PMID- 32009213
OWN - NLM
STAT- MEDLINE
DCOM- 20210826
LR  - 20210826
IS  - 1432-1912 (Electronic)
IS  - 0028-1298 (Linking)
VI  - 393
IP  - 11
DP  - 2020 Nov
TI  - Long non-coding RNA OIP5-AS1 serves as an oncogene in laryngeal squamous cell 
      carcinoma by regulating miR-204-5p/ZEB1 axis.
PG  - 2177-2184
LID - 10.1007/s00210-020-01811-7 [doi]
AB  - Laryngeal squamous cell carcinoma (LSCC) is the most common type of laryngeal 
      cancer with poor prognosis. In the present study, we aimed to investigate the 
      biological role of long non-coding RNA OIP5-AS1 in LSCC. The results demonstrated 
      that the expression levels of OIP5-AS1 were significantly increased in LSCC 
      tissues and cell lines. High expression of OIP5-AS1 was closely correlated with 
      lymph node metastasis and advanced clinical stage of LSCC patients. Moreover, in 
      vitro assays showed that OIP5-AS1 overexpression promoted the proliferation, 
      migration, invasion, and epithelial-mesenchymal transition (EMT) of LSCC cells, 
      whereas OIP5-AS1 knockdown exerted suppressive effects on LSCC cells. 
      Furthermore, OIP5-AS1 was confirmed to serve as a competing endogenous RNA of 
      miR-204-5p in LSCC cells, and restoration of miR-204-5p counteracted the 
      OIP5-AS1-mediated oncogenic effects. In conclusion, our study provides promising 
      evidence that lncRNA OIP5-AS1 functions as a tumor promoter in LSCC and may be 
      used as a potential target for LSCC therapy.
FAU - Wang, Hui
AU  - Wang H
AD  - Department of Otorhinolaryngology, Heze Mudan People's Hospital, Heze City, 
      274000, Shandong Province, China.
FAU - Qian, Jiantong
AU  - Qian J
AD  - Department of Otorhinolaryngology, Juxian Traditional Chinese Medicine Hospital, 
      Rizhao City, 276500, Shandong Province, China.
FAU - Xia, Xiaojing
AU  - Xia X
AD  - Disinfection Supply Center, The People's Liberation Army No. 960 Hospital, Jinan 
      City, 250000, Shandong Province, China.
FAU - Ye, Ben
AU  - Ye B
AD  - Department of Otorhinolaryngology, Shandong Provincial Hospital, No. 324 Jingwu 
      Road, Huaiyin District, Jinan City, 250000, Shandong Province, China. 
      dr_yebensdph@163.com.
LA  - eng
PT  - Journal Article
DEP - 20200203
PL  - Germany
TA  - Naunyn Schmiedebergs Arch Pharmacol
JT  - Naunyn-Schmiedeberg's archives of pharmacology
JID - 0326264
RN  - 0 (MIRN204 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (RNA, Long Noncoding)
RN  - 0 (ZEB1 protein, human)
RN  - 0 (Zinc Finger E-box-Binding Homeobox 1)
RN  - 0 (long noncoding RNA OIP5, human)
SB  - IM
MH  - Cell Line, Tumor
MH  - Cell Movement
MH  - Cell Proliferation
MH  - Epithelial-Mesenchymal Transition
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Laryngeal Neoplasms/genetics/*metabolism/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - MicroRNAs/genetics/*metabolism
MH  - Middle Aged
MH  - Neoplasm Invasiveness
MH  - Neoplasm Staging
MH  - *Oncogenes
MH  - RNA, Long Noncoding/genetics/*metabolism
MH  - Squamous Cell Carcinoma of Head and Neck/genetics/*metabolism/secondary
MH  - Zinc Finger E-box-Binding Homeobox 1/genetics/*metabolism
OTO - NOTNLM
OT  - Epithelial-mesenchymal transition
OT  - Laryngeal squamous cell carcinoma
OT  - Long non-coding RNA OIP5-AS1
OT  - microRNA-204-5p
EDAT- 2020/02/06 06:00
MHDA- 2021/08/27 06:00
CRDT- 2020/02/04 06:00
PHST- 2019/10/09 00:00 [received]
PHST- 2020/01/04 00:00 [accepted]
PHST- 2020/02/06 06:00 [pubmed]
PHST- 2021/08/27 06:00 [medline]
PHST- 2020/02/04 06:00 [entrez]
AID - 10.1007/s00210-020-01811-7 [pii]
AID - 10.1007/s00210-020-01811-7 [doi]
PST - ppublish
SO  - Naunyn Schmiedebergs Arch Pharmacol. 2020 Nov;393(11):2177-2184. doi: 
      10.1007/s00210-020-01811-7. Epub 2020 Feb 3.