PMID- 31997998
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220412
IS  - 1642-395X (Print)
IS  - 2299-0046 (Electronic)
IS  - 1642-395X (Linking)
VI  - 36
IP  - 6
DP  - 2019 Dec
TI  - Rationale for the autologous serum skin test in acute versus chronic urticaria.
PG  - 703-706
LID - 10.5114/ada.2019.91421 [doi]
AB  - INTRODUCTION: Autologous serum skin test (ASST) is a rapid, in-vivo clinical test 
      to detect functional autoantibodies in patients with chronic spontaneous 
      urticaria (CSU), but the rationale for its use in acute urticaria (AU) is 
      unknown. AIM: To evaluate the efficacy of ASST among patients with AU or CSU. 
      MATERIAL AND METHODS: Treatment-naive adult (age >/= 18 years) patients with a 
      diagnosis of AU (< 6 weeks' duration) and CSU were enrolled prospectively in a 
      cross-sectional study. Healthy age- and sex-matched subjects served as controls. 
      Besides a detailed history and physical examination, ASST, total immunoglobulin E 
      (IgE), freeT3 (fT3), freeT4 (fT4), anti-thyroglobulin, and anti-TPO levels were 
      assessed in all subjects. RESULTS: Of 101 subjects, mean age was 34.35 +/-12.68 
      years and the study comprised 58.4% of females with no difference between AU (n = 
      27), CSU (n = 46), and control groups (n = 28). The ratio of positivity in ASST 
      was similar between AU (25.9%) and CSU groups (21.7%), but higher than in 
      controls (10.7%, p = 0.33 for all). The ratio of patients with high total IgE 
      levels (> 100 IU/ml) in AU (85.2%) and CSU (65.2%) groups was similar (p = 0.06), 
      but significantly higher than in the control group (10.7%) (p< 0.001 and p< 
      0.001). The CSU group had significantly higher abnormal thyroid test results 
      (45.7%) than AU (14.8%) and control groups (3.6%) (p = 0.01 and p< 0.001), 
      whereas patients with clinically diagnosed thyroiditis were only in the CSU group 
      (6.5%). In logistic regression analysis, there was no relation found among the 
      possible risk factors for ASST, even if analysed separately as AU, CSU and 
      control groups. CONCLUSIONS: Even though thyroid function test levels were found 
      to be related with CSU, and total IgE was associated with urticaria, ASST was 
      found to be of importance. This study confirms that ASST was insufficient to 
      demonstrate autoimmunity and acute-chronic urticaria nature. Further tests 
      indicating auto-antibodies in AU and CSU are needed.
CI  - Copyright (c) 2019 Termedia.
FAU - Demirkan, Serkan
AU  - Demirkan S
AD  - Department of Dermatology and Venerology, Faculty of Medicine, Kirikkale 
      University, Kirikkale, Turkey.
FAU - Baccioglu, Ayse
AU  - Baccioglu A
AD  - Department of Pulmonary Diseases, Division of Immunology and Allergy, Faculty of 
      Medicine, Kirikkale University, Kirikkale, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20191230
PL  - Poland
TA  - Postepy Dermatol Alergol
JT  - Postepy dermatologii i alergologii
JID - 101168357
PMC - PMC6986284
OTO - NOTNLM
OT  - autoimmunity
OT  - autologous serum skin test
OT  - chronic urticaria
COIS- The authors declare no conflict of interest.
EDAT- 2020/01/31 06:00
MHDA- 2020/01/31 06:01
PMCR- 2019/12/01
CRDT- 2020/01/31 06:00
PHST- 2018/01/16 00:00 [received]
PHST- 2018/07/11 00:00 [accepted]
PHST- 2020/01/31 06:00 [entrez]
PHST- 2020/01/31 06:00 [pubmed]
PHST- 2020/01/31 06:01 [medline]
PHST- 2019/12/01 00:00 [pmc-release]
AID - 91421 [pii]
AID - 10.5114/ada.2019.91421 [doi]
PST - ppublish
SO  - Postepy Dermatol Alergol. 2019 Dec;36(6):703-706. doi: 10.5114/ada.2019.91421. 
      Epub 2019 Dec 30.