PMID- 32008913 OWN - NLM STAT- MEDLINE DCOM- 20200914 LR - 20200914 IS - 1590-3729 (Electronic) IS - 0939-4753 (Linking) VI - 30 IP - 3 DP - 2020 Mar 9 TI - Effect of fatty fish or nut consumption on concentrations of persistent organic pollutants in overweight or obese men and women: A randomized controlled clinical trial. PG - 448-458 LID - S0939-4753(19)30419-3 [pii] LID - 10.1016/j.numecd.2019.11.006 [doi] AB - BACKGROUND AND AIMS: While excess energy intake and physical inactivity constitute the obvious causes of body fat accumulation, persistent organic pollutants (POPs) are novel factors that have been linked to cardiometabolic disorders. Major sources of POPs are animal fats including fatty fish. Given the putative protective effects of fish on cardiovascular disease, we explored whether high consumption of fatty fish increased serum concentrations of POPs. METHODS AND RESULTS: Men and women aged 35-70 years with body mass index between 25 and 38 kg/m(2) and at least 1 cardiometabolic component were randomized to high intakes of fatty fish (mostly farmed salmon, approximately 630 g/week; n = 45), high intakes of nuts ( approximately 200 g/week; n = 42) or a control group following their usual diet but restricting fatty fish and nuts for 6 months (n = 44). Concentrations of 15 POPs (5 organochlorinated compounds, 2 dioxin-like polychlorinated biphenyls and 8 non-dioxin-like polychlorinated biphenyls) and cardiometabolic risk factors were measured at baseline and end of the study. Results showed that changes in concentrations of individual and classes of POPs did not differ between the dietary groups and controls (p > 0.05). Among cardiometabolic risk factors HDL-cholesterol increased in the fatty fish group compared to controls (+0.10 mmol/L, CI (0.05-0.20); p = 0.005) while no changes were observed in the group consuming nuts. CONCLUSION: Fatty fish consumption for 6 months did not increase the serum concentrations of POPs in individuals with overweight or obesity and metabolic risk. While this finding appears reassuring regarding short-term intakes of farmed salmon, long term variations in POPs in adipose stores require further study. CI - Copyright (c) 2019 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved. FAU - Dusanov, Sasa AU - Dusanov S AD - Section for Preventive Cardiology, Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway. Electronic address: sasdus@ous-hf.no. FAU - Svendsen, Mette AU - Svendsen M AD - Section for Preventive Cardiology, Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway; Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo. FAU - Ruzzin, Jerome AU - Ruzzin J AD - Department of Biological Sciences, University of Bergen, Bergen, Norway. FAU - Kiviranta, Hannu AU - Kiviranta H AD - National Institute for Health and Welfare, Department of Health Security, Kuopio, Finland. FAU - Gulseth, Hanne L AU - Gulseth HL AD - Section for Preventive Cardiology, Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway; Department of Chronic Diseases and Ageing, Norwegian Instiute of Public Health, Oslo, Norway. FAU - Klemsdal, Tor O AU - Klemsdal TO AD - Section for Preventive Cardiology, Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway. FAU - Tonstad, Serena AU - Tonstad S AD - Section for Preventive Cardiology, Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway. LA - eng SI - ClinicalTrials.gov/NCT02589756 PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20191121 PL - Netherlands TA - Nutr Metab Cardiovasc Dis JT - Nutrition, metabolism, and cardiovascular diseases : NMCD JID - 9111474 RN - 0 (Environmental Pollutants) RN - 0 (Organic Chemicals) SB - IM CIN - Nutr Metab Cardiovasc Dis. 2020 May 7;30(5):849-850. PMID: 32139250 CIN - Nutr Metab Cardiovasc Dis. 2020 May 7;30(5):851-852. PMID: 32276864 MH - Adult MH - Aged MH - Animals MH - Body Mass Index MH - Consumer Product Safety MH - *Diet/adverse effects MH - Environmental Pollutants/adverse effects/*blood MH - Female MH - Fisheries MH - *Food Contamination MH - Humans MH - Male MH - Middle Aged MH - Norway MH - Nutritive Value MH - *Nuts/adverse effects MH - Obesity/*blood/diagnosis MH - Organic Chemicals/adverse effects/*blood MH - Risk Assessment MH - Risk Factors MH - *Salmon MH - *Seafood/adverse effects MH - Time Factors OTO - NOTNLM OT - Fatty fish OT - Metabolic syndrome OT - Nutrition OT - Nuts OT - Overweight/obese OT - POPs COIS- Declaration of Competing Interest The authors have no conflict of interest to declare. All authors had access to the data and have seen and approved the final submitted manuscript. EDAT- 2020/02/06 06:00 MHDA- 2020/09/15 06:00 CRDT- 2020/02/04 06:00 PHST- 2019/08/26 00:00 [received] PHST- 2019/11/12 00:00 [revised] PHST- 2019/11/14 00:00 [accepted] PHST- 2020/02/06 06:00 [pubmed] PHST- 2020/09/15 06:00 [medline] PHST- 2020/02/04 06:00 [entrez] AID - S0939-4753(19)30419-3 [pii] AID - 10.1016/j.numecd.2019.11.006 [doi] PST - ppublish SO - Nutr Metab Cardiovasc Dis. 2020 Mar 9;30(3):448-458. doi: 10.1016/j.numecd.2019.11.006. Epub 2019 Nov 21.