PMID- 32006209
OWN - NLM
STAT- MEDLINE
DCOM- 20201211
LR  - 20220716
IS  - 1937-5395 (Electronic)
IS  - 1937-5387 (Print)
IS  - 1937-5387 (Linking)
VI  - 13
IP  - 5
DP  - 2020 Oct
TI  - Myoglobin for Detection of High-Risk Patients with Acute Myocarditis.
PG  - 853-863
LID - 10.1007/s12265-020-09957-8 [doi]
AB  - There is an unmet need for accurate and practical screening to detect 
      myocarditis. We sought to test the hypothesis that the extent of acute 
      myocarditis, measured by late gadolinium enhancement (LGE) on cardiac magnetic 
      resonance imaging (CMR), can be estimated based on routine blood markers. A total 
      of 44 patients were diagnosed with acute myocarditis and included in this study. 
      There was strong correlation between myoglobin and LGE (r(s) = 0.73 [95% CI 0.51; 
      0.87], p < 0.001), while correlation was weak between LGE and TnT-hs (r(s) = 0.37 
      [95% CI 0.09; 0.61], p = 0.01). Receiver operating curve (ROC) analysis 
      determined myoglobin >/= 87 mug/L as cutoff to identify myocarditis (92% 
      sensitivity, 80% specificity). The data were reproduced in an established model 
      of coxsackievirus B3 myocarditis in mice (n = 26). These data suggest that 
      myoglobin is an accurate marker of acute myocarditis. Graphical Abstract Receiver 
      operating curve analysis determined myoglobin >/= 87 mug/L as cutoff to identify 
      myocarditis and these data were reproduced in an established model of 
      coxsackievirus B3 myocarditis in mice: CMRI, cardiac magnetic resonance imaging; 
      Mb, myoglobin; LGE, late gadolinium enhancement; ROC, receiver operating curve 
      analysis.
FAU - Kottwitz, Jan
AU  - Kottwitz J
AD  - Emergency Department, University Hospital of Zurich, Zurich, Switzerland.
AD  - Department of Anesthesiology, Intensive Care, Rescue and Pain Medicine, 
      Kantonsspital St. Gallen, St. Gallen, Switzerland.
FAU - Bruno, Katelyn A
AU  - Bruno KA
AD  - Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USA.
FAU - Berg, Jan
AU  - Berg J
AD  - Department of Cardiology, University Hospital of Zurich, Zurich, Switzerland.
FAU - Salomon, Gary R
AU  - Salomon GR
AD  - Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USA.
FAU - Fairweather, DeLisa
AU  - Fairweather D
AD  - Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USA.
FAU - Elhassan, Mawahib
AU  - Elhassan M
AD  - Department of Cardiology, University Hospital of Zurich, Zurich, Switzerland.
FAU - Baltensperger, Nora
AU  - Baltensperger N
AD  - Department of Cardiology, University Hospital of Zurich, Zurich, Switzerland.
FAU - Kissel, Christine K
AU  - Kissel CK
AD  - Department of Cardiology, University Hospital of Zurich, Zurich, Switzerland.
FAU - Lovrinovic, Marina
AU  - Lovrinovic M
AD  - Department of Cardiology, University Hospital of Zurich, Zurich, Switzerland.
FAU - Baltensweiler, Andrea
AU  - Baltensweiler A
AD  - Department of Cardiology, University Hospital of Zurich, Zurich, Switzerland.
FAU - Schmied, Christian
AU  - Schmied C
AD  - Department of Cardiology, University Hospital of Zurich, Zurich, Switzerland.
FAU - Templin, Christian
AU  - Templin C
AD  - Department of Cardiology, University Hospital of Zurich, Zurich, Switzerland.
FAU - Lima, Joao A C
AU  - Lima JAC
AD  - Department of Cardiology, The Johns Hopkins University, Baltimore, MD, USA.
FAU - Landmesser, Ulf
AU  - Landmesser U
AD  - Department of Cardiology, Charite Universitatsmedizin Berlin, Campus Benjamin 
      Franklin, Hindenburgdamm 30, 12203, Berlin, Germany.
FAU - Luscher, Thomas F
AU  - Luscher TF
AD  - Center for Molecular Cardiology, University of Zurich, Zurich, Switzerland.
AD  - Royal Brompton and Harefield Hospitals and Imperial College, London, UK.
FAU - Manka, Robert
AU  - Manka R
AD  - Department of Cardiology, University Hospital of Zurich, Zurich, Switzerland.
FAU - Heidecker, Bettina
AU  - Heidecker B
AUID- ORCID: 0000-0002-3811-7920
AD  - Department of Cardiology, University Hospital of Zurich, Zurich, Switzerland. 
      bettina.heidecker@charite.de.
AD  - Department of Cardiology, Charite Universitatsmedizin Berlin, Campus Benjamin 
      Franklin, Hindenburgdamm 30, 12203, Berlin, Germany. 
      bettina.heidecker@charite.de.
LA  - eng
GR  - R21 AI145356/AI/NIAID NIH HHS/United States
GR  - R21 AI152318/AI/NIAID NIH HHS/United States
GR  - R21 AI154927/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20200131
PL  - United States
TA  - J Cardiovasc Transl Res
JT  - Journal of cardiovascular translational research
JID - 101468585
RN  - 0 (Biomarkers)
RN  - 0 (Contrast Media)
RN  - 0 (Myoglobin)
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Animals
MH  - Biomarkers/blood
MH  - Contrast Media/*administration & dosage
MH  - Coxsackievirus Infections/blood/diagnostic imaging/virology
MH  - Disease Models, Animal
MH  - Female
MH  - Humans
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Mice, Inbred BALB C
MH  - Middle Aged
MH  - Myocarditis/*blood/*diagnostic imaging/virology
MH  - Myoglobin/*blood
MH  - Predictive Value of Tests
MH  - Reproducibility of Results
MH  - Retrospective Studies
PMC - PMC7541375
OTO - NOTNLM
OT  - Biomarker
OT  - Cardiac enzymes
OT  - Late gadolinium enhancement
OT  - Magnetic resonance imaging
OT  - Myocardial inflammation
OT  - Myocarditis
OT  - Myoglobin
OT  - Troponin
COIS- The authors declare that they have no conflict of interest. This work was 
      presented in part at the meeting of the American Heart Association in Anaheim, 
      CA, November 14, 2017, and published as an abstract (Circulation.2017;136[suppl 
      I]: A15156). Further data of this work were presented in part for the Paul Dudley 
      White International Scholar Award at the meeting of the American Heart 
      Association in Chicago, IL, November 5, 2018, and published as an abstract 
      (Circulation. 2018;138[suppl I]:A12867).
EDAT- 2020/02/02 06:00
MHDA- 2020/12/15 06:00
PMCR- 2020/01/31
CRDT- 2020/02/02 06:00
PHST- 2019/11/11 00:00 [received]
PHST- 2020/01/14 00:00 [accepted]
PHST- 2020/02/02 06:00 [pubmed]
PHST- 2020/12/15 06:00 [medline]
PHST- 2020/02/02 06:00 [entrez]
PHST- 2020/01/31 00:00 [pmc-release]
AID - 10.1007/s12265-020-09957-8 [pii]
AID - 9957 [pii]
AID - 10.1007/s12265-020-09957-8 [doi]
PST - ppublish
SO  - J Cardiovasc Transl Res. 2020 Oct;13(5):853-863. doi: 10.1007/s12265-020-09957-8. 
      Epub 2020 Jan 31.