PMID- 31997038
OWN - NLM
STAT- MEDLINE
DCOM- 20210208
LR  - 20210212
IS  - 1432-1459 (Electronic)
IS  - 0340-5354 (Print)
IS  - 0340-5354 (Linking)
VI  - 267
IP  - 5
DP  - 2020 May
TI  - Sporadic inclusion body myositis: no specific cardiac involvement in cardiac 
      magnetic resonance tomography.
PG  - 1407-1413
LID - 10.1007/s00415-020-09724-4 [doi]
AB  - OBJECTIVE: To investigate cardiac involvement in patients with sporadic inclusion 
      body myositis (IBM) by cardiac magnetic resonance tomography (CMR). METHODS: A 
      case series of 20 patients with IBM underwent basic cardiac assessment and CMR 
      including functional imaging, native and contrast-enhanced T1-weighted, and late 
      gadolinium enhancement (LGE) imaging. RESULTS: All IBM patients reported no 
      cardiac symptoms. Echocardiography was normal in 16/17 IBM patients. In CMR, IBM 
      patients had normal ejection fractions (mean LVEF 63 +/- 7%) and ventricular mass. 
      They had reduced left (mean 55 versus 88 ml) and right ventricular stroke volumes 
      (mean 54 versus 86 ml) and increased early myocardial enhancement (pathological 
      T1 Ratio in 44% versus 5%), as compared to age- and gender-matched controls. 
      Since arterial hypertension was more often observed in IBM patients, hypertensive 
      heart disease can also be causative for these changes. Late gadolinium 
      enhancement did not differ statistically from healthy controls. There was no 
      apparent association between elevated biomarkers, echocardiography and CMR. 
      CONCLUSION: CMR revealed subtle changes in cardiac geometry and tissue 
      characterization in IBM patients when compared to a gender- and age-matched 
      control group. Findings in CMR indicated a higher extent of diffuse myocardial 
      fibrosis as well as smaller left ventricular stroke volumes. These alterations 
      may be due to a higher prevalence of arterial hypertension in the IBM cohort.
FAU - Rosenbohm, Angela
AU  - Rosenbohm A
AUID- ORCID: 0000-0001-9700-0338
AD  - Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, 
      Germany. angela.rosenbohm@uni-ulm.de.
FAU - Buckert, Dominik
AU  - Buckert D
AD  - Department of Internal Medicine II, University of Ulm, Ulm, Germany.
FAU - Kassubek, Jan
AU  - Kassubek J
AD  - Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, 
      Germany.
FAU - Rottbauer, Wolfgang
AU  - Rottbauer W
AD  - Department of Internal Medicine II, University of Ulm, Ulm, Germany.
FAU - Ludolph, Albert C
AU  - Ludolph AC
AD  - Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, 
      Germany.
FAU - Bernhardt, Peter
AU  - Bernhardt P
AD  - Heart Clinic Ulm, Ulm, Germany.
LA  - eng
PT  - Journal Article
DEP - 20200129
PL  - Germany
TA  - J Neurol
JT  - Journal of neurology
JID - 0423161
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Echocardiography
MH  - Female
MH  - Heart Diseases/*diagnostic imaging/*etiology
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Myositis, Inclusion Body/*complications
PMC - PMC7184047
OTO - NOTNLM
OT  - Cardiac magnetic resonance tomography
OT  - Inclusion body myositis
OT  - Late gadolinium enhancement
OT  - Myocarditis
COIS- On behalf of all authors, the corresponding author states that there is no 
      conflict of interest.
EDAT- 2020/01/31 06:00
MHDA- 2021/02/09 06:00
PMCR- 2020/01/29
CRDT- 2020/01/31 06:00
PHST- 2019/11/12 00:00 [received]
PHST- 2020/01/21 00:00 [accepted]
PHST- 2020/01/19 00:00 [revised]
PHST- 2020/01/31 06:00 [pubmed]
PHST- 2021/02/09 06:00 [medline]
PHST- 2020/01/31 06:00 [entrez]
PHST- 2020/01/29 00:00 [pmc-release]
AID - 10.1007/s00415-020-09724-4 [pii]
AID - 9724 [pii]
AID - 10.1007/s00415-020-09724-4 [doi]
PST - ppublish
SO  - J Neurol. 2020 May;267(5):1407-1413. doi: 10.1007/s00415-020-09724-4. Epub 2020 
      Jan 29.