PMID- 31998744
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 2296-875X (Print)
IS  - 2296-875X (Electronic)
IS  - 2296-875X (Linking)
VI  - 6
DP  - 2019
TI  - Endoscopic Treatment of Idiopathic Subglottic Stenosis: A Systematic Review.
PG  - 75
LID - 10.3389/fsurg.2019.00075 [doi]
LID - 75
AB  - Purpose: To identify different endoscopic techniques for treatment of idiopathic 
      subglottic stenosis (iSGS) and evaluate treatment results. Methods: Embase and 
      Cochrane Library were searched for publications on endoscopically treated iSGS. 
      Identified interventions included procedures with cold knife, dilation (rigid or 
      balloon), or laser (CO(2) or Nd:YAG), used in several combinations and 
      supplemented with mitomycin C and/or corticosteroids. Primary endpoint was time 
      interval between successive endoscopic procedures. Secondary endpoints were 
      stenosis recurrence rate, total number of interventions per patient during 
      follow-up, tracheotomy rate, and rate of open surgery. Results: Eighty-six 
      abstracts were reviewed and 15 series were included in the analysis. Mean sample 
      size was 57 subjects (range 10-384, sigma 90.84) and mean age was 47 years (range 
      36-54, sigma 4.45). Time interval ranged from 2 to 21 months [weighted mean (WM): 
      12]. Rate of stenosis recurrence ranged from 40 to 100% (WM: 68%). Mean amount of 
      interventions per patient varied between 1.8 and 8.3 (WM: 3.7). Tracheotomy rate 
      varied between 0 and 26% (WM: 7%) and rate of open surgery varied between 0 and 
      27% (WM: 10%). Single modality CO(2) lasering showed highest rate of recurrence, 
      highest amount of interventions, and shortest time interval. Combined techniques 
      generated overall better outcomes. Conclusions: A multitude of endoscopic 
      techniques are being used for treating iSGS, all with a considerable recurrence 
      rate. In this review, no superior modality could be identified. Consequently, 
      endoscopic management could be considered a valuable primary treatment option for 
      iSGS, but open surgery still plays an important role.
CI  - Copyright (c) 2020 Lavrysen, Hens, Delaere and Meulemans.
FAU - Lavrysen, Emilie
AU  - Lavrysen E
AD  - Otorhinolaryngology-Head and Neck Surgery, University Hospital Leuven, Leuven, 
      Belgium.
FAU - Hens, Greet
AU  - Hens G
AD  - Otorhinolaryngology-Head and Neck Surgery, University Hospital Leuven, Leuven, 
      Belgium.
FAU - Delaere, Pierre
AU  - Delaere P
AD  - Otorhinolaryngology-Head and Neck Surgery, University Hospital Leuven, Leuven, 
      Belgium.
FAU - Meulemans, Jeroen
AU  - Meulemans J
AD  - Otorhinolaryngology-Head and Neck Surgery, University Hospital Leuven, Leuven, 
      Belgium.
LA  - eng
PT  - Systematic Review
DEP - 20200110
PL  - Switzerland
TA  - Front Surg
JT  - Frontiers in surgery
JID - 101645127
PMC - PMC6965146
OTO - NOTNLM
OT  - Nd:YAG laser
OT  - balloon dilation
OT  - carbon dioxide laser
OT  - idiopathic subglottic stenosis
OT  - laryngotracheal stenosis
OT  - mitomycin C
OT  - rigid dilation
EDAT- 2020/01/31 06:00
MHDA- 2020/01/31 06:01
PMCR- 2020/01/10
CRDT- 2020/01/31 06:00
PHST- 2019/11/04 00:00 [received]
PHST- 2019/12/13 00:00 [accepted]
PHST- 2020/01/31 06:00 [entrez]
PHST- 2020/01/31 06:00 [pubmed]
PHST- 2020/01/31 06:01 [medline]
PHST- 2020/01/10 00:00 [pmc-release]
AID - 10.3389/fsurg.2019.00075 [doi]
PST - epublish
SO  - Front Surg. 2020 Jan 10;6:75. doi: 10.3389/fsurg.2019.00075. eCollection 2019.