PMID- 31998781
OWN - NLM
STAT- MEDLINE
DCOM- 20200921
LR  - 20220412
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2020
DP  - 2020
TI  - Association of Hyperhomocysteinemia with Increased Coronary Microcirculatory 
      Resistance and Poor Short-Term Prognosis of Patients with Acute Myocardial 
      Infarction after Elective Percutaneous Coronary Intervention.
PG  - 1710452
LID - 10.1155/2020/1710452 [doi]
LID - 1710452
AB  - BACKGROUND: This study aims to investigate the coronary microcirculatory 
      resistance and prognosis of patients with acute myocardial infarction (AMI) 
      concomitant with hyperhomocysteinemia (HHcy) after an elective percutaneous 
      coronary intervention (PCI). METHODS: A total of 101 patients that underwent 
      elective PCI between May 2015 and July 2018 due to AMI were consecutively 
      enrolled in this study. Patients were divided into a HHcy group (53) and a normal 
      Hcy group (control; 48) based on their plasma homocysteine concentration. The 
      characteristics of coronary angiography, the index of microcirculatory resistance 
      (IMR) of infarct-related vessels (IRV), changes in left ventricular end diastolic 
      diameter (LVEDd) and left ventricular ejection fraction (LVEF) before and after 
      PCI, and the incidence of major adverse cardiovascular events (MACE) three months 
      after PCI were compared between these groups. RESULTS: Compared to the results 
      from the Hcy group, the HHcy group had a higher IMR. The HHcy group had 
      significantly higher LVEDd and a lower LVEF than the Hcy group 3 months after 
      PCI. Additionally, the incidence of MACE at three months after PCI was higher in 
      the HHcy group than in the Hcy group. Pearson correlation analysis revealed a 
      positive correlation with IMR in the HHcy group. Furthermore, there was a 
      difference in the LVEDd measured at one day after PCI and at three months after 
      PCI in the HHcy group. CONCLUSION: AMI patients concomitant with HHcy that 
      undergo elective PCI are prone to coronary microcirculatory dysfunction and have 
      a poor cardiac function and poor prognosis at three months after PCI.
CI  - Copyright (c) 2020 Yang-Pei Peng et al.
FAU - Peng, Yang-Pei
AU  - Peng YP
AUID- ORCID: 0000-0002-8122-3374
AD  - Department of Cardiology, The Second Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, Zhejiang 325000, China.
FAU - Huang, Ming-Yuan
AU  - Huang MY
AD  - Department of Cardiology, The Second Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, Zhejiang 325000, China.
FAU - Xue, Yang-Jing
AU  - Xue YJ
AUID- ORCID: 0000-0001-9041-4781
AD  - Department of Cardiology, The Second Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, Zhejiang 325000, China.
FAU - Pan, Jia-Lin
AU  - Pan JL
AUID- ORCID: 0000-0002-2701-4221
AD  - Department of Cardiology, The Second Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, Zhejiang 325000, China.
FAU - Lin, Cong
AU  - Lin C
AUID- ORCID: 0000-0002-1334-9047
AD  - Department of Cardiology, The Second Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, Zhejiang 325000, China.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20200102
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
SB  - IM
MH  - Aged
MH  - *Capillary Resistance
MH  - *Coronary Circulation
MH  - Elective Surgical Procedures/*adverse effects
MH  - Female
MH  - Humans
MH  - Hyperhomocysteinemia/blood/diagnosis/etiology/physiopathology
MH  - Male
MH  - Middle Aged
MH  - *Myocardial Infarction/blood/diagnosis/surgery
MH  - Percutaneous Coronary Intervention/*adverse effects
MH  - *Postoperative Complications/blood/diagnosis/physiopathology
MH  - Prognosis
MH  - Time Factors
PMC - PMC6970506
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2020/01/31 06:00
MHDA- 2020/09/22 06:00
PMCR- 2020/01/02
CRDT- 2020/01/31 06:00
PHST- 2019/11/02 00:00 [received]
PHST- 2019/12/09 00:00 [accepted]
PHST- 2020/01/31 06:00 [entrez]
PHST- 2020/01/31 06:00 [pubmed]
PHST- 2020/09/22 06:00 [medline]
PHST- 2020/01/02 00:00 [pmc-release]
AID - 10.1155/2020/1710452 [doi]
PST - epublish
SO  - Biomed Res Int. 2020 Jan 2;2020:1710452. doi: 10.1155/2020/1710452. eCollection 
      2020.