciences, School of Specialisation in Hospital Pharmacy, University of Milan, Milano, Italy. angelo@aabignamini.it. FAU - Matuska, Jiri AU - Matuska J AD - Angiologicka Ambulance, Hodonin, Czech Republic. LA - eng SI - figshare/10.6084/m9.figshare.11590920 PT - Journal Article PT - Meta-Analysis PT - Research Support, Non-U.S. Gov't PT - Systematic Review DEP - 20200127 PL - United States TA - Adv Ther JT - Advances in therapy JID - 8611864 RN - 0 (Anticoagulants) RN - 0 (Glycosaminoglycans) RN - 0 (Inflammation Mediators) RN - 75HGV0062C (glucuronyl glucosamine glycan sulfate) MH - Adult MH - Anticoagulants/administration & dosage/adverse effects MH - Chronic Disease MH - Female MH - Glycosaminoglycans/administration & dosage/adverse effects/*therapeutic use MH - Humans MH - Inflammation Mediators/metabolism MH - Lower Extremity/*pathology MH - Male MH - Middle Aged MH - Pain Measurement MH - Venous Insufficiency/*drug therapy PMC - PMC7089759 OTO - NOTNLM OT - Chronic venous disease OT - Efficacy OT - Meta-analysis OT - Safety OT - Sulodexide EDAT- 2020/01/29 06:00 MHDA- 2020/10/21 06:00 PMCR- 2020/01/27 CRDT- 2020/01/29 06:00 PHST- 2019/12/20 00:00 [received] PHST- 2020/01/29 06:00 [pubmed] PHST- 2020/10/21 06:00 [medline] PHST- 2020/01/29 06:00 [entrez] PHST- 2020/01/27 00:00 [pmc-release] AID - 10.1007/s12325-020-01232-1 [pii] AID - 1232 [pii] AID - 10.1007/s12325-020-01232-1 [doi] PST - ppublish SO - Adv Ther. 2020 Mar;37(3):1013-1033. doi: 10.1007/s12325-020-01232-1. Epub 2020 Jan 27.