PMID- 32003746
OWN - NLM
STAT- MEDLINE
DCOM- 20210414
LR  - 20210414
IS  - 2050-084X (Electronic)
IS  - 2050-084X (Linking)
VI  - 9
DP  - 2020 Jan 31
TI  - A cis-carotene derived apocarotenoid regulates etioplast and chloroplast 
      development.
LID - 10.7554/eLife.45310 [doi]
LID - e45310
AB  - Carotenoids are a core plastid component and yet their regulatory function during 
      plastid biogenesis remains enigmatic. A unique carotenoid biosynthesis mutant, 
      carotenoid chloroplast regulation 2 (ccr2), that has no prolamellar body (PLB) 
      and normal PROTOCHLOROPHYLLIDE OXIDOREDUCTASE (POR) levels, was used to 
      demonstrate a regulatory function for carotenoids and their derivatives under 
      varied dark-light regimes. A forward genetics approach revealed how an epistatic 
      interaction between a zeta-carotene isomerase mutant (ziso-155) and ccr2 blocked the 
      biosynthesis of specific cis-carotenes and restored PLB formation in etioplasts. 
      We attributed this to a novel apocarotenoid retrograde signal, as chemical 
      inhibition of carotenoid cleavage dioxygenase activity restored PLB formation in 
      ccr2 etioplasts during skotomorphogenesis. The apocarotenoid acted in parallel to 
      the repressor of photomorphogenesis, DEETIOLATED1 (DET1), to transcriptionally 
      regulate PROTOCHLOROPHYLLIDE OXIDOREDUCTASE (POR), PHYTOCHROME INTERACTING 
      FACTOR3 (PIF3) and ELONGATED HYPOCOTYL5 (HY5). The unknown apocarotenoid signal 
      restored POR protein levels and PLB formation in det1, thereby controlling 
      plastid development.
CI  - (c) 2020, Cazzonelli et al.
FAU - Cazzonelli, Christopher I
AU  - Cazzonelli CI
AUID- ORCID: 0000-0003-3096-3193
AD  - Hawkesbury Institute for the Environment, Western Sydney University, Penrith, 
      Australia.
FAU - Hou, Xin
AU  - Hou X
AUID- ORCID: 0000-0003-4625-1692
AD  - Research School of Biology, The Australian National University, Canberra, 
      Australia.
FAU - Alagoz, Yagiz
AU  - Alagoz Y
AUID- ORCID: 0000-0001-5081-6874
AD  - Hawkesbury Institute for the Environment, Western Sydney University, Penrith, 
      Australia.
FAU - Rivers, John
AU  - Rivers J
AUID- ORCID: 0000-0002-7500-5637
AD  - Research School of Biology, The Australian National University, Canberra, 
      Australia.
FAU - Dhami, Namraj
AU  - Dhami N
AUID- ORCID: 0000-0002-6014-3500
AD  - Hawkesbury Institute for the Environment, Western Sydney University, Penrith, 
      Australia.
FAU - Lee, Jiwon
AU  - Lee J
AD  - Centre for Advanced Microscopy, The Australian National University, Canberra, 
      Australia.
FAU - Marri, Shashikanth
AU  - Marri S
AD  - Research School of Biology, The Australian National University, Canberra, 
      Australia.
FAU - Pogson, Barry J
AU  - Pogson BJ
AUID- ORCID: 0000-0003-1869-2423
AD  - Research School of Biology, The Australian National University, Canberra, 
      Australia.
LA  - eng
SI  - SRA/PRJNA498324
GR  - CE140100008/Centre of Excellence in Plant Energy Biology, Australian Research 
      Council/
GR  - DP130102593/Australian Research Council/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200131
PL  - England
TA  - Elife
JT  - eLife
JID - 101579614
RN  - 0 (Arabidopsis Proteins)
RN  - 36-88-4 (Carotenoids)
SB  - IM
MH  - Arabidopsis/genetics/growth & development/metabolism
MH  - Arabidopsis Proteins/genetics/metabolism
MH  - *Carotenoids/chemistry/metabolism
MH  - *Chloroplasts/genetics/metabolism/physiology
MH  - Gene Expression Regulation, Developmental
MH  - *Gene Expression Regulation, Plant
MH  - Photoperiod
MH  - Photosynthesis/genetics/physiology
MH  - Plant Leaves/growth & development/metabolism/physiology
PMC - PMC6994220
OTO - NOTNLM
OT  - A. thaliana
OT  - apocarotenoid signal
OT  - carotenoid
OT  - etioplast
OT  - plant biology
OT  - prolamellar body
OT  - retrograde signal
OT  - transcriptional regulation
COIS- CC, XH, YA, JR, ND, JL, SM, BP No competing interests declared
EDAT- 2020/02/01 06:00
MHDA- 2021/04/15 06:00
PMCR- 2020/01/31
CRDT- 2020/02/01 06:00
PHST- 2019/01/18 00:00 [received]
PHST- 2020/01/07 00:00 [accepted]
PHST- 2020/02/01 06:00 [entrez]
PHST- 2020/02/01 06:00 [pubmed]
PHST- 2021/04/15 06:00 [medline]
PHST- 2020/01/31 00:00 [pmc-release]
AID - 45310 [pii]
AID - 10.7554/eLife.45310 [doi]
PST - epublish
SO  - Elife. 2020 Jan 31;9:e45310. doi: 10.7554/eLife.45310.