PMID- 31998445
OWN - NLM
STAT- MEDLINE
DCOM- 20200603
LR  - 20211214
IS  - 1942-0994 (Electronic)
IS  - 1942-0900 (Print)
IS  - 1942-0994 (Linking)
VI  - 2020
DP  - 2020
TI  - Inhibition of Mitochondrial ROS by MitoQ Alleviates White Matter Injury and 
      Improves Outcomes after Intracerebral Haemorrhage in Mice.
PG  - 8285065
LID - 10.1155/2020/8285065 [doi]
LID - 8285065
AB  - White matter injury (WMI) is an important cause of high disability after 
      intracerebral haemorrhage (ICH). It is widely accepted that reactive oxygen 
      species (ROS) contributes to WMI, but there is still no evidence-based treatment. 
      Here, mitoquinone (MitoQ), a newly developed selective mitochondrial ROS 
      scavenger, was used to test its neuroprotective potential. The data showed that 
      MitoQ attenuated motor function deficits and motor-evoked potential (MEP) latency 
      prolongation. Further research found that MitoQ blunted the loss of 
      oligodendrocytes and oligodendrocyte precursor cells, therefore reduced 
      demyelination and axon swelling after ICH. In the in vitro experiments, MitoQ, 
      but not the nonselective antioxidant, almost completely attenuated the 
      iron-induced membrane potential decrease and cell death. Mechanistically, MitoQ 
      blocked the ATP deletion and mitochondrial ROS overproduction. The present study 
      demonstrates that the selective mitochondrial ROS scavenger MitoQ may improve the 
      efficacy of antioxidant treatment of ICH by white matter injury alleviation.
CI  - Copyright (c) 2020 Weixiang Chen et al.
FAU - Chen, Weixiang
AU  - Chen W
AD  - Department of Neurosurgery, Southwest Hospital, Third Military Medical University 
      (Army Medical University), 29 Gaotanyan Street, Shapingba District, Chongqing 
      400038, China.
FAU - Guo, Chao
AU  - Guo C
AD  - Department of Neurosurgery, Southwest Hospital, Third Military Medical University 
      (Army Medical University), 29 Gaotanyan Street, Shapingba District, Chongqing 
      400038, China.
FAU - Jia, Zhengcai
AU  - Jia Z
AD  - Department of Neurosurgery, Southwest Hospital, Third Military Medical University 
      (Army Medical University), 29 Gaotanyan Street, Shapingba District, Chongqing 
      400038, China.
FAU - Wang, Jie
AU  - Wang J
AD  - Department of Neurosurgery, Southwest Hospital, Third Military Medical University 
      (Army Medical University), 29 Gaotanyan Street, Shapingba District, Chongqing 
      400038, China.
FAU - Xia, Min
AU  - Xia M
AD  - Department of Neurosurgery, Southwest Hospital, Third Military Medical University 
      (Army Medical University), 29 Gaotanyan Street, Shapingba District, Chongqing 
      400038, China.
FAU - Li, Chengcheng
AU  - Li C
AD  - Department of Neurosurgery, Southwest Hospital, Third Military Medical University 
      (Army Medical University), 29 Gaotanyan Street, Shapingba District, Chongqing 
      400038, China.
FAU - Li, Mingxi
AU  - Li M
AD  - Department of Neurosurgery, Southwest Hospital, Third Military Medical University 
      (Army Medical University), 29 Gaotanyan Street, Shapingba District, Chongqing 
      400038, China.
FAU - Yin, Yi
AU  - Yin Y
AD  - Department of Neurosurgery, Southwest Hospital, Third Military Medical University 
      (Army Medical University), 29 Gaotanyan Street, Shapingba District, Chongqing 
      400038, China.
FAU - Tang, Xiaoqin
AU  - Tang X
AD  - Department of Neurosurgery, Southwest Hospital, Third Military Medical University 
      (Army Medical University), 29 Gaotanyan Street, Shapingba District, Chongqing 
      400038, China.
FAU - Chen, Tunan
AU  - Chen T
AD  - Department of Neurosurgery, Southwest Hospital, Third Military Medical University 
      (Army Medical University), 29 Gaotanyan Street, Shapingba District, Chongqing 
      400038, China.
FAU - Hu, Rong
AU  - Hu R
AD  - Department of Neurosurgery, Southwest Hospital, Third Military Medical University 
      (Army Medical University), 29 Gaotanyan Street, Shapingba District, Chongqing 
      400038, China.
FAU - Chen, Yujie
AU  - Chen Y
AUID- ORCID: 0000-0002-9905-9138
AD  - Department of Neurosurgery, Southwest Hospital, Third Military Medical University 
      (Army Medical University), 29 Gaotanyan Street, Shapingba District, Chongqing 
      400038, China.
FAU - Liu, Xin
AU  - Liu X
AUID- ORCID: 0000-0003-0111-2429
AD  - Department of Neurosurgery, Southwest Hospital, Third Military Medical University 
      (Army Medical University), 29 Gaotanyan Street, Shapingba District, Chongqing 
      400038, China.
FAU - Feng, Hua
AU  - Feng H
AUID- ORCID: 0000-0003-4489-9217
AD  - Department of Neurosurgery, Southwest Hospital, Third Military Medical University 
      (Army Medical University), 29 Gaotanyan Street, Shapingba District, Chongqing 
      400038, China.
LA  - eng
PT  - Journal Article
DEP - 20200104
PL  - United States
TA  - Oxid Med Cell Longev
JT  - Oxidative medicine and cellular longevity
JID - 101479826
RN  - 0 (Organophosphorus Compounds)
RN  - 0 (Reactive Oxygen Species)
RN  - 1339-63-5 (Ubiquinone)
RN  - 47BYS17IY0 (mitoquinone)
SB  - IM
MH  - Animals
MH  - Cerebral Hemorrhage/*drug therapy/metabolism/pathology
MH  - Mice
MH  - Mitochondria/*metabolism/pathology
MH  - Organophosphorus Compounds/*pharmacology
MH  - Reactive Oxygen Species/*antagonists & inhibitors/metabolism
MH  - Ubiquinone/*analogs & derivatives/pharmacology
MH  - White Matter/*metabolism/pathology
PMC - PMC6969671
COIS- No relevant conflicts of interest.
EDAT- 2020/01/31 06:00
MHDA- 2020/06/04 06:00
PMCR- 2020/01/04
CRDT- 2020/01/31 06:00
PHST- 2019/08/16 00:00 [received]
PHST- 2019/10/02 00:00 [revised]
PHST- 2019/10/19 00:00 [accepted]
PHST- 2020/01/31 06:00 [entrez]
PHST- 2020/01/31 06:00 [pubmed]
PHST- 2020/06/04 06:00 [medline]
PHST- 2020/01/04 00:00 [pmc-release]
AID - 10.1155/2020/8285065 [doi]
PST - epublish
SO  - Oxid Med Cell Longev. 2020 Jan 4;2020:8285065. doi: 10.1155/2020/8285065. 
      eCollection 2020.