PMID- 3200516
OWN - NLM
STAT- MEDLINE
DCOM- 19890119
LR  - 20141120
IS  - 0161-813X (Print)
IS  - 0161-813X (Linking)
VI  - 9
IP  - 3
DP  - 1988 Fall
TI  - Behavioral evaluation of rats prenatally exposed to the adrenergic agonists 
      clonidine and lofexidine.
PG  - 559-66
AB  - Clonidine (CLON), is a widely used antihypertensive agent with a potential for 
      expanded therapeutic application in combating drug withdrawal symptoms in opiate 
      and alcohol addiction. Recently, CLON and an analogue lofexidine (LOF) have been 
      shown to block the opiate withdrawal syndrome in a variety of species, including 
      man. One new application of these agents may be as an alternative to methadone 
      maintenance for pregnant opiate addicts. Any consideration along these lines will 
      require screening for reproductive outcome and behavioral teratogenic effects. 
      Dams were given s.c. injections of CLON (0.16 or 0.64 mg/kg) of LOF (0.64 or 2.56 
      mg/kg) once daily from gestational day (GD) 8-20. Neonatal body weights, at 
      postnatal days (PNDs) 2, 15 and 30 were reduced in a dose-dependent manner, with 
      LOF-induced reduction twice that of CLON. No significant differences were 
      obtained on negative geotaxis, an auditory startle test, or a series of swimming 
      immobilization tests across the periadolescent period. A series of activity 
      measures carried out on PND 12, 14, 16 and 18 showed minor differences in the 
      high dose LOF male animals, but not in any of the other drug-treated groups.
FAU - Pizzi, W J
AU  - Pizzi WJ
AD  - Department of Psychology, Northeastern Illinois University, Chicago 60625.
FAU - Ali, S F
AU  - Ali SF
FAU - Holson, R R
AU  - Holson RR
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Neurotoxicology
JT  - Neurotoxicology
JID - 7905589
RN  - 0 (Antihypertensive Agents)
RN  - MN3L5RMN02 (Clonidine)
RN  - UI82K0T627 (lofexidine)
SB  - IM
MH  - Animals
MH  - Antihypertensive Agents/*toxicity
MH  - Behavior, Animal/drug effects
MH  - Body Weight/drug effects
MH  - Clonidine/*analogs & derivatives/*toxicity
MH  - Drug Evaluation, Preclinical
MH  - Female
MH  - Male
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Reflex, Startle/drug effects
MH  - Swimming
EDAT- 1988/01/01 00:00
MHDA- 1988/01/01 00:01
CRDT- 1988/01/01 00:00
PHST- 1988/01/01 00:00 [pubmed]
PHST- 1988/01/01 00:01 [medline]
PHST- 1988/01/01 00:00 [entrez]
PST - ppublish
SO  - Neurotoxicology. 1988 Fall;9(3):559-66.