PMID- 31994228
OWN - NLM
STAT- MEDLINE
DCOM- 20210125
LR  - 20210125
IS  - 1873-474X (Electronic)
IS  - 0736-5748 (Linking)
VI  - 80
IP  - 2
DP  - 2020 Apr
TI  - Maternal lithium chloride exposure alters the neuroendocrine-cytokine axis in 
      neonatal albino rats.
PG  - 123-138
LID - 10.1002/jdn.10010 [doi]
AB  - The aim of this work was to clarify whether maternal lithium chloride (LiCl) 
      exposure disrupts the neonatal neuroendocrine-cytokine axis. Pregnant Wistar rats 
      were orally administrated 50 mg LiCl/kg b.wt. from gestational day (GD) 1 to 
      postpartum day 28. Maternal administration of LiCl induced a hypothyroid state in 
      both dams and their neonates compared to the control dams and neonates at 
      lactation days (LDs) 14, 21 and 28, where the levels of serum free 
      triiodothyronine (FT3) and free thyroxin (FT4) were decreased and the level of 
      serum thyrotropin (TSH) level was increased. A noticeable depression in maternal 
      body weight gain, neonatal body weight and neonatal serum growth hormone (GH) was 
      observed on all examined postnatal days (PNDs; 14, 21 and 28). A single abortion 
      case was recorded at GD 17, and three dead neonates were noted at birth in the 
      LiCl-treated group. Maternal administration of LiCl disturbed the levels of 
      neonatal serum tumor necrosis factor-alpha (TNF-alpha), transforming growth 
      factor-beta (TGF-beta), interleukin-1 beta (IL-1beta), interferon-gamma (INF-gamma), 
      leptin, adiponectin and resistin at all tested PNDs compared to the control 
      group. This administration produced a stimulatory action on the level of neonatal 
      cerebral serotonin (5-HT) at PND 14 and on the level of neonatal cerebral 
      norepinephrine (NE) at PNDs 21 and 28. However, this administration produced an 
      inhibitory action on the level of neonatal cerebral dopamine (DA) at all examined 
      PNDs and on the level of neonatal cerebral NE at PND 14 and the level of neonatal 
      cerebral 5-HT at PNDs 21 and 28 compared to the corresponding control group. 
      Thus, maternal LiCl exposure-induced hypothyroidism disrupts the neonatal 
      neuroendocrine-cytokine system, which delay cerebral development.
CI  - (c) 2020 ISDN. Published by John Wiley & Sons Ltd.
FAU - Mohammed, Dena A-E
AU  - Mohammed DA
AUID- ORCID: 0000-0001-6839-0381
AD  - Division of Anatomy and Embryology, Zoology Department, Faculty of Science, 
      Beni-Suef University, Beni-Suef, Egypt.
FAU - Ahmed, Rasha R
AU  - Ahmed RR
AUID- ORCID: 0000-0002-7640-9625
AD  - Division of Histology and Cytology, Zoology Department, Faculty of Science, 
      Beni-Suef University, Beni-Suef, Egypt.
FAU - Ahmed, R G
AU  - Ahmed RG
AUID- ORCID: 0000-0001-5644-8291
AD  - Division of Anatomy and Embryology, Zoology Department, Faculty of Science, 
      Beni-Suef University, Beni-Suef, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20200306
PL  - United States
TA  - Int J Dev Neurosci
JT  - International journal of developmental neuroscience : the official journal of the 
      International Society for Developmental Neuroscience
JID - 8401784
RN  - 0 (Antimanic Agents)
RN  - 0 (Biogenic Monoamines)
RN  - 0 (Cytokines)
RN  - 06LU7C9H1V (Triiodothyronine)
RN  - 9002-71-5 (Thyrotropin)
RN  - 9002-72-6 (Growth Hormone)
RN  - G4962QA067 (Lithium Chloride)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Antimanic Agents/*pharmacology
MH  - Biogenic Monoamines/metabolism
MH  - Body Weight/drug effects
MH  - Brain Chemistry/drug effects
MH  - Cytokines/*metabolism
MH  - Female
MH  - Growth Hormone/blood
MH  - Hypothyroidism/chemically induced/metabolism
MH  - Lithium Chloride/*pharmacology
MH  - Maternal Exposure
MH  - Neurosecretory Systems/*drug effects
MH  - Pregnancy
MH  - Rats
MH  - Rats, Wistar
MH  - Thyrotropin/blood
MH  - Thyroxine/blood
MH  - Triiodothyronine/blood
OTO - NOTNLM
OT  - cytokine
OT  - dams
OT  - lithium chloride
OT  - monoamine
OT  - pups
OT  - thyroid
EDAT- 2020/01/30 06:00
MHDA- 2021/01/26 06:00
CRDT- 2020/01/30 06:00
PHST- 2019/12/20 00:00 [received]
PHST- 2020/01/16 00:00 [revised]
PHST- 2020/01/20 00:00 [accepted]
PHST- 2020/01/30 06:00 [pubmed]
PHST- 2021/01/26 06:00 [medline]
PHST- 2020/01/30 06:00 [entrez]
AID - 10.1002/jdn.10010 [doi]
PST - ppublish
SO  - Int J Dev Neurosci. 2020 Apr;80(2):123-138. doi: 10.1002/jdn.10010. Epub 2020 Mar 
      6.