PMID- 31991067
OWN - NLM
STAT- MEDLINE
DCOM- 20210621
LR  - 20210621
IS  - 2055-5822 (Electronic)
IS  - 2055-5822 (Linking)
VI  - 7
IP  - 2
DP  - 2020 Apr
TI  - Association between heart failure aetiology and magnitude of echocardiographic 
      remodelling and outcome of cardiac resynchronization therapy.
PG  - 645-653
LID - 10.1002/ehf2.12624 [doi]
AB  - AIMS: Echocardiographic response after cardiac resynchronization therapy (CRT) is 
      often lesser in ischaemic cardiomyopathy (ICM) than non-ischaemic dilated 
      cardiomyopathy (NIDCM) patients. We assessed the association of heart failure 
      aetiology on the amount of reverse remodelling and outcome of CRT. METHODS AND 
      RESULTS: Nine hundred twenty-eight CRT patients were retrospectively included. 
      Reverse remodelling and endpoint occurrence (all-cause mortality, heart 
      transplantation, or left ventricular assist device implantation) was assessed. 
      Two response definitions [>/=15% reduction left ventricular end systolic volume 
      (LVESV) and >/=5% improvement left ventricular ejection fraction] and the most 
      accurate cut-off for the amount of reverse remodelling that predicted endpoint 
      freedom were assessed. Mean follow-up was 3.8 +/- 2.4 years. ICM was present in 
      47%. ICM patients who were older (69 +/- 7 vs. 63 +/- 11), more often men (83% vs. 
      58%), exhibited less LVESV reduction (13 +/- 31% vs. 23 +/- 32%) and less left 
      ventricular ejection fraction improvement (5 +/- 11% vs. 10 +/- 12%) than NIDCM 
      patients (all P < 0.001). Nevertheless, every 1% LVESV reduction was associated 
      with a relative reduction in endpoint occurrence: NIDCM 1.3%, ICM 0.9%, and 
      absolute risk reduction was similar (0.4%). The most accurate cut-off of LVESV 
      reduction that predicted endpoint freedom was 17.1% in NIDCM and 13.2% in ICM. 
      CONCLUSIONS: ICM patients achieve less reverse remodelling than NIDCM, but the 
      prognostic gain in terms of survival time is the same for every single percentage 
      of reverse remodelling that does occur. The assessment and expected magnitude of 
      reverse remodelling should take this effect of heart failure aetiology into 
      account.
CI  - (c) 2020 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on 
      behalf of the European Society of Cardiology.
FAU - Kloosterman, Marielle
AU  - Kloosterman M
AD  - Department of Cardiology, University of Groningen, University Medical Centre 
      Groningen, PO Box 30.001, Groningen, 9700, RB, The Netherlands.
FAU - van Stipdonk, Antonius M W
AU  - van Stipdonk AMW
AD  - Department of Cardiology, Maastricht University Medical Center, Maastricht, the 
      Netherlands.
FAU - Ter Horst, Iris
AU  - Ter Horst I
AD  - Department of Cardiology, University Medical Center Utrecht, Utrecht, the 
      Netherlands.
FAU - Rienstra, Michiel
AU  - Rienstra M
AD  - Department of Cardiology, University of Groningen, University Medical Centre 
      Groningen, PO Box 30.001, Groningen, 9700, RB, The Netherlands.
FAU - Van Gelder, Isabelle C
AU  - Van Gelder IC
AD  - Department of Cardiology, University of Groningen, University Medical Centre 
      Groningen, PO Box 30.001, Groningen, 9700, RB, The Netherlands.
FAU - Vos, Marc A
AU  - Vos MA
AD  - Department of Medical Physiology, University Medical Center Utrecht, Utrecht, the 
      Netherlands.
FAU - Prinzen, Frits W
AU  - Prinzen FW
AD  - Department of Physiology, Cardiovascular Research Institute Maastricht (CARIM), 
      University of Maastricht, Maastricht, the Netherlands.
FAU - Meine, Matthias
AU  - Meine M
AD  - Department of Cardiology, University Medical Center Utrecht, Utrecht, the 
      Netherlands.
FAU - Vernooy, Kevin
AU  - Vernooy K
AD  - Department of Cardiology, Maastricht University Medical Center, Maastricht, the 
      Netherlands.
AD  - Department of Physiology, Cardiovascular Research Institute Maastricht (CARIM), 
      University of Maastricht, Maastricht, the Netherlands.
FAU - Maass, Alexander H
AU  - Maass AH
AD  - Department of Cardiology, University of Groningen, University Medical Centre 
      Groningen, PO Box 30.001, Groningen, 9700, RB, The Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20200128
PL  - England
TA  - ESC Heart Fail
JT  - ESC heart failure
JID - 101669191
SB  - IM
MH  - *Cardiac Resynchronization Therapy
MH  - Echocardiography
MH  - *Heart Failure/etiology/therapy
MH  - Humans
MH  - Male
MH  - Retrospective Studies
MH  - Stroke Volume
MH  - Treatment Outcome
MH  - Ventricular Function, Left
MH  - Ventricular Remodeling
PMC - PMC7160473
OTO - NOTNLM
OT  - Aetiology
OT  - Cardiac resynchronization therapy
OT  - Clinical response
OT  - Echocardiography
COIS- AHM reports lecture fees from Medtronic and LivaNova. The other authors have 
      nothing to disclose.
EDAT- 2020/01/29 06:00
MHDA- 2021/06/22 06:00
PMCR- 2020/01/28
CRDT- 2020/01/29 06:00
PHST- 2019/02/28 00:00 [received]
PHST- 2019/12/23 00:00 [revised]
PHST- 2020/01/03 00:00 [accepted]
PHST- 2020/01/29 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/01/29 06:00 [entrez]
PHST- 2020/01/28 00:00 [pmc-release]
AID - EHF212624 [pii]
AID - 10.1002/ehf2.12624 [doi]
PST - ppublish
SO  - ESC Heart Fail. 2020 Apr;7(2):645-653. doi: 10.1002/ehf2.12624. Epub 2020 Jan 28.