PMID- 32007300
OWN - NLM
STAT- MEDLINE
DCOM- 20210413
LR  - 20210413
IS  - 1557-9816 (Electronic)
IS  - 0955-470X (Linking)
VI  - 34
IP  - 2
DP  - 2020 Apr
TI  - Critical evaluation of a possible role of HLA epitope matching in kidney 
      transplantation.
PG  - 100533
LID - S0955-470X(20)30006-9 [pii]
LID - 10.1016/j.trre.2020.100533 [doi]
AB  - Human leukocyte antigen (HLA) matching is one of the cornerstones of organ 
      allocation in deceased-donor kidney transplantation. Increased numbers of HLA 
      allele mismatches are associated with a higher risk of immunological rejection, 
      de novo donor-specific HLA antibody development and graft failure. HLA epitopes 
      are defined as the specific portions of HLA molecules to which antibodies and 
      T-cell receptors bind with their paratopes. The same epitope can be present on 
      different HLA alleles. Therefore, HLA matching at the epitope instead of allele 
      level theoretically offers a more precise assessment of donor-recipient HLA 
      compatibility and may more effectively prevent sensitization against foreign 
      tissue. In this review, we describe the different options proposed to define 
      clinically relevant HLA epitopes and critically discuss the potential role of HLA 
      epitope matching in kidney transplantation.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Kumru Sahin, Gizem
AU  - Kumru Sahin G
AD  - Institute of Immunology, Heidelberg University Hospital, Heidelberg, Germany. 
      Electronic address: gkumru@ankara.edu.tr.
FAU - Unterrainer, Christian
AU  - Unterrainer C
AD  - Institute of Immunology, Heidelberg University Hospital, Heidelberg, Germany.
FAU - Susal, Caner
AU  - Susal C
AD  - Institute of Immunology, Heidelberg University Hospital, Heidelberg, Germany.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200117
PL  - United States
TA  - Transplant Rev (Orlando)
JT  - Transplantation reviews (Orlando, Fla.)
JID - 8804364
RN  - 0 (Epitopes)
RN  - 0 (HLA Antigens)
RN  - 0 (Isoantibodies)
RN  - 0 (Isoantigens)
SB  - IM
MH  - Epitopes/genetics/*immunology
MH  - Graft Rejection/*immunology/prevention & control
MH  - HLA Antigens/genetics/*immunology
MH  - Histocompatibility
MH  - Histocompatibility Testing/*methods/trends
MH  - Humans
MH  - Isoantibodies/*metabolism
MH  - Isoantigens/genetics/*immunology
MH  - *Kidney Transplantation
MH  - Transplantation, Homologous
OTO - NOTNLM
OT  - Donor-specific antibody
OT  - Epitope
OT  - Histocompatibility
OT  - Human leukocyte antigen
OT  - Kidney transplantation
OT  - Matching
COIS- Declaration of Competing Interest None.
EDAT- 2020/02/03 06:00
MHDA- 2021/04/14 06:00
CRDT- 2020/02/03 06:00
PHST- 2019/06/25 00:00 [received]
PHST- 2019/11/14 00:00 [revised]
PHST- 2019/11/15 00:00 [accepted]
PHST- 2020/02/03 06:00 [pubmed]
PHST- 2021/04/14 06:00 [medline]
PHST- 2020/02/03 06:00 [entrez]
AID - S0955-470X(20)30006-9 [pii]
AID - 10.1016/j.trre.2020.100533 [doi]
PST - ppublish
SO  - Transplant Rev (Orlando). 2020 Apr;34(2):100533. doi: 10.1016/j.trre.2020.100533. 
      Epub 2020 Jan 17.