PMID- 32007786
OWN - NLM
STAT- MEDLINE
DCOM- 20200903
LR  - 20221207
IS  - 1872-8421 (Electronic)
IS  - 0165-5728 (Linking)
VI  - 341
DP  - 2020 Apr 15
TI  - Analysis of plasma autoantibodies for inflammatory cytokines in patients with 
      first-episode schizophrenia among a Chinese population.
PG  - 577165
LID - S0165-5728(19)30393-5 [pii]
LID - 10.1016/j.jneuroim.2020.577165 [doi]
AB  - Neuroinflammation has been considered to be involved in the development of 
      schizophrenia. This study aimed to study circulating autoantibodies for 
      inflammatory cytokines in first-episode schizophrenia. A total of 181 patients 
      and 197 controls were recruited for detection of plasma IgG antibodies against 
      peptide antigens derived from interleukin 1alpha (IL1alpha), IL1ss, IL6, IL8 and tumour 
      necrosis factor alpha (TNFalpha). The major finding was that patients with 
      schizophrenia had significantly higher levels of anti-IL1ss IgG, anti-IL6 IgG and 
      anti-IL8 IgG, and a significantly lower level of anti-IL1alpha IgG. This study 
      suggests that inflammatory response may contribute to the development of 
      schizophrenia.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Liu, Siqi
AU  - Liu S
AD  - The Second Hospital of Jilin University, Changchun 130041, China.
FAU - Zhang, Xuan
AU  - Zhang X
AD  - The Second Hospital of Jilin University, Changchun 130041, China. Electronic 
      address: zhangxuankj@163.com.
FAU - Wang, Jiaxin
AU  - Wang J
AD  - The Second Hospital of Jilin University, Changchun 130041, China.
FAU - Yang, Hua
AU  - Yang H
AD  - Laboratory for Nursing Science & Institute of Laboratory Medicine, Guangdong 
      Medical University, Dongguan 523808, China.
FAU - Jiang, Yaling
AU  - Jiang Y
AD  - The Third People's Hospital of Jiangmen, Jiangmen 52900, China.
FAU - Qiu, Chaosen
AU  - Qiu C
AD  - The Third People's Hospital of Jiangmen, Jiangmen 52900, China.
FAU - Meng, Qingyong
AU  - Meng Q
AD  - Laboratory for Nursing Science & Institute of Laboratory Medicine, Guangdong 
      Medical University, Dongguan 523808, China. Electronic address: 
      qymeng@gdmu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200121
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Autoantibodies)
RN  - 0 (Autoantigens)
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 0 (Immunoglobulin G)
SB  - IM
MH  - Adult
MH  - Antibody Specificity
MH  - Area Under Curve
MH  - Asian People
MH  - Autoantibodies/*blood/immunology
MH  - Autoantigens/*immunology
MH  - Biomarkers
MH  - Case-Control Studies
MH  - Cytokines/*immunology
MH  - Female
MH  - Humans
MH  - Immunoglobulin G/*blood/immunology
MH  - Male
MH  - Middle Aged
MH  - ROC Curve
MH  - Schizophrenia/blood/ethnology/*immunology
MH  - Young Adult
OTO - NOTNLM
OT  - Autoantibodies
OT  - B-lymphocytes
OT  - ELISA
OT  - Inflammatory cytokines
OT  - Schizophrenia
COIS- Declaration of Competing Interest The authors declare that they have no conflict 
      of interests.
EDAT- 2020/02/03 06:00
MHDA- 2020/09/04 06:00
CRDT- 2020/02/03 06:00
PHST- 2019/08/04 00:00 [received]
PHST- 2019/12/19 00:00 [revised]
PHST- 2020/01/21 00:00 [accepted]
PHST- 2020/02/03 06:00 [pubmed]
PHST- 2020/09/04 06:00 [medline]
PHST- 2020/02/03 06:00 [entrez]
AID - S0165-5728(19)30393-5 [pii]
AID - 10.1016/j.jneuroim.2020.577165 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2020 Apr 15;341:577165. doi: 10.1016/j.jneuroim.2020.577165. Epub 
      2020 Jan 21.