PMID- 32004963
OWN - NLM
STAT- MEDLINE
DCOM- 20200626
LR  - 20231121
IS  - 1873-6424 (Electronic)
IS  - 0269-7491 (Print)
IS  - 0269-7491 (Linking)
VI  - 260
DP  - 2020 May
TI  - Serum concentrations of persistent organic pollutants and the metabolic syndrome 
      in Akwesasne Mohawks, a Native American community.
PG  - 114004
LID - S0269-7491(19)36041-5 [pii]
LID - 10.1016/j.envpol.2020.114004 [doi]
AB  - The metabolic syndrome (MetS) is a group of diseases that tend to occur together, 
      including diabetes, hypertension, central obesity, cardiovascular disease and 
      hyperlipidemia. Exposure to persistent organic pollutants (POPs) such as 
      polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) has been 
      associated with increased risk of development of several of the components of the 
      MetS. The goal of this study is to determine whether the associations with POPs 
      are identical for each of the components and for the MetS. The subject population 
      was 601 Native Americans (Akwesasne Mohawks) ages 18 to 84 who answered a 
      questionnaire, were measured for height and weight and provided blood samples for 
      clinical chemistries (serum lipids and fasting glucose) and analysis of 101 PCB 
      congeners and three OCPs [dichlorodiphenyldichloroethylene (DDE), 
      hexachlorobenzene (HCB) and mirex]. Associations between concentrations of total 
      PCBs and pesticides, as well as various PCB congener groups with each of the 
      different components of the MetS were determine so as to ask whether there were 
      similar risk factors for all components of the MetS. After adjustment for other 
      contaminants, diabetes and hypertension were strongly associated with lower 
      chlorinated and mono-ortho PCBs, but not other PCB groups or pesticides. Obesity 
      was most closely associated with highly chlorinated PCBs and was negatively 
      associated with mirex. High serum lipids were most strongly associated with 
      higher chlorinated PCBs and PCBs with multiple ortho-substituted chlorines, as 
      well as total pesticides, DDE and HCB. Cardiovascular disease was not closely 
      associated with levels of any of the measured POPs. While exposure to POPs is 
      associated with increased risk of most of the various diseases comprising the 
      MetS, the specific contaminants associated with risk of the component diseases 
      are not the same.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Aminov, Zafar
AU  - Aminov Z
AD  - Department of Environmental Health Sciences, School of Public Health, USA.
FAU - Carpenter, David O
AU  - Carpenter DO
AD  - Department of Environmental Health Sciences, School of Public Health, USA; 
      Institute for Health and the Environment, University at Albany, 5 University 
      Place, Rensselaer, NY, 12144, USA. Electronic address: dcarpenter@albany.edu.
LA  - eng
GR  - P42 ES004913/ES/NIEHS NIH HHS/United States
PT  - Journal Article
DEP - 20200123
PL  - England
TA  - Environ Pollut
JT  - Environmental pollution (Barking, Essex : 1987)
JID - 8804476
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Pesticides)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Environmental Exposure/*statistics & numerical data
MH  - Environmental Pollutants/*blood
MH  - Humans
MH  - Hydrocarbons, Chlorinated
MH  - Indians, North American/statistics & numerical data
MH  - Metabolic Syndrome/*epidemiology
MH  - Middle Aged
MH  - Pesticides
MH  - Polychlorinated Biphenyls
MH  - United States/ethnology
MH  - Young Adult
PMC - PMC10658355
MID - NIHMS1555386
OTO - NOTNLM
OT  - Diabetes
OT  - Hyperlipidemia
OT  - Hypertension
OT  - Native Americans
OT  - Obesity
COIS- Declaration of competing interest Both author declare that they do not have 
      conflicts of interest.
EDAT- 2020/02/01 06:00
MHDA- 2020/06/27 06:00
PMCR- 2023/11/20
CRDT- 2020/02/01 06:00
PHST- 2019/10/15 00:00 [received]
PHST- 2020/01/13 00:00 [revised]
PHST- 2020/01/15 00:00 [accepted]
PHST- 2020/02/01 06:00 [pubmed]
PHST- 2020/06/27 06:00 [medline]
PHST- 2020/02/01 06:00 [entrez]
PHST- 2023/11/20 00:00 [pmc-release]
AID - S0269-7491(19)36041-5 [pii]
AID - 10.1016/j.envpol.2020.114004 [doi]
PST - ppublish
SO  - Environ Pollut. 2020 May;260:114004. doi: 10.1016/j.envpol.2020.114004. Epub 2020 
      Jan 23.