PMID- 32005306
OWN - NLM
STAT- MEDLINE
DCOM- 20210427
LR  - 20210602
IS  - 1815-7920 (Electronic)
IS  - 1027-3719 (Linking)
VI  - 24
IP  - 1
DP  - 2020 Jan 1
TI  - A novel approach for eliciting adolescent MDR-TB treatment tolerability: 
      qualitative data from South Africa.
PG  - 43-47
LID - 10.5588/ijtld.19.0207 [doi]
AB  - SETTING: Treatment tolerability among adolescents diagnosed with 
      multidrug-resistant tuberculosis (MDR-TB) is underexplored. We present 
      qualitative study data from adolescents participating in an observational cohort 
      in the Western Cape, South Africa.OBJECTIVE: To elicit adolescent experiences of 
      MDR-TB diagnosis and treatment with qualitative body-mapping activities and 
      discussions.DESIGN: Adolescents in an observational MDR-TB cohort received 
      routine toxicity and audiology screenings from clinicians. We enrolled eight 
      participants (age 10-16 years) to participate in additional body-mapping 
      activities and in-depth interviews. A thematic deductive analysis was conducted. 
      We present a comparison of the clinical assessments and qualitative 
      discussions.RESULTS: Adolescent participants reported few adverse effects on 
      standard toxicity and audiology reports. Only nausea and vomiting were reported 
      in >10% of cases, all of which were grade 1 (causing no/minimal interference) 
      adverse effects (AEs). However, when comparing toxicity reports with qualitative 
      body-mapping activities and interviews, we found previously unreported AEs 
      (neurosensory alteration, neuromuscular weakness, pain); underestimated severity 
      of AEs (nausea, itching); and missed psychosocial symptoms (signs of 
      depression).CONCLUSION: Adolescents receiving treatment for MDR-TB experienced 
      treatment-related AEs that were not reported during routine clinical assessments. 
      Psychosocial experiences of adolescents are not taken into account. More research 
      is needed to understand the experiences of this vulnerable group. We recommend 
      that drug safety monitoring be adapted to include more creative and 
      patient-driven reporting mechanisms for vulnerable groups, including children.
FAU - Zimri, K
AU  - Zimri K
AD  - Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of 
      Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.
FAU - Casper, R
AU  - Casper R
AD  - Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of 
      Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.
FAU - Hoddinott, G
AU  - Hoddinott G
AD  - Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of 
      Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.
FAU - Schaaf, H S
AU  - Schaaf HS
AD  - Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of 
      Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.
FAU - Garcia-Prats, A J
AU  - Garcia-Prats AJ
AD  - Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of 
      Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.
FAU - Rose, P C
AU  - Rose PC
AD  - Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of 
      Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.
FAU - Hesseling, A C
AU  - Hesseling AC
AD  - Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of 
      Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.
FAU - Viljoen, L
AU  - Viljoen L
AD  - Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of 
      Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.
LA  - eng
GR  - MR/M007340/1/MRC_/Medical Research Council/United Kingdom
GR  - R01 HD069169/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - France
TA  - Int J Tuberc Lung Dis
JT  - The international journal of tuberculosis and lung disease : the official journal 
      of the International Union against Tuberculosis and Lung Disease
JID - 9706389
RN  - 0 (Antitubercular Agents)
SB  - IM
MH  - Adolescent
MH  - Antitubercular Agents/adverse effects
MH  - Child
MH  - Cohort Studies
MH  - Humans
MH  - Qualitative Research
MH  - South Africa/epidemiology
MH  - *Tuberculosis, Multidrug-Resistant/drug therapy
EDAT- 2020/02/02 06:00
MHDA- 2021/04/28 06:00
CRDT- 2020/02/02 06:00
PHST- 2020/02/02 06:00 [entrez]
PHST- 2020/02/02 06:00 [pubmed]
PHST- 2021/04/28 06:00 [medline]
AID - 10.5588/ijtld.19.0207 [doi]
PST - ppublish
SO  - Int J Tuberc Lung Dis. 2020 Jan 1;24(1):43-47. doi: 10.5588/ijtld.19.0207.